Remote Intravascular Pressure Sensing using Ultrasound

使用超声波进行远程血管内压力传感

基本信息

批准号：
10648240
负责人：
Kenneth Hoyt
金额：
$ 18.66万
依托单位：
UNIVERSITY OF TEXAS DALLAS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10648240
关键词：
Animal Model Ascites Blood Pressure Blood Vessels Blood flow Calibration Catheters Cirrhosis Clinical Complication Computer software Contrast Media Creativeness Custom Data Detection Development Diagnosis Ensure Esophageal Varix Exhibits Feedback Frequencies Gases Generations Goals Hepatic Hepatic Encephalopathy Hepatorenal Syndrome Human body Hydrostatic Pressure Imaging Techniques Liquid substance Liver Liver Cirrhosis Liver diseases Maps Measurement Measures Methods Microbubbles Monitor Morbidity - disease rate Patient Care Patients Phase Transition Physical condensation Physiologic pulse Portal Hypertension Positioning Attribute Procedures Process Production Protocols documentation Research Research Project Grants Risk Reduction Signal Transduction Software Engineering System Techniques Technology Time Tissues Transducers Ultrasonic Therapy Ultrasonography Vascularization Venous Pressure level Visualization attenuation clinical translation clinically significant contrast enhanced cost design experience hepatic vein image reconstruction imaging modality imaging system improved in vitro testing in vivo in vivo evaluation innovation innovative technologies mortality nanoDroplet next generation novel phase change pressure sensor technology success transmission process ultrasound

项目摘要

PROJECT SUMMARY Many of the clinically significant complications of liver cirrhosis arise as a consequence of increased portal hypertension. Direct measurement of portal venous pressures is invasive and requires significant procedural experience. Therefore, an accurate and noninvasive method for measurement of portal venous pressure has the potential to reduce risk and enable clinicians to improve the routine workup of patients with liver disease. To that end, our group has exciting data that suggests remote pressure sensing in tissue can be performed using a novel contrast agent and custom technology we have termed tissue intravascular pressure estimation using ultrasound (TIPE-US). A recent advance was in the development of a phase-change contrast agent (PCCA), which is a stabilized liquid nanodroplet under ambient conditions but can be selectively activated using pulsed ultrasound energy to undergo a phase transition into a highly echogenic microbubble detectable using ultrasound imaging. Several studies by our group have consistently shown that the ultrasound energy required for PCCA activation is highly linear and dependent on the hydrostatic pressure of the surrounding fluid. Therefore, we hypothesize that these PCCAs and real-time ultrasound imaging techniques can be used for remote intravascular pressure sensing and detection of portal hypertension. The overarching goal of the proposed research project is to develop a next-generation TIPE-US imaging system and method for remote pressure sensing in vascularized tissue. The first aim of this project is to implement new TIPE-US functionality and feedback control on a programmable ultrasound scanner. In the second aim, we will evaluate the use of custom and monodisperse PCCAs to maximize sensing signal generation and quantification during TIPE-US imaging. We will also conduct the first in vivo tests of TIPE-US using an established animal model portal hypertension.

项目摘要由于门户的增加，肝硬化的许多临床显着并发症发生高血压。直接测量门户静脉压力是侵入性的，需要大量的程序性经验。因此，一种测量门户静脉压力的精确且无创的方法具有降低风险并使临床医生能够改善肝病患者的常规工作的潜力。为此最后，我们的小组有令人兴奋的数据，表明可以使用A进行远程压力感测新颖的对比剂和自定义技术，我们称使用组织内血管内压估计超声（tipe-us）。最近的进步是开发相变造影剂（PCCA），这是在环境条件下稳定的液体纳米圆形，但可以使用脉冲选择性地激活超声能量以使用超声检测到高度回声微泡的相过渡到高度回声成像。我们小组的几项研究一直表明PCCA所需的超声波能量激活是高度线性的，取决于周围流体的静压。因此，我们假设这些PCCA和实时超声成像技术可用于远程血管内静脉高压的压力感应和检测。拟议的研究项目的总体目标是开发下一代tipe-us成像系统和用于血管中远程压力传感的方法组织。该项目的第一个目的是在可编程超声扫描仪。在第二个目标中，我们将评估自定义和单分散的使用 PCCA在tipe-us成像过程中最大化感应信号的产生和定量。我们还将进行使用已建立的动物模型门户高血压的tipe-us的首次体内测试。