Animal Refinement for Laboratory Rodents

实验室啮齿动物的动物精炼

• 批准号: 10928602
• 负责人: Terry Blankenship-Paris
• 金额: $ 95.02万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10928602
• 关键词: Absence of pain sensation; Analgesics; Anesthesia and Analgesia; Anesthesia procedures; Anesthetics; Animal Experimentation; Animals; Antibiotics; Corticosterone; Distress; Dose; Ensure; Ethics; Feces; Goals; Health; Human; Intramural Research Program; Laboratories; Laws; Low-Level Laser Therapy; Methods; Modeling; Mus; National Institute of Environmental Health Sciences; Operative Surgical Procedures; Pain; Personal Satisfaction; Rattus; Research; Research Personnel; Research Subjects; Rodent; Safety; Science; Serum; Surgeon; Techniques; Tissues; behavior test; gut microbiota; improved; meter; pain relief; programs; skills; surgical service

Animal research is important in the advancement of of science, human and animal health. Refinement on animal research examines ways to minimize pain and distress as enhancing the well-being of our research animals. Anesthetics and analgesics are important components of an animal research program. It is required by law and it is our ethical responsibility to avoid and minimize pain and distress in animals undergoing research. NIEHS has a strong rodent surgery core that provides surgical services to those investigators whose research requires rodent surgery. All surgeons are well skilled with aseptic technique, gentle tissue handling, and rodent surgery in general. Part of the surgery planning is to provide adequate and complete anesthesia and analgesia. It is also important that the selection of the anesthetic or analgesic not interfere with the research goal. The research in ES102825-01 investigates the efficacy, safety, duration of effect, and reliability of various types of anesthetics and analgesics. This research broadens our understanding of anesthetics and analgesics in mice and rats-ensuring adequate pain relief without interfering with the principle animal users research. We evaluate commercially available veterinary products as well as investigating new ways of compounding analagesics for longer duration of action. We examine other methods of analgesia (LASER therapy) as well as rodent cage enrichment.

动物研究在科学，人类和动物健康的发展中很重要。 对动物研究的改进研究了将痛苦和困扰最小化的方法，以增强我们的研究动物的福祉。麻醉和镇痛药是动物研究计划的重要组成部分。 法律要求这是我们的道德责任，避免并最大程度地减少正在进行研究的动物的痛苦和困扰。 NIEHS具有强大的啮齿动物手术核心，可为那些需要啮齿动物手术的研究人员提供手术服务。所有外科医生都擅长于无菌技术，温和的组织处理和啮齿动物手术。手术计划的一部分是提供足够的完整麻醉和镇痛。 同样重要的是，选择麻醉或止痛药不会干扰研究目标。 ES102825-01中的研究调查了各种麻醉和镇痛药的功效，安全性，效果持续时间和可靠性。 这项研究扩大了我们对小鼠麻醉和镇痛药的理解，并可以减轻足够的疼痛缓解，而不会干扰主要动物使用者的研究。 我们评估了商业上可用的兽医产品，并研究了更长的动作时间复杂衡量方法的新方法。 我们检查了其他镇痛（激光疗法）以及啮齿动物笼富集的方法。

项目成果

The effects of perioperative analgesia on litter size in Crl:CD1(ICR) mice undergoing embryo transfer.

围手术期镇痛对接受胚胎移植的 Crl:CD1(ICR) 小鼠产仔数的影响。

• 发表时间: 2010
• 期刊: Journal of the American Association for Laboratory Animal Science : JAALAS
• 作者: Goulding,DavidR;Myers,PageH;Goulding,EugeniaH;Blankenship,TerryL;Grant,MaryF;Forsythe,DianeB
• 通讯作者: Forsythe,DianeB