STUDY OF PREGNANCY AND NEONATAL HEALTH (SPAN) SPECIMEN REPOSITORY

妊娠和新生儿健康研究（SPAN）样本库

• 批准号: 10927705
• 负责人: BRITTANY MARTIN
• 金额: $ 32.19万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-12 至 2026-09-11
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10927705
• 关键词: Acceleration; Affect; African American population; Age; Anthropometry; Attention; Bar Codes; Biological Specimen Banks; Birth; Cardiovascular Diseases; Data; Development; Disease; Ensure; Epigenetic Process; Equipment and supply inventories; Erythrocytes; Fetal Growth; Future; Gene Expression; Genetic; Gestational Age; Hair; Health; Link; Mental disorders; Neonatal; Online Systems; Pathway interactions; Perinatal mortality demographics; Plasma; Pregnant Women; Research; Saliva; Sampling; Seminal fluid; Serum; Services; Specimen; System; Time; Tube; assault; cardiovascular risk factor; delivery complications; father role; fetal; genetic approach; genome wide association study; genomic locus; male; neonatal health; neonatal morbidity; neonatal outcome; neonate; pregnancy health; prenatal; recruit; repository

The timing of delivery (i.e., gestational age) and birth size are important neonatal outcomes for future health, affecting a range of conditions from mental disorders to cardiovascular disease. Research into the Developmental Onset of Health and Disease (DOHaD) evolved upon recognizing that birth size reflects fetal growth. Hence, attention has been paid to the timing of prenatal assaults as well as the type of assault for the resulting birth size, timing of delivery and their intersection (i.e., size for gestational age). More recently, DOHaD and complementary genetic approaches offer opportunities to understand environmental and genetic mechanisms that underpin key pathways important for health and disease. examine critical data gaps motivated by DOHaD, including the father's role, placental determinants, and timing of delivery in relation to neonatal health and development. The SPAN study encompasses three major aims: Aim 1: To determine whether paternal cardiovascular risk factors are associated with fetal growth, neonatal anthropometry, and placental function; and whether semen epigenetic differences explain any of these associations. Aim 2: To conduct a genome-wide association study to identify fetal genetic loci that influence fetal growth and birth anthropometry, and to determine fetal genetic loci associated with placental age acceleration and the functional link between associated genetic loci, placental gene expression and fetal growth in African Americans. Aim 3: To determine the optimal time for GDM complicated deliveries between 37-39 weeks where neonatal morbidity and perinatal mortality is the lowest SPAN will recruit 10,792 pregnant women, their neonates (10,253), and 3825 (~35%) of their male partners.

分娩的时间（即胎龄）和出生率是未来健康的重要新生儿结果，影响了从精神障碍到心血管疾病的一系列疾病。对健康和疾病（DOHAD）发育的研究随着意识到出生的规模反映了胎儿的生长而进化。因此，注意力集中在产前攻击的时机以及产生的出生规模，分娩时机及其交叉点（即妊娠年龄的大小）的攻击类型。最近，多哈德（Dohad）和互补的遗传方法提供了理解基于关键的环境和遗传机制的机会 对健康和疾病重要的途径。检查DOHAD动机的关键数据差距，包括父亲的角色，胎盘决定因素以及与新生儿健康和发展有关的交付时间。 跨度研究包括三个主要目的： 目标1：确定父亲心血管危险因素是否与胎儿生长，新生儿人体测量法和胎盘功能有关；精液表观遗传学差异是否解释了这些关联。 目的2：进行全基因组关联研究，以识别影响胎儿生长和出生人体测量法的胎儿遗传基因座，并确定与胎盘年龄加速度相关的胎儿遗传基因座，以及相关的遗传基因座，胎盘基因表达和非裔美国人的相关遗传基因座表达和胎儿生长之间的功能联系。 AIM 3：确定GDM复杂交付的最佳时间在37-39周之间，新生儿的发病率和围产期死亡率是最低的跨度将招募10,792名孕妇，新生儿（10,253）和3825（约35％）（约35％）。