MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) FIELD CENTER (FC) - TASK AREA B EXAM 7

多民族动脉粥样硬化研究 (MESA) 现场中心 (FC) - 任务领域 B 考试 7

基本信息

批准号：
10470555
负责人：
WENDY POST
金额：
$ 55.68万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-19 至 2023-11-21
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10470555
关键词：
Abdomen Ancillary Study Ankle Anthropometry Area Behavioral Blood Pressure Cardiac Cardiovascular Diseases Certification Characteristics Clinical Collaborations Collection Consent Contracts Coronary Arteriosclerosis Data Disease Event Functional disorder Funding Glucose Goals Health Health behavior Laboratories Magnetic Resonance Imaging Manuals Measurement Measures Mediating Medical History Multi-Ethnic Study of Atherosclerosis Myocardial National Heart, Lung, and Blood Institute Participant Performance Pharmaceutical Preparations Photography Policies Population Heterogeneity Preparation Process Protocols documentation Questionnaires Research Personnel Retina Risk Factors Risk Marker Sampling Schedule Sleep Smoking History Subgroup Testing Training Ultrasonography United States National Institutes of Health Urine Venous blood sampling Woman X-Ray Computed Tomography aged biobank brachial artery cardiovascular disorder risk cohort demographics genetic variant healthy aging indexing interest lipid metabolism member men operation platform-independent population based predict clinical outcome protocol development psychologic radial artery recruit response socioeconomics tonometry

项目摘要

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six field centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. This proposal is written in response to the NHLBI RFP (No. 75N92020D00003, Multi-Ethnic Study of Atherosclerosis (MESA) Exam 7- Task Area B) that seeks to enable a limited reexamination by the MESA field centers of MESA participants. Task Area B will involve protocol development and finalization, exam preparation activities, a limited re-examination of all surviving and willing MESA participants from the field center, and close-out activities for Exam 7. The recruitment goal for Exam 7 is approximately 3,000 participants across all field centers. The performance of Exam 7 will allow continued scientific collaborations. which will contribute to the following MESA IV scientific objectives: 1) enhance statistical power to perform analyses of predictors of clinical outcomes, particularly in informative subgroups; 2) study the progression of subclinical to clinical CVD; and 3) identify new risk factors or interactions among factors that inform disease pathophysiology. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.

动脉粥样硬化多种族研究 (MESA) 是一项针对相关因素、预测因素和风险因素的研究不同人群男性样本中亚临床心血管疾病 (CVD) 的进展以及在初始资助期间没有临床心血管疾病证据的 45-84 岁女性。 MESA 期间，2000 年至 2002 年期间从六个外地中心招募了 6,814 名参与者使用计算机断层扫描、心脏检查检查亚临床冠状动脉粥样硬化的证据 MRI、颈动脉超声、血流介导的肱动脉扩张、桡动脉张力测量、踝肱指数测量和视网膜摄影等许多其他变量，包括腹主动脉。用于测量局部心肌功能的 CT、颈动脉 MRI、心脏 MRI 标记；假定的实验室风险标记；特征；并在 MESA 队列的子集中评估遗传变异。选定的组件在随后的五次检查中重复进行，涵盖约 16 年，自基线以来一直对队列进行临床心血管事件跟踪考试。本提案是为了响应 NHLBI RFP（编号 75N92020D00003，多民族研究动脉粥样硬化 (MESA) 考试 7- 任务领域 B) 旨在使患者能够进行有限的复查 MESA 参与者的 MESA 现场中心将涉及协议开发和实施。最终确定、考试准备活动、对所有幸存且愿意的 MESA 进行有限的重新审查现场中心的参与者以及考试 7 的结束活动。考试 7 的招募目标所有现场中心约有 3,000 名参与者，考试 7 的表现将允许。持续的科学合作将有助于实现以下 MESA IV 科学目标： 1）增强统计能力以对临床结果的预测因素进行分析，特别是在信息亚组；2) 研究亚临床到临床 CVD 的进展；3) 识别新风险；影响疾病病理生理学的因素或因素之间的相互作用。该研究将继续支持 NHLBI 之外资助的深入辅助研究这些研究将在操作上整合到主要研究中，并且数据将被共享。根据当前的 MESA 和 NIH 数据共享政策，涵盖整个“MESA 套件”研究。研究数据将通过明确的流程提供给感兴趣的研究人员，该流程鼓励最大限度地利用数据，同时保护参与者的机密性。