NICHD HUMAN BIOSPECIMEN REPOSITORY – MPIDB PHACS HOPE SPECIMEN

NICHD 人类生物样本存储库 — MPIDB PHACS HOPE 样本

• 批准号: 10929282
• 负责人: BRITTANY MARTIN
• 金额: $ 5.45万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-06 至 2024-09-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10929282
• 关键词: 18 year old; Adolescent; Age; Bar Codes; Biological Specimen Banks; Cataloging; Child; Childhood; Clinical; Clinical Research; Cohort Studies; Communicable Diseases; Contracts; Data; Database Management Systems; Eligibility Determination; Enrollment; Ensure; Equipment; Equipment and supply inventories; Exposure to; Family; Future; HIV; HIV-exposed uninfected infant; HIV/AIDS; Health; Human; Human Resources; Individual; Infant; Monitor; National Institute of Child Health and Human Development; Online Systems; Outcome; Perinatal; Pregnancy; Protocols documentation; Regulation; Reproductive Health; Research; Research Activity; Sampling; Secure; Services; Shipping; Site; Specimen; Support System; System; Toxic effect; Tube; United States; Woman; Youth; computerized; experience; improved; operation; pediatric human immunodeficiency virus; perinatal HIV; pregnant; programs; quality assurance; repository; reproductive; young woman

The Maternal and Pediatric Infectious Disease Branch (MPIDB) promotes research to investigate the impact and treatment of HIV, its complications, and other significant infectious diseases in infants, children, adolescents, and pregnant and nonpregnant women. This includes contracted clinical research activities conducted primarily in two major networks that actively collect specimens to be housed in the NICHD repository. These are the Pediatric HIV AIDS Cohort Study (PHACS). PHACS is a multicenter United States-based program that follows both perinatally HIV-infected youth and HIV-exposed/uninfected infants, children, and youth. PHACS currently includes four main protocols and four sub studies. A wide variety of specimen types are collected at 18 SMARTT (Surveillance Monitoring for ART Toxicities Study in HIV-uninfected Children Born to HIV-infected Women) and 14 AMP (Adolescent Master Protocol) current study sites that require repository services. The Health Outcomes around Pregnancy and Exposure to HIV/ARVs (HOPE) explores reproductive health choices, including pregnancy, and overall health outcomes, including reproductive health outcomes. HOPE provides the opportunity to inform future advancements for women living with HIV and their families.

孕产妇和小儿传染病分支（MPIDB）促进了研究，以研究艾滋病毒的影响和治疗，其并发症以及其他重大的感染性疾病对婴儿，儿童，青少年以及怀孕和未怀孕的妇女。这包括主要在两个主要网络中进行的合同临床研究活动，这些网络积极收集了在NICHD存储库中容纳的标本。这些是小儿艾滋病毒艾滋病队列研究（PHACS）。 PHACS是一项基于美国的多中心计划，遵循周围感染HIV的青年和受HIV暴露/未感染的婴儿，儿童和青年。 PHAC当前包括四个主要方案和四项子研究。在18 Smartt（艾滋病毒感染的妇女出生的艾滋病毒未感染儿童中对ART毒性研究的监视监测研究）和14个AMP（青少年主协议）当前的研究站点，需要进行多种样本类型（对ART毒性的监测监测）。 怀孕和暴露于HIV/ARVS（HOPE）的健康结果探讨了生殖健康的选择，包括怀孕和整体健康结果，包括生殖健康结果。希望为艾滋病毒及其家人的妇女提供未来进步的机会。