Rocky Mountain Neurological Disorders Core Center

落基山神经疾病核心中心

基本信息

批准号：
7283677
负责人：
Angeles Badell Ribera
金额：
$ 71.31万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-15 至 2009-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7283677
关键词：
Rocky Mountain Neurological Disorders Core

项目摘要

DESCRIPTION (provided by applicant): This application requests funding for the Rocky Mountain Neurological Disorders Core Center, a facility with the aim of providing services for NINDS-funded investigators at UCHSC focused on the use of protein fluorescent indicators in vivo in mice and zebrafish. The combination of animal model systems and modern microscopy techniques is expected to result in a core center that will catalyze exciting new collaborative research projects within a group of already outstanding investigators. The facility will be directed by Dr. Angeles Ribera who will be assisted by a steering committee made up of the Directors of each core. Core usage will be prioritized as a function of previous usage of the core by each investigator. The facility will be housed in brand new space in the new Fitzsimons campus of the UCHSC. The following are the individual cores: Core A Microscopy Core (Bill Betz, Director) will provide advanced light and electron microscopy services. Core B Gene-Targeting/Viral Vector Core (Mark Dell'Acqua, Director) will design and construct vectors to generate gone-targeted and transgenic mice as well as viral targeting vectors. Core C Zebrafish Transgenic Core (Angeles Ribera, Director) will provide services for the generation and maintenance of transgenic zebrafish. Core D Machine Shop (John Caldwell, Director) will provide machine shop and computer services.

描述（由申请人提供）：该申请请求为落基山神经疾病核心中心提供资金，该中心旨在为 UHSC 的 NINDS 资助的研究人员提供服务，重点关注小鼠和斑马鱼体内蛋白质荧光指示剂的使用。动物模型系统和现代显微镜技术的结合预计将形成一个核心中心，该中心将促进一群已经非常出色的研究人员开展令人兴奋的新合作研究项目。该设施将由 Angeles Ribera 博士领导，他将得到由每个核心董事组成的指导委员会的协助。核心使用情况将根据每个研究者之前对核心的使用情况进行优先排序。该设施将坐落在 UHSC 菲茨西蒙斯新校区的全新空间内。以下是各个核心：核心 A 显微镜核心（Bill Betz，总监）将提供先进的光学和电子显微镜服务。核心 B 基因靶向/病毒载体核心（Mark Dell'Acqua，总监）将设计和构建载体以生成脱靶和转基因小鼠以及病毒靶向载体。 Core C 斑马鱼转基因核心（Angeles Ribera，主任）将为转基因斑马鱼的产生和维持提供服务。 Core D Machine Shop（总监 John Caldwell）将提供机械车间和计算机服务。