Siyakhula: Growing HIV/TB Research Knowledge for Growing Healthy Kids in Eswatini

Siyakhula：为斯威士兰的健康儿童增长艾滋病毒/结核病研究知识

• 批准号: 10241841
• 负责人: ANNA M MANDALAKAS
• 金额: $ 30.28万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-12 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10241841
• 关键词: AIDS/HIV problem; Adolescent; Affect; Applied Research; Area; Back; Behavioral Sciences; Bioinformatics; Biometry; Child; Child Health; Childhood; Clinical Research; Collaborations; Communities; Country; Doctor of Philosophy; Educational process of instructing; Enrollment; Ensure; Epidemic; Epidemiology; Funding; Future; Goals; HIV; HIV/TB; Health; Health Professional; Health Promotion; Health Promotion Sciences; Health system; Infant; Institution; Investigation; Knowledge; Lead; Master of Public Health; Medicine; Mentors; Pediatrics; Policies; Population; Public Health; Public Health Schools; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Priority; Scientist; Texas; Training; Training Programs; Translational Research; Tuberculosis; United States National Institutes of Health; Universities; base; behavioral health; cohort; college; comorbidity; environmental enrichment for laboratory animals; international center; mortality; multidisciplinary; next generation; novel; pediatric human immunodeficiency virus; programs; skills; success

Program Summary/Abstract In collaboration with the University of Eswatini and the Eswatini Ministry of Health (including national HIV and TB programs), Baylor College of Medicine (BCM) will conduct training in HIV/AIDS research methods with a focus on pediatrics and Tuberculosis (TB) co-morbidity. Other key partners include The University of Texas School of Public Health (UTHealth SPH) who will support and mentor long-term trainees during Public Health Masters and Doctoral level studies. Our collaborative HIV/TB training program will train i) three doctoral candidates to become Independent Investigators in clinical and translational research focusing on HIV/TB in pediatric (infants, children, and adolescents) populations, and ii) two in-country cohorts of public health trainees to become Associate Investigators in child health research. The training capitalizes on a novel Eswatini-US dual mentoring strategy to ensure retention, success, and relevance of research conducted by US-based long-term Siyakhula Scholars. Long-term Siyakhula Scholars will enroll in UTHealth SPH to earn a PhD or DrPH and conduct thesis activities in Eswatini engaging in-country Siyakhula Scholars and mentors. We will employ a "teach-back" approach in which the long-term trainees participate in Eswatini-based training forums to develop teaching skills and strengthen partnerships with in-country scholars. Our goal is to strengthen clinical research capacity in Eswatini while simultaneously producing high-quality researchers who will successfully transition to independence, obtain independent funding and lead national efforts to end the HIV/TB epidemic, now the leading infectious causes of mortality globally. We have developed a training plan that has adapted to today's HIV research priorities appropriately focused on TB specific comorbidity while being aligned with the Eswatini National Research Strategy and priorities of the US NIH and Fogarty International Center. Building on our past successes, we will train the next generation of HIV scientists in four essential programmatic areas including epidemiology, biostatistics and bio-informatics, behavioral science and health promotion, and health systems management and policy. We will develop capacity in these cornerstones of multidisciplinary clinical and translational research by accomplishing the following specific aims: 1) Capitalize on existing pediatric HIV expertise to enhance investigation of HIV/TB co-affected children and provide long-term training to produce Independent Emaswati Investigators in the most recent advances in the fields of epidemiology, biostatistics & bio-informatics, behavioral science & health promotion, and health systems management & policy; 2) Provide intensive in-country training in Child Health Applied Research Methods to well-qualified Siyakhula Scholars from partner institutions in Eswatini; 3) Support local research infrastructure and the existing research community while enriching the environment and capacity to support educational research opportunities for future health professionals.

程序摘要/摘要 与埃斯瓦蒂尼大学和埃斯瓦蒂尼卫生部合作（包括国家艾滋病毒和 结核病计划），贝勒医学院（BCM）将在艾滋病毒/艾滋病研究方法中进行培训 专注于小儿和结核病（TB）合并症。其他主要合作伙伴包括德克萨斯大学 公共卫生学院（UTHealth SPH），将在公共卫生期间支持和指导长期学员 硕士和博士研究。我们的合作艾滋病毒/结核病培训计划将培训i）三个博士 候选人成为关注HIV/TB的临床和转化研究的独立研究者 小儿（婴儿，儿童和青少年）人口，ii）两名国内群体 成为儿童健康研究的副研究人员。培训资源是在新颖的Eswatini-us双重上 指导策略，以确保基于美国长期进行的研究的保留，成功和相关性 Siyakhula学者。长期的西亚克胡拉学者将招收Uthealth SPH以获得博士学位或DRPH，并且 在埃斯瓦蒂尼（Eswatini）进行论文活动，参与国内西亚库拉学者和导师。我们将采用一个 长期学员参加基于Eswatini的培训论坛以发展的“教导”方法 教学技能并加强与国内学者的合作伙伴关系。我们的目标是加强临床研究 埃斯瓦蒂尼的能力同时生产高质量的研究人员，他们将成功过渡到 独立，获得独立资金并领导国家努力结束艾滋病毒/结核病流行，现在是领先的 全球死亡率的传染性原因。我们制定了一个适应当今艾滋病毒的培训计划 研究优先级适当地集中在特定于结核病的同时，同时与Eswatini保持一致 美国国民党和福加蒂国际中心的国家研究策略和优先事项。建立我们的过去 成功，我们将在四个基本程序化领域的下一代艾滋病毒科学家培训 流行病学，生物统计学和生物信息学，行为科学与健康促进以及卫生系统 管理和政策。我们将在这些多学科临床基础上发展能力 通过完成以下特定目的来转化研究：1）利用现有的儿科艾滋病毒 专业知识以增强对艾滋病毒/结核病共同影响儿童的调查，并提供长期培训以生产 独立的Emaswati研究者在流行病学，生物统计学和 生物信息学，行为科学与健康促进以及卫生系统管理与政策； 2）提供 对儿童健康应用研究方法进行的强化国内培训，从合格的Siyakhula学者那里 Eswatini的合作伙伴机构； 3）支持本地研究基础设施和现有研究社区 同时丰富了支持未来健康的教育研究机会的环境和能力 专业人士。