Multiparametric ultrasound imaging for early detection of nonalcoholic fatty liver disease

多参数超声成像用于早期检测非酒精性脂肪肝

• 批准号: 10320337
• 负责人: Kenneth Hoyt
• 金额: $ 40.17万
• 依托单位: UNIVERSITY OF TEXAS DALLAS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-21 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10320337
• 关键词: Address; Affect; Basic Science; Benign; Biological Markers; Blood flow; Caring; Cicatrix; Cirrhosis; Clinical; Coupling; Data; Development; Diagnosis; Discrimination; Disease; Disease Progression; Drug Industry; Early Diagnosis; Fatty acid glycerol esters; Fibrosis; Goals; Hepatocyte; Histologic; Human; Image; Imaging technology; Inflammation; Lead; Life; Life Style Modification; Link; Lipids; Liver; Liver Fibrosis; Liver diseases; Lobular; Measurement; Measures; Medical; Methods; Modeling; Monitor; Obesity Epidemic; Pathology; Patients; Pattern; Performance; Perfusion; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Prevalence; Primary carcinoma of the liver cells; Rattus; Research; Research Project Grants; Research Proposals; Risk; Sampling Errors; Savings; Severities; Staging; Surrogate Markers; Symptoms; System; Technology; Testing; Tissues; Ultrasonography; United States; Validation; Viscosity; base; biophysical model; chronic liver disease; clinical implementation; clinically translatable; comorbidity; contrast enhanced; cost; cost effective; data modeling; diet and exercise; disease diagnosis; drug candidate; elastography; imaging biomarker; imaging system; in vivo; innovation; liver biopsy; liver imaging; liver inflammation; liver transplantation; non-alcoholic fatty liver disease; nonalcoholic steatohepatitis; rapid growth; simple steatosis; ultrasound; virtual

PROJECT SUMMARY Liver disease is increasing in numbers and relevance across the globe. This disease causes no noticeable symptoms in many cases. After diagnosis, the costs associated with medical care are very high. Patients can be characterized on the nonalcoholic fatty liver disease (NAFLD) spectrum based on the progressive presence of steatosis (i.e. abnormal accumulation of fat within the liver), inflammation, ballooning, and then hepatic fibrosis. Despite the rapid growth and prevalence, the only therapy to treat NAFLD are lifestyle modifications, such as diet and exercise. While the pharmaceutical industry is actively pursuing the discovery and development of candidate drug therapies to address this unmet medical need, there is an urgent clinical need for the ability to noninvasively detect, accurately stage, and reliably monitor NAFLD. To that end, the goal of this research project is to develop a system and method for multiparametric ultrasound (mpUS) imaging of nonalcoholic fatty liver disease (NAFLD) including early pathology progression. Our preliminary findings strongly suggest that a single mpUS test that combines steatosis, ballooning, and inflammation information has the potential to provide a comprehensive estimation of the main components of early stage NAFLD. The main innovation of the proposed research project lies in the implicit link between biophysical models of NAFLD with these coordinated mpUS measurements. The first objective of this project is to develop an integrated ultrasound system and method for performing mpUS imaging. Then we will optimize this new imaging system in healthy rat liver. Lastly, we will evaluate mpUS imaging with a rat model of NAFLD that mirrors disease progression in humans. Here we will also optimize a biophysical model and longitudinal performance in the decision of NAFLD progression. If successful, this research will introduce and validate a safe, cost-effective mpUS imaging technology that can noninvasively detect, accurately stage, and reliably monitor NAFLD.

项目摘要 肝病的数量和相关性在全球范围内增加。这种疾病不会引起明显的明显 在许多情况下的症状。诊断后，与医疗相关的成本非常高。患者可以 基于非酒精性脂肪肝病（NAFLD）的特征 脂肪变性（即肝内脂肪的异常积累），炎症，气囊，然后是肝纤维化。 尽管迅速增长和患病率，但治疗NAFLD的唯一疗法是生活方式的改变，例如 饮食和运动。当制药行业正在积极追求发现和发展 候选药物疗法以满足这种未满足的医疗需求，紧急临床需要 非侵入性检测，准确分期并可靠地监测NAFLD。为此，该研究项目的目标 是开发一种非酒精脂肪肝的多组合超声（MPU）成像的系统和方法 疾病（NAFLD），包括早期病理进展。我们的初步发现强烈表明一个 结合脂肪变性，气球和炎症信息的MPU测试有可能提供 对早期NAFLD的主要组成部分的全面估计。提议的主要创新 研究项目在于NAFLD的生物物理模型与这些协调的MPU之间的隐式联系 测量。该项目的第一个目标是开发一个集成的超声系统和方法 执行MPU成像。然后，我们将在健康的大鼠肝脏中优化这种新成像系统。最后，我们会的 使用NAFLD的大鼠模型评估MPU成像，该模型反映了人类疾病进展。我们会在这里 还可以优化NAFLD进展决策中的生物物理模型和纵向性能。如果 成功的这项研究将介绍并验证一种安全，成本效益的MPU成像技术 非侵入性检测，准确分期并可靠地监测NAFLD。