Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center

肠干细胞联盟协调中心延续有限竞争

基本信息

批准号：
10921909
负责人：
Joyce Carol Niland
金额：
$ 8.93万
依托单位：
BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10921909
关键词：
Acceleration Affect Applications Grants Biocompatible Materials Biometry Cells Cities Collaborations Collection Communities Data Data Analyses Data Set Development Digestive System Disorders Disease Ensure Fostering Funding Gastrointestinal Diseases Gastrointestinal tract structure Goals Growth Factor Health Homeostasis Human Image Infection Injury Intestines Investigation Knowledge Lead Maintenance Methods Mission Modeling Natural regeneration Online Systems Patients Persons Pharmaceutical Preparations Pilot Projects Policies Population Protocols documentation Publications RNA Interference Radiation Reagent Regenerative capacity Research Research Design Research Infrastructure Research Personnel Research Project Grants Research Support Resource Sharing Resources Sample Size Science Scientific Advances and Accomplishments Specific qualifier value Standardization Stem Cell Research Teleconferences Therapeutic Transplantation United States National Institutes of Health Vision chemotherapy design epithelial injury epithelium regeneration experience gastrointestinal system intestinal epithelium meetings member morphogens multidisciplinary new therapeutic target preclinical study programs regeneration potential stem cell biology stem cells tool web site working group

项目摘要

PROJECT SUMMARY/ ABSTRACT The overall objective of the Intestinal Stem Cell Consortium Coordinating Center (ISCC CC) is to maximize scientific exchange and accelerate research, information, data, biomaterials, models, reagents, resources and methods shared within the ISCC and with the research community. The goal of this grant proposal is to continue to maintain and enhance the ISCC CC at City of Hope for another 5 years, working with investigators from 9 Research Centers across the nation chosen by NIH to pursue the vision of developing novel therapies targeting intestinal stem cells and their supportive niche to regenerate and rebuild the human intestine. To achieve its mission of characterizing the minimal, required niche factors that support intestinal stem cells in health and disease, the ISCC utilizes an integrated, multidisciplinary team science approach, which is a network of synergistic projects focused on the following 3 Goals: Goal 1: To define essential niche components that contribute to intestinal epithelial homeostasis, Goal 2: To determine niche components that are altered following injury (infection, chemotherapy, radiation) and evaluate whether they play a role in epithelial regeneration, and Goal 3: To develop a therapeutic approach for epithelial injury, using transplant, drugs, growth and/or differentiating factors. The ISCC CC at COH is fully poised to continue to provide optimal research infrastructure and support to the ISCC through the following specific aims: 1) To facilitate the necessary team science administration of the ISCC; 2) To advance the collaborative science of the ISCC by providing study development and analysis; 3) To coordinate standardized resources across the Consortium; and 4) To provide data and information sharing within the ISCC and across the research community.

项目概要/摘要肠道干细胞联盟协调中心 (ISCC CC) 的总体目标是最大化科学交流并加速研究、信息、数据、生物材料、模型、试剂、资源以及 ISCC 内部和研究界共享的方法。该拨款提案的目标是继续在希望之城维持和加强 ISCC CC 再五年，与 NIH 选择来自全国 9 个研究中心的研究人员来追求开发新颖的愿景针对肠道干细胞及其支持性生态位的疗法，以再生和重建人类肠道。为了实现其使命，即描述支持肠道干细胞的最小的、必需的利基因子。健康和疾病方面，ISCC 采用综合的、多学科的团队科学方法，这是一种协同项目网络侧重于以下 3 个目标：目标 1：定义必要的利基组成部分有助于肠上皮稳态，目标 2：确定发生改变的生态位成分损伤后（感染、化疗、放疗）并评估它们是否在上皮细胞中发挥作用再生，目标 3：开发一种治疗上皮损伤的方法，利用移植、药物、生长和/或差异化因素。 COH 的 ISCC CC 已做好充分准备，继续提供最佳研究通过以下具体目标为 ISCC 提供基础设施和支持： 1) 促进必要的团队 ISCC 的科学管理； 2) 通过提供研究来推进 ISCC 的协作科学开发和分析； 3）协调整个联盟的标准化资源； 4) 提供 ISCC 内部和整个研究界的数据和信息共享。