Animal Refinement for Laboratory Rodents

实验室啮齿动物的动物精炼

• 批准号: 10252591
• 负责人: Terry Blankenship-Paris
• 金额: $ 149.44万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10252591
• 关键词: Absence of pain sensation; Analgesics; Anesthesia and Analgesia; Anesthesia procedures; Anesthetics; Animal Experimentation; Animals; Antibiotics; Corticosterone; Distress; Dose; Ensure; Ethics; Feces; Goals; Health; Human; Intramural Research Program; Laboratories; Laws; Methods; Modeling; Mus; National Institute of Environmental Health Sciences; Operative Surgical Procedures; Pain; Palate; Personal Satisfaction; Rattus; Research; Research Personnel; Research Subjects; Rodent; Safety; Science; Serum; Surgeon; Techniques; Tissues; behavior test; gut microbiota; improved; meter; pain relief; programs; surgical service

Animal research is important in the advancement of of science, human and animal health. Refinemtn on animal research examines ways to minimize pain and distress as enhancing the well-being of our research animals. Anesthetics and analgesics are important components of an animal research program. It is required by law and it is our ethical responsibility to avoid and minimize pain and distress in animals undergoing research. NIEHS has a strong rodent surgery core that provides surgical services to those investigators whose research requires rodent surgery. All surgeons are well skilled with aseptic technique, gentle tissue handling, and rodent surgery in general. Part of the surgery planning is to provide adequate and complete anesthesia and analgesia. It is also important that the selection of the anesthetic or analgesic not interfere with the research goal. The research in ES102825-01 investigates the efficacy, safety, duration of effect, and reliability of various types of anesthetics and analgesics. This research broadens our understanding of anesthetics and analgesics in mice and rats-ensuring adequate pain relief without interfering with the principle animal users research. We evaluate commercially available veterinary products as well as investigating new ways of compounding analagesics for longer duration of action. We examine other methods of analgesia (LASER therapy) as well as rodent cage enrichment.

动物研究对于科学进步、人类和动物健康非常重要。 动物研究的精炼研究了如何最大限度地减少疼痛和痛苦，同时提高我们的研究动物的福祉。麻醉剂和镇痛剂是动物研究计划的重要组成部分。 这是法律要求的，也是我们的道德责任，避免和尽量减少接受研究的动物的痛苦和痛苦。 NIEHS 拥有强大的啮齿动物手术核心，为那些需要啮齿动物手术的研究人员提供手术服务。所有外科医生都精通无菌技术、温和的组织处理和一般啮齿动物手术。手术计划的一部分是提供充分且完整的麻醉和镇痛。 同样重要的是麻醉剂或镇痛剂的选择不要干扰研究目标。 ES102825-01 中的研究调查了各类麻醉剂和镇痛剂的功效、安全性、作用持续时间和可靠性。 这项研究拓宽了我们对小鼠和大鼠麻醉剂和镇痛剂的理解，确保充分缓解疼痛，而不干扰主要的动物使用者研究。 我们评估市售兽药产品，并研究复合镇痛药以延长作用时间的新方法。 我们研究了其他镇痛方法（激光疗法）以及啮齿动物笼浓缩方法。