23/24 Healthy Brain and Child Development National Consortium

23/24 健康大脑和儿童发展国家联盟

• 批准号: 10748634
• 负责人: RYAN H BOGDAN
• 金额: $ 28.52万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10748634
• 关键词: 10 year old; Address; Administrative Supplement; Affect; Alcohols; Behavioral; Biological; Biology; Birth; Brain; Cannabis; Caregivers; Child; Child Development; Child Health; Childhood; Cognition; Collection; Communities; Complement; Complex; Contracts; Data Collection; Data Coordinating Center; Data Set; Detection; Development; Education; Electroencephalography; Enrollment; Environment; Environmental Exposure; Environmental Hazards; Epigenetic Process; Ethnic Origin; Etiology; Evaluation; Exposure to; Family; Fetus; Funding; Future; Generations; Genes; Genetic; Goals; Health; Health Sciences; Heavy Metals; Image; Immune; Individual; Infant; Infant Health; Knowledge; Leadership; Life; Link; Location; Longitudinal Studies; Magnetic Resonance Imaging; Marijuana; Maternal Health; Measures; Methods; Monitor; Mothers; National Institute of Drug Abuse; Neonatal; Neonatal Abstinence Syndrome; New Mexico; Opioid; Oregon; Outcome; Parents; Participant; Pathogenicity; Physiological; Placenta; Policies; Population; Positioning Attribute; Predisposition; Pregnancy; Pregnant Women; Prenatal care; Prevention; Procedures; Process; Proteins; Protocols documentation; Psychopathology; Public Policy; Race; Research; Resources; Sampling; Shapes; Signaling Protein; Site; Specimen; Stress; Structural Racism; Time Study; Tissue Banks; Tissues; Tobacco; Toxicant exposure; Trauma; Umbilical Cord Blood; Umbilical cord structure; United States; Universities; Washington; Woman; Work; adverse outcome; alcohol consumption during pregnancy; cohort; data acquisition; early experience; experience; fetal; fetal opioid exposure; fetal substance exposure; hazard; improved; in utero; innovation; insight; interest; mRNA Expression; maltreatment; marijuana user; maternal opioid use; multidimensional data; multimodality; neurodevelopment; neuroimaging; novel; nutrition; opioid use; opioid use disorder; opioid use in pregnancy; postnatal; pregnant; prenatal; prenatal exposure; psychologic; racism; response; social; socioeconomics; substance use; success; tool; toxicant

Project Summary/Abstract Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the Healthy Brain and Child Development National Consortium (HBCD-NC) has been formed to deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at 24 sites across the United States (US). The HBCD-NC will carry out a common research protocol under direction of the HBCD-NC Administrative Core (HCAC) and will assemble and distribute a comprehensive and well-curated research dataset to the scientific community at large under the direction of the HBCD-NC Data Coordinating Center (HDCC). The overarching goal of the HBCD-NC is to create a comprehensive, harmonized, and high- dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the sample of women enrolled will include: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant woman with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. In addition, the HBCD-NC will identify key developmental windows during which both harmful and protective environments have the most influence on later neurodevelopmental outcomes. The large, multi-modal, longitudinal, and generalizable dataset that will be produced for the first time by this study will provide novel insights into child development using state- of-the-art methods. The HBCD-NC study will inform public policy to improve the health and development of children across the nation.

项目摘要/摘要 神经发育过程是通过基因和环境之间的动态相互作用来塑造的。 生命早期适应不良的经历会改变发展轨迹，导致有害和持久 发育后遗症。产后和产后危害包括孕产妇的暴露，有毒物质暴露 在怀孕和早期生活，母性健康状况，父母的心理病理学，虐待，结构性 种族主义和过度压力。为了阐明各种环境危害如何影响儿童的发展，这是 必须在生命的头十年中建立发展轨迹的规范模板 基于美国人口中足够大的人口统计学样本。为此， 健康的大脑和儿童发展国家财团（HBCD-NC）已成立以部署 统一，优化和创新的神经影像学（MRI，EEG）的测量值 大量的行为，生理和心理工具以及生物测量要了解 在整个联合的24个地点招收的7,500名母亲和婴儿样本中的神经发育轨迹 国家（美国）。 HBCD-NC将在HBCD-NC的指导下执行共同的研究方案 行政核心（HCAC），并将组装和分发一项全面且精心策划的研究 在HBCD-NC数据协调中心的指导下，向科学界的数据集 （HDCC）。 HBCD-NC的总体目标是创建一个全面，统一和高的目标 维度数据集将表征美国儿童中典型的神经发育轨迹 评估生物学和环境暴露如何影响这些轨迹。将放置特别的重点 关于了解阿片类药物前和产后接触的影响，大麻，酒精，烟草和/或其他 物质。为了解决这些广泛的目标，入学的妇女样本将包括：1）种族， 在种族上和社会经济多样性的队列中，代表了美国人口； 2）孕妇 使用靶向物质（阿片类药物，大麻，酒精，烟草）； 3）在人口统计和行为上 类似的妇女在怀孕中没有药物使用，以实现有效的因果推论。此外，HBCD-NC 将确定有害环境和保护性环境最多的关键发展窗口 对后来神经发育结果的影响。大型，多模式，纵向和可推广的数据集 这项研究将首次生产这将提供对儿童发展的新见解 - 艺术方法。 HBCD-NC研究将告知公共政策，以改善 全国各地的孩子。