Administrative Core

行政核心

基本信息

批准号：
10699953
负责人：
Suzanne Walker
金额：
$ 13.13万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-07 至 2026-06-30
项目状态：
未结题

项目摘要

PROJECT SUMMARY – Administrative Core This Combating Antibiotic Resistant Bacteria (CARB) proposal outlines the design and function of a multidisciplinary, collaborative partnership applying new and innovative approaches to understand the mechanisms underlying bacterial envelope assembly and enable the discovery of treatments against multidrug- resistant infections. Because this is an academic effort, emphasis will be on developing the scientific knowledge that will allow discovery of new compounds and protein therapeutics for especially challenging and unexploited targets involved in cell envelope biogenesis, with membrane proteins and protein complexes a focal point in all three projects. The project team comprises an accomplished group of scientists with extensive and synergistic expertise in biochemistry, including reconstitutions of multi-enzyme pathways and large protein machines, in structural biology of membrane proteins and membrane protein complexes, in approaches for discovery of components essential for cell envelope biogenesis, in the creative use of genetic screens to dissect the regulation of pathways important in cell division and envelope biogenesis, and in development of new technologies and screening approaches for discovery of antimicrobial compounds and therapeutic proteins. Synergistic expertise in both the Gram-negative and Gram-positive cell envelopes is also well-represented among the project team members. The scientific expertise of the project team will be complemented by substantial administrative experience. The goal of the CARB Administrative Core therefore is to oversee the smooth implementation of the research plan and deployment of resources, and to foster the cohesive and well- functioning whole to achieve goals that are greater than the sum of the individual projects. This will be accomplished by achieving the following Specific Aims: 1) Provide program management, oversight, and compliance assurance, 2) Facilitate regular interactions among CARB investigators and trainees from the various labs and projects in a smooth and effective manner, and promote connectivity with other Harvard-wide initiatives; 3) Provide critical infrastructure for fiscal management of the program; 4) Provide a single point of contact and active coordination for on-going communication with NIAID, the Program Officer, and other NIAID staff and initiatives. The Administrative Core will foster the continued development of a highly functioning, well integrated, and synergistic whole to contribute to much-needed scientific advances in a challenging area of research that holds considerable promise for overcoming antibiotic resistance, while generating resources and fostering data sharing with the greater scientific community.

项目摘要 – 行政核心该对抗抗生素耐药性细菌 (CARB) 提案概述了一种抗生素耐药性细菌的设计和功能多学科的合作伙伴关系应用新的和创新的方法来理解细菌包膜组装的机制，并使得能够发现针对多种药物的治疗方法由于这是一项学术工作，因此重点将放在发展科学知识上。这将有助于发现新的化合物和蛋白质疗法，用于特别具有挑战性和未开发的领域参与细胞膜生物发生的靶标，其中膜蛋白和蛋白质复合物是所有细胞膜的焦点该项目团队由一群具有广泛协作能力的优秀科学家组成。生物化学方面的专业知识，包括多酶途径和大型蛋白质机器的重建，膜蛋白和膜蛋白复合物的结构生物学，在发现方法中细胞膜生物发生所必需的成分，创造性地利用遗传筛选来剖析调节细胞分裂和包膜生物发生以及新细胞开发中重要的途径发现抗菌化合物和治疗性蛋白质的技术和筛选方法。革兰氏阴性和革兰氏阳性细胞包膜的协同专业知识也得到了很好的体现项目团队成员的科学专业知识将得到补充。因此，CARB 行政核心的目标是监督顺利实施研究计划和资源调配，形成凝聚力和良好的凝聚力整体运作以实现大于各个项目总和的目标。通过实现以下具体目标来实现： 1) 提供计划管理、监督和合规保证，2) 促进 CARB 调查员和来自不同部门的学员之间的定期互动以平稳有效的方式开展实验室和项目，并促进与哈佛范围内其他举措的联系； 3) 为该计划的财务管理提供关键基础设施； 4) 提供单点联系和积极协调与 NIAID、项目官员和其他 NIAID 工作人员的持续沟通行政核心将促进一个高度运作、高度整合、和协同整体，为具有挑战性的研究领域急需的科学进步做出贡献在克服抗生素耐药性、同时产生资源和培育数据方面具有巨大的希望与更大的科学界分享。