MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS - TOPMED

动脉粥样硬化的多种族研究 - TOPMED

• 批准号: 10974007
• 负责人: ROBYN MCCLELLAND
• 金额: $ 57.14万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-15 至 2024-12-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10974007
• 关键词: MULTI; ETHNIC; STUDY; ATHEROSCLEROSIS; TOPMED

NHLBI's Trans-Omics for Precision Medicine (TOPMed) program started in 2014 as the flagship program supporting the development of precision medicine for heart, lung, blood diseases and sleep disorders. The main goal is to generate a large volume of genomics data that have sufficient statistical power for scientific discovery. The data are generated and processed first in TOPMed before being uploaded to external databases, database of Genotypes and Phenotypes (dbGaP) and BioData Catalyst (BDC) for researchers to access. In 2016, under TOPMed program, NHLBI funded nine (9) Centralized Omics Resource (CORE) centers that have generated approximately 200,000 whole genome sequencing and multi-omics data. As TOPMed enters its next phase TOPMed2.0 focusing on functional genomics and disease mechanism, the CORE needs to be upgraded to CORE 2.0 generating more functional genomics data, including omics data at single-cell resolution. CORE 2.0 needs to generate a large volume of functional genomics data and is in need of contractors that can provide a high capability of generating omics data.

NHLBI的精密医学跨词（TopMed）计划始于2014年，是一项旗舰计划，支持开发针对心脏，肺，血液疾病和睡眠障碍的精密医学。主要目标是生成大量具有科学发现统计能力的基因组学数据。在将数据库，基因型和表型数据库（DBGAP）和Biodata Catalyst（BDC）上传到外部数据库之前，首先生成和处理数据，以供研究人员访问。在2016年，NHLBI资助了9（9）个集中的OMICS（CORE）中心，这些中心已经生成了大约200,000个整个基因组测序和多媒体数据。当Topmed进入其下一个阶段TopMed2.0，重点是功能基因组学和疾病机制时，需要将核心升级到Core 2.0生成更多功能基因组学数据，包括单细胞分辨率的OMICS数据。 Core 2.0需要生成大量功能基因组学数据，并且需要承包商，这些承包商可以提供高能力生成OMICS数据。