Rocky Mountain Neurological Disorders Core

落基山神经疾病核心

• 批准号: 8585905
• 负责人: Angeles Badell Ribera
• 金额: $ 72.33万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8585905
• 关键词: Animals; Area; Behavioral; Biological Models; Clinical; Core Facility; Electron Microscopy; Fostering; Gene Targeting; Generations; Genetic; Goals; Health; Medical; Microscopy; Mus; Names; Neurobiology; Neurosciences Research; Phenotype; Rattus; Research; Services; Transgenic Mice; Transgenic Organisms; Viral; Viral Vector; Zebrafish; design and construction; interest; light microscopy; meetings; molecular imaging; nervous system disorder; vector

This Is a competitive renewal of the Rocky Mountain Neurological Disorder Center (RMNOC) whose main goal Is to enhance and further research in areas of neurobiology targeted by the NINOS. The RMNO Center Core has established facilities that allow efficient generation and use of genetically-altered animals that display Interesting and Informative functional or behavioral phenotypes. Our existing cores have all been extremely successful and evolved to enable state-of-the-art approaches thereby allowing users to perform collaborative research in an efficient manner. Therefore, we propose to maintain the original cores with their original names, emphasizing that they will continue to evolve over the next five years, as described in the application (Cores A, 6, C, and 0). As before, the services provided by the four cores are not available elsewhere at the Anschutz Medical Campus. We propose four core facilities for the RMNO Center Core: Core A Microscopy Core (Bill Betz, Director) will provide advanced light and electron microscopy services. Core B Gene-Targeting/Viral Vector Core (Mark Dell'Acqua, Director) \N\\\ design and construct vectors to generate gene-targeted and transgenic mice as well as viral targeting vectors. Core CZebrafish Transgenic Core (Angeles Ribera, Director)m\\ provide services for maintaining and characterizing transgenic zebraflsh. Core D Machine Shop Core (Ulli Bayer, Director) will provide machine shop support services.

这是落基山神经疾病中心 (RMNOC) 的竞争性更新，其主要目标 旨在加强和进一步 NINOS 所针对的神经生物学领域的研究。 RMNO 中心核心 已经建立了设施，可以有效地产生和使用转基因动物，这些动物表现出 有趣且信息丰富的功能或行为表型。我们现有的核心都非常 成功并不断发展以实现最先进的方法，从而允许用户执行协作 以有效的方式进行研究。因此，我们建议保留原来的核心及其原来的名称， 强调它们将在未来五年内继续发展，如申请中所述（核心 A、 6、C 和 0)。和以前一样，四个核心提供的服务是 Anschutz 其他地方无法提供的 医学校区。 我们为 RMNO 中心核心提出四个核心设施： 核心 A 显微镜核心（Bill Betz，总监）将提供先进的光学和电子显微镜服务。 核心 B 基因靶向/病毒载体核心（Mark Dell'Acqua，总监）\N\\\ 设计和构建载体 产生基因靶向和转基因小鼠以及病毒靶向载体。 Core CZebrafish Transgenic Core（Angeles Ribera，总监）m\\ 提供维护和 表征转基因斑马鱼。 Core D Machine Shop Core（Ulli Bayer，总监）将提供机加工车间支持服务。