Rocky Mountain Neurological Disorders Core

落基山神经疾病核心

基本信息

批准号：
8374791
负责人：
Angeles Badell Ribera
金额：
$ 4.17万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-15 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8374791
关键词：
Animal Model Animals Appointment Area Award Basic Science Behavioral Biochemistry Biological Models Biophysics Clinical Collaborations Colorado Core Facility Developmental Cell Biology Disease Electron Microscopy Epilepsy Faculty Fluorescence Fostering Funding Gene Targeting Generations Genetic Goals Ice Individual Instruction Laboratories Measurement Medical Microbiology Microscopy Molecular Mus Names National Institute of Neurological Disorders and Stroke Neurobiology Neurosciences Neurosciences Research Pediatric Neurology Pharmacologic Substance Pharmacology Pharmacy Schools Phenotype Physiology Positioning Attribute Rattus Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Research Support Rodent Science Secure Seizures Services Techniques Transgenic Mice Transgenic Organisms Translational Research Universities Ursidae Family Viral Viral Vector Zebrafish base design and construction experience interest light microscopy medical schools meetings molecular imaging nervous system disorder positional cloning professor programs synaptic function translational neuroscience translational study vector

项目摘要

PROJECT SUMMARY (See instructions): This Is a competitive renewal of the Rocky Mountain Neurological Disorder Center (RMNOC) whose main goal Is to enhance and further research in areas of neurobiology targeted by the NINOS. The RMNO Center Core has established facilities that allow efficient generation and use of genetically-altered animals that display Interesting and Informative functional or behavioral phenotypes. Our existing cores have all been extremely successful and evolved to enable state-of-the-art approaches thereby allowing users to perform collaborative research in an efficient manner. Therefore, we propose to maintain the original cores with their original names, emphasizing that they will continue to evolve over the next five years, as described in the application (Cores A, 6, C, and 0). As before, the services provided by the four cores are not available elsewhere at the Anschutz Medical Campus. We propose four core facilities for the RMNO Center Core: Core A Microscopy Core (Bill Betz, Director) will provide advanced light and electron microscopy services. Core B Gene-Targeting/Viral Vector Core (Mark Dell'Acqua, Director) \N\\\ design and construct vectors to generate gene-targeted and transgenic mice as well as viral targeting vectors. Core C Zebrafish Transgenic Core (Angeles Ribera, Director)m\\ provide services for maintaining and characterizing transgenic zebraflsh. Core D Machine Shop Core (Ulli Bayer, Director) will provide machine shop support services.

项目摘要（参见说明）：这是落基山神经疾病中心 (RMNOC) 的竞争性更新，其主要目标是加强和进一步研究 NINOS 所针对的神经生物学领域。 RMNO 中心核心已建立设施，可有效生成和使用显示出有趣且信息丰富的功能或行为表型的基因改造动物。我们现有的核心都非常成功并不断发展以实现最先进的方法，从而允许用户以有效的方式进行协作研究。因此，我们建议保留原始核心的原始名称，强调它们将在未来五年内继续发展，如申请中所述（核心 A、6、C 和 0）。和以前一样，四个核心提供的服务是 Anschutz 其他地方无法提供的医学校区。我们为 RMNO 中心核心提出四个核心设施：核心 A 显微镜核心（Bill Betz，总监）将提供先进的光学和电子显微镜服务。核心B 基因靶向/病毒载体核心（Mark Dell'Acqua，主任）\N\\\设计和构建载体以产生基因靶向和转基因小鼠以及病毒靶向载体。 Core C 斑马鱼转基因核心（Angeles Ribera，主任）提供转基因斑马鱼的维护和表征服务。 Core D Machine Shop Core（Ulli Bayer，总监）将提供机加工车间支持服务。