Intergenerational Transmission of Stress: Psychosocial and Biological Mechanisms

压力的代际传递：心理社会和生物机制

基本信息

批准号：
10318114
负责人：
RYAN H BOGDAN
金额：
$ 59.88万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-15 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10318114
关键词：
African American Animal Experimentation Attenuated Behavior Biological Biological Assay Biological Factors Biological Markers Black Populations Black race Blood C-reactive protein Characteristics Child Child Abuse and Neglect Child Rearing Coupled Data Dexamethasone Discrimination Elderly Endotoxins Enrollment Exposure to Fasting Funding Generations Health Health behavior Heart Diseases Hormones Hydrocortisone Impulsivity Inflammation Inflammatory Interleukin-6 Knowledge Length Life Stress Longitudinal Studies Maintenance Measures Mental Depression Mental Health Mus Obesity Outcome Pathway interactions Patient Self-Report Personality Policies Prevention Preventive healthcare Psychosocial Factor Psychosocial Stress Public Policy Questionnaires Risk Risk Factors Role Saliva Sampling Signal Transduction Socioeconomic Status Stress Stressful Event Symptoms TNF gene Testing Triad Acrylic Resin United States National Institutes of Health Visit aged antagonist base childhood adversity distrust emotion dysregulation experience grandchild grandparent health care service utilization health disparity health outcome disparity inflammatory marker intergenerational man peer coaching physical conditioning physical symptom protective effect psychological symptom psychosocial racial diversity racial health disparity recruit social integration stress reactivity stressor telomere theories transmission process traumatic event

项目摘要

PROJECT SUMMARY/ABSTRACT Despite growing evidence that health outcomes are perpetuated across generations, empirical examinations of putative mechanisms underlying this intergenerational transmission are lacking. Explanatory mechanisms often focus on stress, which manifests in both psychological and physical symptoms. Relevant pathways have primarily been tested within a single generation or in non-human animal research. From mouse to man, evidence suggests that interplay across stress-related biological (e.g., cortisol, inflammation, telomeres) and psychosocial (e.g., social integration, health behaviors) factors critically contribute to the intergenerational transmission of health. The proposed study will examine the psychosocial ad biological mechanisms through which adversity transmits adverse mental and physical health outcomes across 3 generations and promotes the maintenance of health disparities. To this end, we will leverage a large (G1, n=1,630) and diverse (33% African-American) sample of older adults (currently aged 64-73) enrolled in an ongoing NIH-funded longitudinal study of stress and health and recruit their children (G2, n=2,200) and grandchildren (G3, n=1,900) to complete self-report questionnaires assessing stress, psychosocial factors, and health. From these, a subsample of 300 (150 Black and 150 White) G1/G2/G3 triads (total N=900) will visit our lab to provide blood and saliva measures so that we may assay the stress hormone cortisol, as well as inflammation markers. We will assay both their basal function and evoked activity. Triads and dyads will return to the lab 2.5 years later for a repeat assessment. All measures will be integrated with existing G1 data from our ongoing longitudinal samples. Investigating the intergenerational transmission of stress-related psychosocial and biological factors promises to inform our understanding of how health outcomes and racial health disparities are perpetuated across generations and, may, ultimately guide targeted prevention and public policy.

项目概要/摘要尽管越来越多的证据表明健康结果会代代相传，但实证检验缺乏这种代际传播背后的假定机制。解释机制经常关注压力，压力表现为心理和身体症状。相关途径有主要在一代人或非人类动物研究中进行了测试。从老鼠到人，有证据表明，与压力相关的生物（例如皮质醇、炎症、端粒）和社会心理（例如社会融合、健康行为）因素对代际影响至关重要传递健康。拟议的研究将通过以下方式检查社会心理广告的生物机制：哪种逆境会将不良的心理和身体健康结果传递给 3 代人并促进维持健康差异。为此，我们将利用大量（G1，n=1,630）和多样化（33% 参加 NIH 资助的一项正在进行的非裔美国人）老年人样本（目前年龄 64-73 岁）压力和健康的纵向研究并招募他们的孩子（G2，n = 2,200）和孙子（G3， n=1,900）完成评估压力、心理社会因素和健康的自我报告问卷。从其中，300 个（150 个黑色和 150 个白色）G1/G2/G3 三元组（总 N=900）的子样本将访问我们的实验室提供血液和唾液测量，以便我们可以检测应激激素皮质醇以及炎症标记。我们将测定它们的基础功能和诱发活动。三人组和二人组将返回实验室 2.5年后再次评估。所有措施都将与我们正在进行的现有 G1 数据集成纵向样品。调查与压力相关的社会心理和压力的代际传递生物因素有望帮助我们了解健康结果和种族健康差异这些观念会代代相传，并可能最终指导有针对性的预防和公共政策。