Developing research leaders at the intersection of malnutrition and tuberculosis in Tanzania

培养坦桑尼亚营养不良和结核病交叉领域的研究领导者

• 批准号: 10875013
• 负责人: Scott K Heysell
• 金额: $ 15万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10875013
• 关键词: Africa; Career Choice; Collaborations; Communicable Diseases; Communication; Compensation; Competence; Counseling; Country; Disease; Economics; Equity; Faculty; Goals; Grant; Health Sciences; Immunosuppression; Infectious Diseases Research; Internships; Lead; Leadership; Malnutrition; Maps; Mentorship; Methods; Needs Assessment; Postdoctoral Fellow; Recommendation; Reporting; Research; Research Personnel; Research Training; Schools; Scientist; Students; Tanzania; Training; Training Programs; Travel; Tuberculosis; Underrepresented Minority; Underrepresented Students; United Nations; Universities; Virginia; Wages; World Health Organization; Writing; career; design; experience; global health; hands on research; interest; programs; recruit; scale up; skills; social; tuberculosis treatment; undergraduate student; university student; virtual

ABSTRACT/ SUMMARY In non-pandemic periods, tuberculosis (TB) is the leading killer worldwide from a curable infectious disease. Malnutrition related immunosuppression is the most important driver of conversion from latent Mycobacterium tuberculosis infection to active TB disease. Yet TB disease itself worsens malnutrition, while the physical, social and economic consequences of TB treatment all predispose to sequelae of persistent malnutrition. The United Nations and World Health Organization’s End TB Strategy recommends scaling-up of research training of scientists in TB endemic settings skilled in the End TB research goals. Given that researchers and educators from the University of Virginia (UVA) and Tanzania are currently working in collaborative research in multiple domains of malnutrition and TB, we performed a countrywide needs assessment to map the competencies of successful research leaders identified in the Path to Research Leadership Report in Africa 2020. We then designed the current Global Infectious Diseases Research Training Program (GIDRTP- D43 TW012247, now grant year 2), to train 6 postdoctoral Tanzanian scientists in research leadership excellence at the intersection of malnutrition and TB, and within the components of research team management, communication, grant writing, professionalism and career trajectory. Tanzanian postdoctoral scientists receive 3 years of salary support, mentorship with UVA and Tanzanian faculty at strategic institutes, and lead a team of staff scientists, Tanzanian Master’s students, and undergraduate students from UVA (2 per postdoctoral scientist led team) utilizing the eGlobal program of virtual/online engagement. While interest is high for undergraduates across varied schools at UVA for participation in the GIDRTP and eGlobal program, the majority have prior global travel experience and do not identify as underrepresented in health sciences. Furthermore, the current eGlobal program does not provide a summative travel experience to Tanzania. This supplement will 1) recruit and retain 8 new undergraduate students that are underrepresented in health sciences for a year’s longitudinal internship in global research engagement and a summative hands- on research experience in Tanzania with their Tanzanian postdoctoral scientist-led team; 2) do so through equitable compensation of stipend during the internship; 3) provide UVA faculty led training for undergraduates in global health career tracks, methods of cross-cultural research collaboration, and pre/post travel counseling; and 4) advance the research team leadership skills of the Tanzanian postdoctoral scientists following the integration of undergraduates with diverse lived backgrounds. We expect this adaptation of the eGlobal program for underrepresented minorities in global health sciences can be scaled to other training programs and scientific foci.

摘要/摘要 在非大流行时期，结核病（TB）是全世界的主要杀手，来自健康的传染病。 与营养不良有关的免疫抑制是潜在的分枝杆菌转化的最重要驱动因素 结核病感染活性结核病。然而，结核病本身会恶化营养不良，而身体则恶化 结核病治疗的社会和经济后果均易于持续营养不良的后遗症。 联合国和世界卫生组织的结束结核病战略建议扩大研究培训 结核病内粒环境中的科学家最终熟练于结核病研究目标。鉴于研究人员和 弗吉尼亚大学（UVA）和坦桑尼亚的教育工作者目前正在从事合作研究 营养不良和结核病的多个领域，我们进行了全国需求评估，以绘制 在非洲研究领导力报告中确定的成功研究领导者的能力 2020年。然后，我们设计了当前的全球传染病研究培训计划（GIDRTP-D43 TW012247，现已授予2年），培训6个坦桑尼亚博士后科学家在研究领导力卓越的研究领导 营养不良与结核病的交集，以及研究团队管理的组成部分， 沟通，赠款写作，专业和职业轨迹。坦桑尼亚博士后科学家接受 战略机构的UVA和坦桑尼亚教职员工的薪水支持3年，领导团队 来自UVA的员工科学家，坦桑尼亚硕士的学生和本科生（每人2个 科学家LED团队）使用虚拟/在线参与的Eglobal计划。 虽然UVA各种学校的本科生的兴趣很高，以参加GIDRTP和 Eglobal计划，大多数具有以前的全球旅行经验，并且没有确定为不足的人数 健康科学。此外，当前的Eglobal计划没有为 坦桑尼亚。该补充剂将为1）招募和保留8位新的本科生的人数不足 一年在全球研究参与方面的纵向实习的卫生科学领域， 关于坦桑尼亚的研究经验以及坦桑尼亚的博士后科学家团队； 2）这样做 实习期间的公平压力赔偿； 3）为大学生提供UVA教师LED培训 在全球健康职业轨道上，跨文化研究合作的方法以及旅行前/旅行咨询； 4）提高坦桑尼亚博士后科学家的研究团队领导技能 将大学生与潜水员的现场背景的整合。我们期望Eglobal的这种改编 全球健康科学中代表性不足的少数民族计划可以扩展到其他培训计划 和科学焦点。

项目成果

Implementing Innovative Approaches to Improve Health Care Delivery Systems for Integrating Communicable and Non-Communicable Diseases Using Tuberculosis and Diabetes as a Model in Tanzania.

• DOI: 10.3390/ijerph20176670
• 发表时间: 2023-08-29
• 期刊: International journal of environmental research and public health
• 作者: Mpagama SG;Byashalira KC;Chamba NG;Heysell SK;Alimohamed MZ;Shayo PJ;Kalolo A;Chongolo AM;Gitige CG;Mmbaga BT;Ntinginya NE;Alffenaar JC;Bygbjerg IC;Lillebaek T;Christensen DL;Ramaiya KL
• 通讯作者: Ramaiya KL

Protocol for a feasibility randomized controlled trial to evaluate the efficacy, safety and tolerability of N-acetylcysteine in reducing adverse drug reactions among adults treated for multidrug-resistant tuberculosis in Tanzania.

• DOI: 10.1186/s40814-023-01281-7
• 发表时间: 2023-04-01
• 期刊: PILOT AND FEASIBILITY STUDIES
• 影响因子: 1.7
• 作者: Mpagama, Stellah G. G.;Mvungi, Happiness C. C.;Mbelele, Peter M. M.;Semvua, Hadija H. H.;Liyoyo, Alphonce A. A.;de Guex, Kristen Petros;Sloan, Derek;Kibiki, Gibson S. S.;Boeree, Martin;Phillips, Patrick P. J.;Heysell, Scott K. K.
• 通讯作者: Heysell, Scott K. K.

Whole genome sequencing-based drug resistance predictions of multidrug-resistant Mycobacterium tuberculosis isolates from Tanzania.

• DOI: 10.1093/jacamr/dlac042
• 发表时间: 2022-04
• 期刊: JAC-antimicrobial resistance
• 影响因子: 3.4