IGF::OT::IGF MESA - TOPMED - 08/04/2016 - 12/31/2016

IGF::OT::IGF MESA - TOPMED - 08/04/2016 - 12/31/2016

• 批准号: 9365866
• 负责人: ROBYN MCCLELLAND
• 金额: $ 39.06万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9365866
• 关键词: Atherosclerosis; Behavioral; Biological; Blood; Clinical; Clinical Data; Communities; Contracts; Coupling; DNA Methylation; Data; Disease; Ensure; Funding; Genetic Transcription; Genome; Goals; Health; Heart; Image; Individual; Institutes; Lung; Medicine; Methylation; Molecular; Molecular Profiling; National Heart, Lung, and Blood Institute; Outcome; Participant; Pilot Projects; Population Heterogeneity; Precision Medicine Initiative; Proteomics; Research; Sleep Disorders; Specimen; System; Trans-Omics for Precision Medicine; clinical phenotype; epigenomics; genome sequencing; metabolomics; precision medicine; programs; repository; whole genome

The NHLBI Trans-Omics for Precision Medicine (TOPMed) program will support the Institute’s larger precision medicine initiative by collecting and coupling whole-genome sequencing (WGS) and other -omics data (e.g., DNA methylation signature, RNA expression profiles, metabolite profiles) with molecular, behavioral, imaging, environmental, and clinical data from studies focused on heart, lung, blood and sleep (HLBS) disorders. The TOPMed program aims to: •Collect and assemble -omics (RNASeq, methylation, metabolomics, epigenomics, and proteomics) data with WGS and clinical outcomes data across diverse populations including those traditionally underrepresented in research. •Build a data commons repository that the scientific community can use for future research and to enable precision medicine. •Stimulate systems medicine approaches that help organize data to ensure they are accessible and interpretable for health disease research. •Promote discoveries about the fundamental mechanisms that underlie HLBS disorders. Establishing the WGS project was one of the first steps for the TOPMed program. The project’s goal is to collect WGS data for individuals who have well-defined clinical phenotypes and outcomes from earlier NHLBI-funded studies. Initially, the WGS project planned to sequence 20,000 genomes. The NHLBI has expanded the WGS project and it now will sequence about 62,000 individual genomes.

NHLBI精确医学（TOPMED）计划将通过收集和耦合全基因组测序（WGS）和其他 - 词素数据（例如DNA甲基化签名，RNA，RNA表达概况，代谢物，临床，临床，Imagral，Imageal，Image，Image，Imagnical，Imagnical，Imagnical，Imagnical，Imagnical copit，toper，wgs）和其他研究来支持该研究所的较大精确医学计划。 （HLB）疾病。 最佳计划的目的是： •收集和组装 - 组（RNASEQ，甲基化，代谢组学，表观基因组学和蛋白质组学）数据具有WGS和临床结果数据的数据，包括研究中传统上代表性不足的人群。 •建立一个数据共享存储库，科学界可以将其用于未来的研究并启用精确医学。 •刺激系统的医学方法，以帮助组织数据，以确保它们可用于健康疾病研究。 •促进有关HLBS疾病基础的基本机制的发现。 建立WGS项目是顶级程序的第一步之一。该项目的目标是为具有明确定义的临床表型和早期NHLBI资助的研究结果的个体收集WGS数据。最初，WGS项目计划对20,000个基因组进行序列。 NHLBI扩大了WGS项目，现在将对约62,000个单个基因组进行测序。