Human Islet Research Network (HIRN) Coordinating Center

人类胰岛研究网络 (HIRN) 协调中心

• 批准号: 8813276
• 负责人: Joyce Carol Niland
• 金额: $ 99.94万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8813276
• 关键词: Advisory Committees; Beta Cell; Biocompatible Materials; Bioinformatics; Biological; Biomedical Research; Cataloging; Catalogs; Cell Line; Cities; Collaborations; Communication; Communities; Data; Databases; Development; Diabetes Mellitus; Digestive System Disorders; Doctor of Philosophy; Electronics; Ensure; Environment; Familiarity; Fostering; Funding; Future; Goals; Growth; Human; Imagery; Information Sciences; Information Systems; Institutes; Insulin-Dependent Diabetes Mellitus; Investments; Kidney Diseases; Knowledge; Leadership; Link; Metadata; Mission; Monitor; N.I.H. Research Support; National Institute of Diabetes and Digestive and Kidney Diseases; Office of Administrative Management; Online Systems; Participant; Policies; Prevention; Principal Investigator; Procedures; Process; Qualifying; Reagent; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Role; Science; Scientific Advances and Accomplishments; Scientist; Support System; Teleconferences; Tissue Donors; Translational Research; Trust; U-Series Cooperative Agreements; United States National Institutes of Health; Work; base; data sharing; experience; flexibility; forging; functional loss; induced pluripotent stem cell; innovation; islet; material transfer agreement; meetings; member; next generation; operation; professor; programs; public health relevance; repository; software systems; success; tool; treatment strategy; web site; working group

 DESCRIPTION (provided by applicant): City of Hope (COH) is applying to serve as the Human Islet Research Network (HIRN) Coordinating Center (HIRN-CC), to support HIRN's goal of developing innovative strategies for the treatment, prevention and cure of Type 1 Diabetes (T1D). The HIRN-CC will provide critical infrastructure to promote communication and collaboration among current and future HIRN participants, facilitating scientific advances and fostering the sharing of data, tools, and reagents among HIRN members and the research community at large. To support the HIRN mission, the HIRN-CC will work collaboratively with the HIRN Bioinformatics Center (HIRN-BC) to form the HIRN Administrative Hub, under the guidance of the HIRN advisory committees and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Our highly qualified Principal Investigator (PI) and staff will apply their extensive experience with administrative management of resource-based operations serving the biomedical research community, leveraging ongoing NIDDK support to optimize the value to the HIRN, incorporating our familiarity with the UC4 cooperative mechanism, and a diverse portfolio of successfully deployed biomedical research support systems, websites, and multi-center databases. Through the HIRN-CC, COH will provide an optimal administrative infrastructure for the HIRN, including arranging all meetings and teleconferences of the multiple advisory groups; preparing agendas, meeting materials and drafting minutes; documenting policies and procedures for the program; and issuing "opportunity pool" subcontracts. COH will foster an environment of trust and cooperation among participating HIRN consortia members to maximize information and resource sharing, thereby accelerating team science and new advances. The CC will actively facilitate scientific communication through organization of an annual scientific retreat, encouraging discussion among participating investigators via 'chat' rooms, facilitating working groups, and networking and collaborations among other NIH programs and non-NIH partners. In establishing a strong collaborative with the HIRN-BC, COH will promote sharing of data, materials and resources across the HIRN Consortia and the T1D scientific community through development of a leading edge HIRN website and data repository linkage. HIRN consortia members will benefit by cataloguing, searching, and exchanging biomaterials via the COH-developed electronic Material Transfer Agreement (eMTA) software system, facilitating streamlined transfer of materials among Consortia membership. The CC will develop search and visualization tools for investigators to readily access validated data and metadata generated by HIRN research projects, and link HIRN databases to relevant NIH data repositories and websites to eliminate duplication. The HIRN-CC will forge partnerships with related initiatives such as the Integrated Islet Distribution Program (IIDP) to leverage existing resources. COH is fully poised to assume all HIRN-CC responsibilities to support and enhance the HIRN initiative, while remaining flexible in accommodating the changing TID scientific environment and emerging research needs.

 描述（由申请人提供）：希望之城 (COH) 正在申请成为人类胰岛研究网络 (HIRN) 协调中心 (HIRN-CC)，以支持 HIRN 制定治疗、预防和治愈胰岛问题的创新策略的目标1 型糖尿病 (T1D) HIRN-CC 将提供关键基础设施，以促进当前和未来 HIRN 参与者之间的沟通和协作，促进科学进步并促进数据、工具和技术的共享。为了支持 HIRN 使命，HIRN-CC 将与 HIRN 生物信息学中心 (HIRN-BC) 合作，在 HIRN 咨询委员会和 HIRN 的指导下组建 HIRN 管理中心。国家糖尿病、消化和肾脏疾病研究所 (NIDDK)。我们高素质的首席研究员 (PI) 和工作人员将运用他们在基于资源的运营的行政管理方面的丰富经验。服务生物医学研究界，利用 NIDDK 的持续支持来优化 HIRN 的价值，结合我们对 UC4 合作机制的熟悉，以及通过 HIRN 成功部署的生物医学研究支持系统、网站和多中心数据库的多样化组合。 -CC、COH 将为 HIRN 提供最佳的行政基础设施，包括安排多个咨询小组的所有会议和电话会议；准备议程、会议材料和起草该计划的政策和程序；颁发“机会池”分包合同将在参与的 HIRN 联盟成员之间营造一个信任与合作的环境，以最大限度地实现信息和资源共享，从而加速团队科学和新进展。CC 将通过组织年度科学活动积极促进科学交流。 COH 将通过“聊天室”鼓励参与研究人员进行讨论、促进工作组以及其他 NIH 项目和非 NIH 合作伙伴之间的网络和合作。通过开发领先的 HIRN 网站和数据存储库链接，HIRN 联盟和 T1D 科学界的材料和资源将受益于通过 COH 开发的电子材料转移协议 (eMTA) 编目、搜索和交换生物材料。 CC 将开发搜索和可视化工具，以便研究人员能够轻松访问 HIRN 研究项目生成的经过验证的数据和元数据，并链接。 HIRN 数据库连接到相关 NIH 数据存储库和网站，以消除重复。 HIRN-CC 将与综合胰岛分布计划 (IIDP) 等相关举措建立合作伙伴关系，以充分利用现有资源，承担 HIRN-CC 的所有责任。支持和加强 HIRN 计划，同时保持灵活性，适应不断变化的 TID 科学环境和新出现的研究需求。