Siyakhula: Growing HIV/TB Research Knowledge for Growing Healthy Kids in Eswatini

Siyakhula：为斯威士兰的健康儿童增长艾滋病毒/结核病研究知识

• 批准号: 10871957
• 负责人: ANNA M MANDALAKAS
• 金额: $ 10万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-12 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10871957
• 关键词: Aging; Antitubercular Antibiotics; Applied Research; Carotenoids; Child; Collaborations; Cutaneous; DNA Methylation; Development; Diabetes Mellitus; Dimensions; Disease; Epigenetic Process; Foundations; Funding; HIV; HIV antiretroviral; HIV/AIDS; HIV/TB; Health; Inflammaging; Knowledge; Longevity; Malnutrition; Mass Spectrum Analysis; Measures; Medicine; Mentors; Mentorship; Methods; Morbidity - disease rate; Nutritional; Pilot Projects; Premature aging syndrome; Research; Research Personnel; Research Training; Series; Tanzania; Technology Transfer; Training; Training Programs; Tuberculosis; Universities; college; experience; lectures; mortality; novel; nutrition; premature; programs; social factors; symposium; telomere

Program Summary/Abstract The Eswatini-Baylor Children’s Foundation, University of of Eswatini (UNESWA) and Baylor College of Medicine will conduct health research training in HIV and Tuberculosis (TB) induced premature aging in conjunction with the existing D43 “Siyakhula” training program. Supplemental funds will support integration of premature aging research training within all aspects of Siyakhula including mentorship, pilot project development and implementation, and implementation of novel methods to measure and document post- infectious premature aging. The additional training will be seamlessly integrated into the existing conference series and applied research training program and introduce additional complementary capacity building activities. Despite successful antiretrovirals for HIV/AIDS and despite successful antibiotics for TB, there remains increased morbidity and mortality and 5-12 years of premature aging. This one year supplemental funding proposal will collaborate with researchers in Tanzania (Drs. Mkunde Chachage and Lucy Mrema) to share their experiences and mentor Eswatini researchers in inflammaging and the detrimental bidirectional effects on diabetes and HIV on premature aging. Dr. Fred Moonga (UNESWA) will provide lectures and mentorship on social factors leading to premature aging. From BCM, Drs. Moran and DiNardo will provide lectures and mentorship in nutrition across the lifespan and epigenetic mechanisms of premature aging, respectively. The supplement will fund five to eight of the top pilot projects to help train Eswatini researchers in HIV induced premature aging-related projects. Key projects will be chosen to focus on integrating HIV/AIDS with non- communicable diseases, to document the ill effects of premature aging. Similarly, key projects that help transfer technology to measure premature epigenetic aging (telomere qPCR, DNA methylation) or document the ill effects between malnutrition and premature aging (cutaneous carotenoid or mass-spectroscopy based nutritional methods). The projects will address the multidimensional means by which HIV/AIDS and TB induce premature aging, and train Eswatini researchers how to measure and begin to mitigate premature aging.

计划摘要/摘要 斯威士兰-贝勒儿童基金会、斯威士兰大学 (UNESWA) 和贝勒学院 医学将在艾滋病毒和结核病（TB）引起的过早衰老方面开展健康研究培训 与现有的 D43“Siyakhula”培训计划相结合，补充资金将支持整合。 Siyakhula 各个方面的早衰研究培训，包括指导、试点项目 制定和实施以及实施衡量和记录事后的新方法 传染性早衰。额外的培训将无缝整合到现有的会议中。 系列和应用研究培训计划，并引入额外的补充能力建设 活动。 尽管抗逆转录病毒治疗艾滋病毒/艾滋病取得了成功，尽管抗生素治疗结核病也取得了成功，但仍然存在 发病率和死亡率增加以及 5-12 岁的过早衰老 这一年的补充资金。 该提案将与坦桑尼亚的研究人员（Mkunde Chachage 博士和 Lucy Mrema 博士）合作，分享他们的成果 经验并指导斯威士兰研究人员在炎症和痛苦双向影响方面 Fred Moonga 博士（UNESWA）将提供有关糖尿病和艾滋病毒与过早衰老的讲座和指导。 导致过早衰老的社会因素，Moran 和 DiNardo 博士将提供讲座和 分别对整个生命周期的营养和过早衰老的表观遗传机制进行指导。 该补助金将资助五到八个顶级试点项目，以帮助培训斯威士兰研究人员进行艾滋病毒诱导治疗 将选择与过早老龄化相关的重点项目，重点关注艾滋病毒/艾滋病与非艾滋病防治的结合。 传染病，记录过早衰老的不良影响。同样有帮助的关键项目 转移技术来测量表观遗传过早衰老（端粒 qPCR、DNA 甲基化）或文档 营养不良和过早衰老之间的不良影响（皮肤类胡萝卜素或基于质谱的 这些项目将探讨诱发艾滋病毒/艾滋病和结核病的多方面方式。 过早衰老，并培训斯威士兰研究人员如何测量并开始减轻过早衰老。