IGF::OT::IGF - MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)III- COORDINATING CENTER

IGF::OT::IGF - 动脉粥样硬化多种族研究 (MESA)III- 协调中心

• 批准号: 9173495
• 负责人: ROBYN MCCLELLAND
• 金额: $ 501.17万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2016-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9173495
• 关键词: Abdomen; Ancillary Study; Ankle; Area; Atherosclerosis; Behavioral; Biological; Cardiac; Cardiovascular Diseases; Characteristics; Clinical; Contracts; Coronary Arteriosclerosis; Data; Data Set; Diabetic Retinopathy; Disease; Ethnic Origin; Event; Family; Funding; Fundus photography; Genetic; Health Status; Laboratories; Macular degeneration; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mentors; Microvascular Dysfunction; Myocardial; Nutritional; Participant; Pathology; Pharmaceutical Preparations; Phenotype; Photography; Policies; Population Heterogeneity; Process; Recruitment Activity; Research; Research Design; Research Personnel; Retinal; Risk Marker; Sampling; Severities; Signs and Symptoms; Systemic disease; Time; Training; Ultrasonography; United States National Institutes of Health; Ventricular Function; Visit; Visual; Visual Acuity; Visual impairment; Woman; Work; X-Ray Computed Tomography; aged; base; brachial artery; cohort; data sharing; design; digital; follow-up; imaging modality; indexing; interest; member; men; population based; psychologic; racial/ethnic difference; radial artery; sex; socioeconomics

The Multi-Ethnic Study of Atherosclerosis (MESA), a study of the correlates, predictors and progression of subclinical cardiovascular disease (CVD) (disease detected non-invasively before it has produced clinical signs and symptoms) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. Six thousand eight hundred and fourteen (6,814) participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tomometry, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, nutritional and environmental characteristics; and genetic factors. Selected components were repeated over three subsequent examinations through 2007. The cohort has been followed for clinical events since baseline to ascertain and characterize new clinical events and other changes in health status, including changes in medications. The four scientific objectives for the period 2008 through 2015 are (1) identify factors related to progression of subclinical to clinical CVD; (2) identify predictors of decline in ventricular function; (3) further understanding of the basis for racial/ethnic difference in CVD; and (4) provide a platform for in-depth ancillary studies of CVD and other areas. All surviving and willing members of the MESA cohort will be followed up during the time period and included in an fifth examination during 2010-2012. The study will support in-depth ancillary studies that are funded outside of the current contracts. These studies will be operationally integrated into the main study, and the data will be shared across both types of studies, per current MESA and NIH data-sharing policies. The study's data will be provided to interested investigators through a defined process that encourages maximum data utilization but that protects participant confidentially. The study will also serve as a training ground for junior investigators, who will work with senior investigators and be provided with access to the MESA data set and guidance on conducting research. The MESA-EYE component (refraction and fundus photography) was integrated into the second MESA visit in which 6235 people participated between September 2002 and December 2003. The aims of the ocular component were to document the presence and severity of retinal microvascular changes (as interpreted from digital retinal photos) indicative of macular degeneration and diabetic retinopathy, as well as to describe their interrelationships with cross-sectional and longitudinal measures of microvascular and macrovascular systemic disease as defined clinically, by imaging modality, or by analysis of biological laboratory measures. The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, determine the degree to which visual impairment could be reduced with better refractive correction, and correlate visual findings with retinal pathology. Analyses of various ocular phenotypes, including retinal microvascular disease in MESA Family's ancillary study.

动脉粥样硬化的多种族研究（MESA）是对亚临床心血管疾病的相关性，预测因素和进展（CVD）（CVD）（在产生临床体征和症状的临床体征和症状）之前，在其基于45--84个均具有45-84个均具有临床CVD碱基的男子和女性样本中的临床样本中，疾病在产生临床和女性中的临床表征和症状）中进行了无创。在2000年至2002年期间，从六个现场中心招募了六千八百（6,814）参与者，并使用计算机断层扫描，心脏MRI，颈动脉超声，流动介导的腕足动脉膨胀，侧面径向和伸出的距离射量和远离距离的距离，并检查了亚临床冠状动脉粥样硬化的证据。主动脉CT，颈动脉MRI，心脏心肌功能测量的心脏MRI标记；建立和推定的实验室风险标志；社会经济，心理，行为，营养和环境特征；和遗传因素。在2007年之前的三场考试中，重复了选定的组件。自基准以来，临床事件已遵循，以确定和表征新的临床事件和其他健康状况变化，包括药物的变化。 2008年至2015年期间的四个科学目标是（1）确定与临床CVD的进展有关的因素； （2）确定心室功能下降的预测因素； （3）进一步了解CVD种族/种族差异的基础； （4）为CVD和其他领域的深入辅助研究提供了一个平台。所有幸存下来且愿意的成员将在此期间进行随访，并在2010年至2012年的第五次考试中进行。该研究将支持在当前合同之外资助的深入辅助研究。这些研究将在主要研究中进行操作，并根据当前的台面和NIH数据共享策略在两种类型的研究中共享数据。该研究的数据将通过定义的流程提供给感兴趣的研究人员，该过程鼓励最大的数据利用，但可以秘密保护参与者。这项研究还将成为初级调查人员的培训理由，后者将与高级研究人员合作，并获得对MESA数据集和进行研究指南的访问。 Mesa-eye组件（折射和眼底摄影）被整合到第二次MESA访问中，在2002年9月至2003年12月之间，有6235人参与了6235人参加。眼部成分的目的是记录视网膜微血管变化的存在和严重性（如数字视网膜照片解释）与糖尿病性变性和糖尿病性的相互介绍，以及及糖尿病性的视网膜症状，并及其及其及以下各种视网膜变化，并及时构成了以及及以下造型和疾病的视网膜。微血管和大血管全身性疾病的纵向测量如临床定义，成像方式或通过分析生物实验室措施。视力/客观折射成分旨在使我们能够通过性别和种族来估计视觉障碍，确定可以通过更好的屈光度校正来减少视觉障碍的程度，并将视觉发现与视网膜病理相关。对各种眼表型的分析，包括梅萨家族辅助研究中的视网膜微血管疾病。