TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.

任务区 A - MESA 核心运营，现场中心。

基本信息

批准号：
10788258
负责人：
WENDY POST
金额：
$ 60.43万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-12-19 至 2023-12-18
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10788258
关键词：
Address African American Age Aging Air Pollution Ancillary Study Ankle Aorta Area Atherosclerosis Behavioral Biological Brain Cardiovascular Diseases Cause of Death Characteristics Chinese Clinical Collaborations Collection Communities Contracts Coronary Arteriosclerosis Correlation Studies Data Diabetes Mellitus Disease Disease Marker Disease Outcome Disease Progression Dyslipidemias Ethnic Origin Event Extramural Activities Fostering Functional disorder Funding Genetic Goals Heart Heart failure Hispanic Hypertension Incidence Investigation Kidney Laboratories Lung Magnetic Resonance Imaging Measurement Measures Mediating Multi-Ethnic Study of Atherosclerosis Myocardial National Heart, Lung, and Blood Institute Neighborhoods Obesity Organ Paper Participant Persons Photography Policies Population Population Heterogeneity Prevalence Process Publishing Race Research Personnel Retina Risk Factors Risk Marker Sampling Smoking Socioeconomic Factors Subgroup United States United States National Institutes of Health Vascular Diseases Woman Writing X-Ray Computed Tomography abdominal aorta aged brachial artery cardiac magnetic resonance imaging cardiovascular disorder risk clinical examination cohort disease disparity follow-up genetic variant heart function improved indexing insight interest men mortality operation population based predict clinical outcome psychologic radial artery recruit response sex socioeconomics tonometry trend ultrasound vascular bed

项目摘要

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. This proposal is written in response to the NHLBI RFP (No. 75N92018R0078, Multi-Ethnic Study of Atherosclerosis – Field Center) that seeks to continue the follow-up and examination of the MESA participants in an effort to address the following scientific objectives: 1) enhance statistical power to perform analyses of predictors of clinical outcomes, particularly in informative subgroups; 2) study the progression of subclinical to clinical CVD; and 3) identify new risk factors or interactions among factors that inform disease pathophysiology. In addition, the following operational goals will be addressed: 1) continue cohort follow-up and information collection to document clinical events; 2) continue to foster scientific collaborations; and 3) conduct a limited clinical examination of the MESA participants as a platform for ancillary study examination components. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality. 3

动脉粥样硬化多种族研究 (MESA) 是一项针对相关因素、预测因素和风险因素的研究不同人群男性样本中亚临床心血管疾病 (CVD) 的进展以及在初始资助期间没有临床心血管疾病证据的 45-84 岁女性。 MESA 期间，2000 年至 2002 年期间从六个现场中心招募了 6,814 名参与者使用计算机断层扫描、心脏检查检查亚临床冠状动脉粥样硬化的证据 MRI、颈动脉超声、血流介导的肱动脉扩张、桡动脉张力测量、踝肱指数测量和视网膜摄影等许多其他变量，包括腹主动脉。用于测量局部心肌功能的 CT、颈动脉 MRI、心脏 MRI 标记；假定的实验室风险标记；特征；并在 MESA 队列的子集中评估遗传变异。选定的组件在随后的五次检查中重复进行，涵盖约 16 年，自基线以来一直对队列进行临床心血管事件跟踪考试。本提案是为了响应 NHLBI RFP（编号 75N92018R0078，多民族研究动脉粥样硬化 – 现场中心）寻求继续对 MESA 进行跟踪和检查参与者努力实现以下科学目标：1）增强统计能力对临床结果的预测因素进行分析，特别是在信息丰富的亚组中；2) 研究 3) 识别新的风险因素或因素之间的相互作用此外，还将解决以下业务目标：1）继续队列随访和信息收集以记录临床事件；2) 继续促进科学合作；3) 对 MESA 参与者进行有限的临床检查辅助学习考试组件的平台。该研究将继续支持 NHLBI 之外资助的深入辅助研究这些研究将在操作上整合到主要研究中，并且数据将被共享。根据当前的 MESA 和 NIH 数据共享政策，涵盖整个“MESA 套件”研究。研究数据将通过明确的流程提供给感兴趣的研究人员，该流程鼓励最大限度地利用数据，同时保护参与者的机密性。 3