Intergenerational Transmission of Stress: Psychosocial and Biological Mechanisms

压力的代际传递：心理社会和生物机制

基本信息

批准号：
10318114
负责人：
RYAN H BOGDAN
金额：
$ 59.88万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-15 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10318114
关键词：
African American Animal Experimentation Attenuated Behavior Biological Biological Assay Biological Factors Biological Markers Black Populations Black race Blood C-reactive protein Characteristics Child Child Abuse and Neglect Child Rearing Coupled Data Dexamethasone Discrimination Elderly Endotoxins Enrollment Exposure to Fasting Funding Generations Health Health behavior Heart Diseases Hormones Hydrocortisone Impulsivity Inflammation Inflammatory Interleukin-6 Knowledge Length Life Stress Longitudinal Studies Maintenance Measures Mental Depression Mental Health Mus Obesity Outcome Pathway interactions Patient Self-Report Personality Policies Prevention Preventive healthcare Psychosocial Factor Psychosocial Stress Public Policy Questionnaires Risk Risk Factors Role Saliva Sampling Signal Transduction Socioeconomic Status Stress Stressful Event Symptoms TNF gene Testing Triad Acrylic Resin United States National Institutes of Health Visit aged antagonist base childhood adversity distrust emotion dysregulation experience grandchild grandparent health care service utilization health disparity health outcome disparity inflammatory marker intergenerational man peer coaching physical conditioning physical symptom protective effect psychological symptom psychosocial racial diversity racial health disparity recruit social integration stress reactivity stressor telomere theories transmission process traumatic event

African American Animal Experimentation Attenuated Behavior Biological Biological Assay Biological Factors Biological Markers Black Populations Black race Blood C-reactive protein Characteristics Child Child Abuse and Neglect Child Rearing Coupled Data Dexamethasone Discrimination Elderly Endotoxins Enrollment Exposure to Fasting Funding Generations Health Health behavior Heart Diseases Hormones Hydrocortisone Impulsivity Inflammation Inflammatory Interleukin-6 Knowledge Length Life Stress Longitudinal Studies Maintenance Measures Mental Depression Mental Health Mus Obesity Outcome Pathway interactions Patient Self-Report Personality Policies Prevention Preventive healthcare Psychosocial Factor Psychosocial Stress Public Policy Questionnaires Risk Risk Factors Role Saliva Sampling Signal Transduction Socioeconomic Status Stress Stressful Event Symptoms TNF gene Testing Triad Acrylic Resin United States National Institutes of Health Visit aged antagonist base childhood adversity distrust emotion dysregulation experience grandchild grandparent health care service utilization health disparity health outcome disparity inflammatory marker intergenerational man peer coaching physical conditioning physical symptom protective effect psychological symptom psychosocial racial diversity racial health disparity recruit social integration stress reactivity stressor telomere theories transmission process traumatic event

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项目摘要

PROJECT SUMMARY/ABSTRACT Despite growing evidence that health outcomes are perpetuated across generations, empirical examinations of putative mechanisms underlying this intergenerational transmission are lacking. Explanatory mechanisms often focus on stress, which manifests in both psychological and physical symptoms. Relevant pathways have primarily been tested within a single generation or in non-human animal research. From mouse to man, evidence suggests that interplay across stress-related biological (e.g., cortisol, inflammation, telomeres) and psychosocial (e.g., social integration, health behaviors) factors critically contribute to the intergenerational transmission of health. The proposed study will examine the psychosocial ad biological mechanisms through which adversity transmits adverse mental and physical health outcomes across 3 generations and promotes the maintenance of health disparities. To this end, we will leverage a large (G1, n=1,630) and diverse (33% African-American) sample of older adults (currently aged 64-73) enrolled in an ongoing NIH-funded longitudinal study of stress and health and recruit their children (G2, n=2,200) and grandchildren (G3, n=1,900) to complete self-report questionnaires assessing stress, psychosocial factors, and health. From these, a subsample of 300 (150 Black and 150 White) G1/G2/G3 triads (total N=900) will visit our lab to provide blood and saliva measures so that we may assay the stress hormone cortisol, as well as inflammation markers. We will assay both their basal function and evoked activity. Triads and dyads will return to the lab 2.5 years later for a repeat assessment. All measures will be integrated with existing G1 data from our ongoing longitudinal samples. Investigating the intergenerational transmission of stress-related psychosocial and biological factors promises to inform our understanding of how health outcomes and racial health disparities are perpetuated across generations and, may, ultimately guide targeted prevention and public policy.

项目摘要/摘要尽管有越来越多的证据表明健康结果在几代人中持续了下来，但经验考试缺乏这种代际传播的推定机制。解释机制通常专注于压力，这表现在心理和身体症状中。相关途径主要是在单代或非人类动物研究中进行的。从鼠标到人，有证据表明，跨压力相关的生物学（例如皮质醇，炎症，端粒）和社会心理（例如，社会融合，健康行为）因素因代际贡献健康传播。拟议的研究将通过哪些逆境传播了3代的不利身心健康成果，并促进维持健康差异。为此，我们将利用大型（G1，n = 1,630）和多样化（33％非洲裔美国人）的老年人样本（目前64-73岁）被纳入正在进行的NIH资助压力和健康的纵向研究并招募孩子（G2，n = 2,200）和孙子（G3，G3， n = 1,900）完成评估压力，社会心理因素和健康的自我报告问卷。从这些是300（150黑色和150个白色）的子样本G1/G2/G3 Triad（总n = 900）将访问我们的实验室提供血液和唾液措施，以便我们可以分析压力激素皮质醇以及炎症标记。我们将分析它们的基础功能和诱发活性。三合会和二元组将返回实验室 2。5年后进行重复评估。所有措施将与我们正在进行的现有G1数据集成纵向样品。研究与压力相关的心理社会和生物因素有望告知我们对健康结果和种族健康差异的理解在几代人之间存在永久性，并最终指导有针对性的预防和公共政策。