Multifrequency ultrasound imaging for improved breast tissue characterization

多频超声成像可改善乳腺组织特征

基本信息

批准号：
10904411
负责人：
Kenneth Hoyt
金额：
$ 55.54万
依托单位：
TEXAS ENGINEERING EXPERIMENT STATION
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-15 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10904411
关键词：
Acoustics Animal Model Animals Antineoplastic Agents Apoptosis Apoptotic Biological Process Breast Cancer Model Breast Cancer Treatment Bypass Cell Aggregation Cell Death Cell Nucleus Cell Size Cell Survival Cells Characteristics Classification Clinic Clinical Clinical Research Color Custom Data Dependence Diffusion Magnetic Resonance Imaging Discrimination Disease Management Dose Drug resistance Early Diagnosis Early treatment Environment Exhibits Frequencies Goals Health Histologic Hormones Image Imaging Techniques Imaging technology In complete remission Induction of Apoptosis Knowledge Localized Malignant Neoplasm Magnetic Resonance Imaging Malignant Neoplasms Mammary Gland Parenchyma Mammary Neoplasms Measurement Measures Methods Modality Monitor Neoadjuvant Therapy Nuclear Operative Surgical Procedures Output Pathologic Pathology Patients Pattern Pharmaceutical Preparations Physiologic pulse Play Pre-Clinical Model Property Recurrence Research Research Project Grants Resolution Role Scanning Series Signal Transduction Structure System Techniques Technology Testing Therapeutic Time Tissue Sample Tissues Transducers Transgenic Animals Treatment Failure Treatment Protocols Ultrasonic Transducer Ultrasonic wave Ultrasonography attenuation breast imaging cancer cell cancer therapy chemotherapy clinical imaging deep learning algorithm design human disease human study imaging approach imaging system improved in vivo innovation irradiation malignant breast neoplasm neoplastic cell next generation non-invasive imaging pre-clinical prevent quantitative ultrasound real-time images response routine imaging soft tissue standard of care success targeted imaging theories transmission process treatment response tumor ultrasound

项目摘要

PROJECT SUMMARY The use of noninvasive ultrasound for quantitative tissue characterization has been an exciting research prospect for several decades now. Herein the challenge is to find hidden patterns in the ultrasound data to reveal more information about tissue function and pathology that cannot be seen in the more conventional ultrasound images. Bypassing some of the limitations associated with traditional tissue characterization approaches, a new modality has emerged for the ultrasound classification of acoustic scatterers like cancer cells. Termed H-scan ultrasound (where the ‘H’ stands for Hermite or hue), this innovative real-time imaging technique reveals the local frequency dependence of different-sized scatterer aggregates found in soft tissue. Our preliminary preclinical findings using in vivo H-scan ultrasound have indicated that this new imaging technique is useful for detecting apoptotic activity and an early response to chemotherapy. Here changes in H-scan ultrasound image intensity were shown to have a strong correlation to local cancer cell nuclear size. Guided by knowledge gained from these previous studies, the purpose of the current research project is to develop a next-generation in vivo H-scan ultrasound imaging system and tumor characterization method. Our first goal is to implement a multifrequency H-scan ultrasound imaging functionality on programmable scanner equipped with a wideband capacitive micromachined ultrasonic transducer (CMUT). This new ultrasound imaging technology will be tested and optimized using a series of phantom materials embedded with scatterers of known size. Next, we will quantify success of H-scan ultrasound imaging for monitoring an early response to chemotherapy using a preclinical model of breast cancer that recapitulates human disease. We will then compare H-scan ultrasound findings to physical measurements of cancer cell size and results obtained by competing imaging technologies. Lastly, we will conduct the first human study of multifrequency H-scan ultrasound imaging of breast cancer and evaluate the potential for helping with disease management.

项目摘要使用非侵入性超声来定量组织表征一直是令人兴奋的研究前景几十年来。在此，挑战是在超声数据中找到隐藏的模式以揭示更多有关组织功能和病理学的信息，这些信息在更传统的超声图像中无法看到。绕过与传统组织表征方法相关的一些限制，这是一种新的模式出现了用于癌细胞（例如癌细胞）的超声分类。称为H-SCAN超声（“ H”代表Hermite或Hue），这种创新的实时成像技术揭示了本地频率在软组织中发现的不同尺寸散点子聚集体的依赖性。我们使用的初步临床前发现体内H-SCAN超声表明这种新成像技术可用于检测凋亡活动以及对化学疗法的早期反应。这里显示了H-扫描超声图像强度的变化与局部癌细胞核大小有很强的相关性。以这些以前的知识为指导研究，当前研究项目的目的是开发体内H-SCAN超声的下一代成像系统和肿瘤表征方法。我们的第一个目标是实施多频H-scan 配备宽带电容微机械的可编程扫描仪上的超声成像功能超声传感器（CMUT）。这种新的超声成像技术将通过一系列的幻影材料嵌入了已知大小的散射器。接下来，我们将量化H-Scan的成功超声成像，用于使用乳腺癌的临床前模型监测对化学疗法的早期反应这概括了人类疾病。然后，我们将H-SCAN超声检查结果与物理测量结果进行比较通过竞争成像技术获得的癌细胞大小和结果。最后，我们将进行第一个人类对乳腺癌的多频H-SCAN超声成像的研究，并评估了帮助的潜力与疾病管理。