Young Sexual Minority Women's Mental Health: Developmental Trajectories, Mechanisms of Risk, and Protective Factors.

年轻性少数女性的心理健康：发展轨迹、风险机制和保护因素。

基本信息

批准号：
10635506
负责人：
SARAH W WHITTON
金额：
$ 80.44万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-15 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10635506
关键词：
Address Adolescence Affect Age Anxiety Anxiety Disorders Attention Behavioral Biological Biological Markers Biological Process Black race Buffers C-reactive protein Childhood Communities Coping Skills Data Data Set Development Disparity Economics Face Family Feeling hopeless Funding Gender Gender Identity Goals Grant Heterosexuals Impairment Individual Inflammatory Interleukin-10 Interleukin-6 Intervention Knowledge Latinx Lesbian Gay Bisexual Lesbian Gay Bisexual Transgender Longitudinal Studies Longitudinal cohort study Measurement Mediating Mental Depression Mental Health Mental disorders Minority Modeling National Institute of Child Health and Human Development National Institute of Mental Health Participant Pathological anxiety Pattern Policies Process Public Health Race Reporting Research Resources Risk Risk Factors Sampling Self-Injurious Behavior Severities Sex Orientation Sexual Health Sexual and Gender Minorities Skin Social Processes Social isolation Strategic Planning Stress Suicide Symptoms Testing United States National Institutes of Health Victimization Violence Vulnerable Populations Woman cognitive process depressive symptoms design emerging adult emotion regulation evidence base experience family support gender minority group gender minority health health disparity health equity improved innovation interest men minority stress minority stressor multi-racial negative affect non-heterosexual nonbinary prevent programs prospective protective effect protective factors psychologic psychological symptom racial diversity rumination sexual minority sexual minority group sexual minority men sexual minority women social social stigma suicidal systemic inflammatory response theories therapy development young adult

项目摘要

Sexual minority women experience alarmingly high rates of mental health problems, including anxiety disorders, depression, and suicidality, which are significantly higher than those of both heterosexual women and sexual minority men. The overarching goals of this project are to address these mental health disparities and advance our ability to prevent and treat mental illness among sexual minority women by conducting an innovative, longitudinal study of mental health in young sexual minority women. Building upon the largest ever longitudinal cohort study of young sexual minority women, which includes seven waves of data collected over 3 years from 390 racially diverse participants (ages 16-20 at baseline), we will collect an additional six waves of data over 2.5 years (starting at ages 21-26) with expanded measurement of mental health, risk and protective factors, and mechanisms of effect. We have four specific aims: (1) Model trajectories of sexual minority women’s mental health, including depression, anxiety, and suicidality across late adolescence and early adulthood (16-28 years), and explore demographic differences in these patterns (e.g., by race, gender identity). (2) Grounded in minority stress theory, rigorously test unique stigma-based risk factors for mental health among sexual minority women. (3) Explore biological, psychological, and social/interpersonal mechanisms through which minority stress negatively affects sexual minority women’s mental health. Specifically, we will test whether stress-sensitive inflammatory processes (C- reactive protein, IL-6, IL-10, TNFa), maladaptive emotion regulation and cognitive processes (e.g., rumination; hopelessness), and impaired social processes (social isolation; romantic relationship functioning) mediate associations between minority stress and mental health. (4) Identify individual, community, and interpersonal protective factors that buffer sexual minority women from adverse mental health effects of minority stress. Across aims, the project focuses on identifying mutable factors that can be targeted in interventions and are relevant to today’s young sexual minority women, who are diverse in race, gender identity, and specific sexual orientation identity. Findings will be used to inform development of evidence-based, culturally sensitive interventions to prevent and treat mental illness in this vulnerable group. This proposal is responsive to NOT-MD-19-001(Notice of Special Interest in Research on the Health of SGM Populations), which encourages research describing biological and social processes affecting the health of sexual and gender minorities (SGM) that will lead to the development of interventions to enhance SGM health.

性少数女性出现心理健康问题（包括焦虑）的比例高得惊人精神障碍、抑郁症和自杀倾向，明显高于异性恋女性该项目的总体目标是解决这些心理健康差异。并通过开展一项旨在提高我们预防和治疗性少数女性精神疾病的能力基于有史以来最大规模的年轻性少数女性心理健康的创新纵向研究。对年轻性少数女性的纵向队列研究，其中包括 3 年内收集的七波数据从 390 名不同种族的参与者（基线年龄为 16-20 岁）中，我们将收集另外六波超过 2.5 年（从 21-26 岁开始）的数据，扩大了心理健康、风险和保护的衡量范围我们有四个具体目标：（1）性少数群体的模型轨迹。女性的心理健康，包括青春期后期和早期的抑郁、焦虑和自杀倾向成年期（16-28 岁），并探索这些模式的人口差异（例如，按种族、性别 (2) 以少数人压力理论为基础，严格测试独特的基于耻辱的心理风险因素 (3) 探讨性少数女性的生理、心理和社会/人际健康。少数群体压力对性少数女性心理健康产生负面影响的机制。具体来说，我们将测试压力敏感的炎症过程（C反应蛋白、IL-6、IL-10、 TNFa）、适应不良的情绪调节和认知过程（例如沉思、绝望），以及受损的社会过程（社会孤立；浪漫关系功能）调解之间的联系 (4) 识别个人、社区和人际保护因素该项目旨在缓冲性少数群体女性因少数群体压力而产生的不利心理健康影响。侧重于识别可作为干预目标并与当今年轻人相关的可变因素性少数女性，在种族、性别认同和特定性取向认同方面具有多样性。研究结果将用于为制定基于证据的、文化敏感的干预措施提供信息，以预防并治疗这一弱势群体的精神疾病。本提案响应 NOT-MD-19-001（通知）。对 SGM 人群健康研究特别感兴趣），鼓励研究描述影响性少数群体（SGM）健康的生物和社会过程将导致制定干预措施以增强 SGM 健康。