Brain Mechanisms Underlying Plasticity in the Specialization of Cognitive Systems through the Adolescent Period

青春期认知系统专业化可塑性背后的大脑机制

基本信息

批准号：
9900194
负责人：
BEATRIZ LUNA
金额：
$ 14.45万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9900194
关键词：
10 year old 11 year old 12 year old Address Administrative Supplement Adolescence Adolescent Adolescent Development Age Age-Years Animal Model Area Autopsy Biological Biological Assay Biological Markers Brain Cognition Collaborations Data Data Analyses Development Dopamine Estradiol Faculty Female Glutamates Gonadal Steroid Hormones Grant Hair Hormonal Hormones Human Impairment Insula of Reil Lateral Lead Link Longitudinal cohort Measurement Measures Medial Mental disorders Modeling Mood Disorders Neurocognitive Neuronal Plasticity Neurotransmitters Parents Participant Patient Self-Report Population Positioning Attribute Prefrontal Cortex Process Progesterone Protocols documentation Psychopathology Puberty Role Sampling Scanning Schizophrenia Self Assessment Slice Structure Testing Testosterone Thalamic structure Time addiction age related analysis pipeline association cortex boys cingulate cortex cognitive development cognitive system cohort comparison group computerized data processing critical period data acquisition dehydroepiandrosterone gamma-Aminobutyric Acid girls glutamatergic signaling imaging approach improved in vivo indexing innovation male neuromechanism novel parent grant pubertal timing sex spectroscopic imaging success

10 year old 11 year old 12 year old Address Administrative Supplement Adolescence Adolescent Adolescent Development Age Age-Years Animal Model Area Autopsy Biological Biological Assay Biological Markers Brain Cognition Collaborations Data Data Analyses Development Dopamine Estradiol Faculty Female Glutamates Gonadal Steroid Hormones Grant Hair Hormonal Hormones Human Impairment Insula of Reil Lateral Lead Link Longitudinal cohort Measurement Measures Medial Mental disorders Modeling Mood Disorders Neurocognitive Neuronal Plasticity Neurotransmitters Parents Participant Patient Self-Report Population Positioning Attribute Prefrontal Cortex Process Progesterone Protocols documentation Psychopathology Puberty Role Sampling Scanning Schizophrenia Self Assessment Slice Structure Testing Testosterone Thalamic structure Time addiction age related analysis pipeline association cortex boys cingulate cortex cognitive development cognitive system cohort comparison group computerized data processing critical period data acquisition dehydroepiandrosterone gamma-Aminobutyric Acid girls glutamatergic signaling imaging approach improved in vivo indexing innovation male neuromechanism novel parent grant pubertal timing sex spectroscopic imaging success

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项目摘要

Project Summary/Abstract This is an administrative supplement requesting support for significantly enhancing the ability for our parent R01 project to characterize adolescent developmental changes in key neurotransmitters (NT): gamma- Aminobutyric acid (GABA), glutamate (Glu), and dopamine (DA) in their known role in critical period plasticity in prefrontal and associated regions. In our effort to focus on the adolescent period, the age range of the parent grant was 12-30 years of age. Reviewers, though highly enthusiastic, collectively pointed to a missed opportunity to delineate the course of puberty by including younger subjects. This is of particular importance given animal models linking puberty to critical period plasticity in prefrontal cortex. Thus, we are requesting support to (Aim 1) add 24 10-11 year olds and to include (Aim 2) a biological assay of pubertal development given that we presently only have self-report scales limiting our ability to assess pubertal effects on brain development. The addition of younger subjects and a biological assay of puberty will significantly enhance our ability to characterize for the first time in vivo in humans, relevant neurotransmitter changes underlying critical period plasticity of association cortex. Together, these findings have the potential to reveal neural mechanisms of normative plasticity during the period of adolescent development needed to discern processes underlying the emergence of impaired development that can lead to the emergence of major psychopathology (e.g., schizophrenia, mood disorders, addiction) at this time of development.

项目摘要/摘要这是一种行政补充，要求支持大大增强我们父母的能力 R01项目以表征关键神经递质（NT）的青少年发育变化：γ- 氨基丁酸（GABA），谷氨酸（GLU）和多巴胺（DA）在其在关键时期可塑性中的已知作用前额叶和相关区域。在我们专注于青少年时期的努力中，父母的年龄范围格兰特（Grant）年龄12-30岁。评论者虽然非常热情，但他集体指出了错过的通过包括年轻学科来描述青春期的机会。这很重要给定将青春期与前额叶皮质中关键时期可塑性联系起来的动物模型。因此，我们要求支持（AIM 1）添加24 10-11岁的年轻人，并包括（AIM 2）青春期开发的生物学测定法鉴于我们目前只有自我报告量表限制了我们评估对大脑青春期影响的能力发展。添加年轻受试者和青春期生物学测定将显着增强我们的在人类体内首次表征的能力，相关的神经递质的变化是关键的结合皮层的周期可塑性。这些发现在一起有可能揭示神经机制在识别基础过程所需的青少年发展期间的规范性可塑性发展受损的出现，可能导致主要的心理病理学的出现（例如，精神分裂症，情绪障碍，成瘾）在此期间。