Analgesia and Anesthesia for Laboratory Rodents

实验室啮齿动物的镇痛和麻醉

• 批准号: 8734167
• 负责人: Terry Blankenship-Paris
• 金额: $ 20.38万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8734167
• 关键词: Analgesics; Anesthesia and Analgesia; Anesthetics; Animal Experimentation; Animals; Buprenorphine; Corticosterone; Distress; Dose; Ensure; Ethics; Feces; Gel; Goals; Intramural Research Program; Laboratories; Laws; Methods; Modeling; Mus; National Institute of Environmental Health Sciences; Operative Surgical Procedures; Pain; Personal Satisfaction; Pluronics; Rattus; Research; Research Personnel; Research Subjects; Rodent; Safety; Serum; behavior test; improved; meter; programs; surgical service

Anesthetics and analgesics are important components of an animal research program. It is required by law and it is our ethical responsibility to avoid and minimize pain and distress in animals undergoing research. NIEHS has a strong rodent surgery core that provides surgical services to those investigators whose research requires rodent surgery. It is important for adequate and complete anesthesia and analgesia be provided for the animal's well-being;however it is also important that the selection of the anesthetic or analgesic not interfere with the research goal. The research in ES102825-01 investigates the efficacy, safety, duration of effect, and reliability of various types of anesthetics and analgesics. This research broadens our understanding of anesthetics and analgesics in mice and rats-ensuring adequate pain relief without interfering with the principle animal users research. We evaluate commercially available veterinary products as well as investigating new ways of compounding analagesics for longer duration of action. Recently we have been investigating the use of pluronic gel in providing a sustained release buprenorphine compound

麻醉剂和镇痛剂是动物研究计划的重要组成部分。 这是法律要求的，也是我们的道德责任，避免和尽量减少接受研究的动物的痛苦和痛苦。 NIEHS 拥有强大的啮齿动物手术核心，为那些需要啮齿动物手术的研究人员提供手术服务。 为动物的健康提供充分和完整的麻醉和镇痛非常重要；然而，麻醉剂或镇痛剂的选择不干扰研究目标也很重要。 ES102825-01 中的研究调查了各类麻醉剂和镇痛剂的功效、安全性、作用持续时间和可靠性。 这项研究拓宽了我们对小鼠和大鼠麻醉剂和镇痛剂的理解，确保充分缓解疼痛，而不干扰主要的动物使用者研究。 我们评估市售兽药产品，并研究复合镇痛药以延长作用时间的新方法。 最近我们一直在研究使用普朗尼克凝胶来提供缓释丁丙诺啡化合物