US-Nigerian Cancer Control Center for Research on Implementation Science and Equity (C3-RISE)

美国-尼日利亚癌症控制实施科学与公平研究中心 (C3-RISE)

• 批准号: 10738439
• 负责人: OLIVER CHUKWUJEKWU EZECHI
• 金额: $ 104.59万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10738439
• 关键词: Acceleration; Address; Adoption; Affect; Africa; Apical; Applications Grants; Attention; Award; Birth; Cancer Burden; Cancer Control; Cancer Vaccines; Cessation of life; Consolidated Framework for Implementation Research; Country; Coupled; Decentralization; Dose; Educational Activities; Environment; Equity; Evaluation; Evidence based intervention; Faculty; Goals; Grant; Guidelines; Health; Hepatitis B; Hepatitis B Vaccination; Hepatitis B Vaccines; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Incidence; Infrastructure; Institution; Intervention; Learning; Malignant Neoplasms; Malignant Vaginal Neoplasm; Malignant neoplasm of cervix uteri; Malignant neoplasm of liver; Malignant neoplasm of penis; Malignant neoplasm of vulva; Medical Research; Mentors; Mentorship; Mission; Modeling; Monitor; National Institute of Mental Health; Newborn Infant; Nigeria; Nigerian; North Carolina; Phase; Policies; Principal Investigator; Process; Productivity; Research; Research Personnel; Research Project Grants; Resource-limited setting; Resources; Science; Services; Students; System; Testing; Training; Training Programs; Translations; Travel; United States National Institutes of Health; Universities; Vaccination; Vaccines; Vision; aged; anticancer research; apprenticeship; cancer prevention; career; community based participatory research; community engagement; community setting; crowdsourcing; design; direct application; evidence base; girls; health equity; health inequalities; implementation evaluation; implementation facilitators; implementation outcomes; implementation science; implementation strategy; improved; innovation; low and middle-income countries; malignant mouth neoplasm; mortality; multidisciplinary; novel; outreach; prevent; public health relevance; research and development; research study; scale up; skills; success; symposium; tool; uptake; vaccine acceptance; Acceleration; Address; Adoption; Affect; Africa; Apical; Applications Grants; Attention; Award; Birth; Cancer Burden; Cancer Control; Cancer Vaccines; Cessation of life; Consolidated Framework for Implementation Research; Country; Coupled; Decentralization; Dose; Educational Activities; Environment; Equity; Evaluation; Evidence based intervention; Faculty; Goals; Grant; Guidelines; Health; Hepatitis B; Hepatitis B Vaccination; Hepatitis B Vaccines; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Incidence; Infrastructure; Institution; Intervention; Learning; Malignant Neoplasms; Malignant Vaginal Neoplasm; Malignant neoplasm of cervix uteri; Malignant neoplasm of liver; Malignant neoplasm of penis; Malignant neoplasm of vulva; Medical Research; Mentors; Mentorship; Mission; Modeling; Monitor; National Institute of Mental Health; Newborn Infant; Nigeria; Nigerian; North Carolina; Phase; Policies; Principal Investigator; Process; Productivity; Research; Research Personnel; Research Project Grants; Resource-limited setting; Resources; Science; Services; Students; System; Testing; Training; Training Programs; Translations; Travel; United States National Institutes of Health; Universities; Vaccination; Vaccines; Vision; aged; anticancer research; apprenticeship; cancer prevention; career; community based participatory research; community engagement; community setting; crowdsourcing; design; direct application; evidence base; girls; health equity; health inequalities; implementation evaluation; implementation facilitators; implementation outcomes; implementation science; implementation strategy; improved; innovation; low and middle-income countries; malignant mouth neoplasm; mortality; multidisciplinary; novel; outreach; prevent; public health relevance; research and development; research study; scale up; skills; success; symposium; tool; uptake; vaccine acceptance

ABSTRACT Nigeria has a substantial number of preventable cancer deaths each year. The human papillomavirus (HPV) vaccine and hepatitis B (HBV) vaccine are both evidence-based strategies to prevent cancer, but they have not been widely scaled up in Nigeria. This suggests the need for innovative strategies that leverage implementation science and tap the collective wisdom of Nigeria, Africa’s most populous country. We propose the “US-Nigerian Cancer Control Center for Research on Implementation Science and Equity (C3-RISE).” Our overall mission is two part: (a) use participatory implementation science strategies (i.e. crowdsourcing open calls and apprenticeships) to expand uptake of HPV and HBV vaccines for cancer prevention; and (b) serve as a hub for equity and capacity building in implementation science to advance the understanding of intervention uptake and sustainment of evidence-based interventions to prevent cancer. This project brings together an exceptional group of multi-disciplinary researchers from the Nigerian Institute of Medical Research (the apex federal health research organization, similar to the US NIH), St. Louis University, and the University of North Carolina at Chapel Hill. We propose the following aims: (1) To accelerate equitable cancer control by developing, testing, and refining participatory implementation strategies to decentralize vaccines to prevent cancer in community settings; (2) To enhance the scientific productivity of C3-RISE by providing overarching operational and scientific oversight; (3) To support innovative research and the development of scholars trained to accelerate the uptake and sustainment of evidence-based cancer control interventions in Nigeria. These aims will be accomplished by a nurturing hub of two cores (Administrative, Capacity Building) alongside two research studies (Study 1 focused on HPV vaccination, Study 2 on HBV vaccination). Our three partner institutions launched a participatory implementation science project four years ago that directly informed national Nigerian health guidelines, trained 231 students, provided mentorship opportunities to 43 faculty, and culminated in a WHO/TDR practical guide on crowdsourcing for health (UH3HD096929). This led to a recently awarded NCI R01 grant (R01-CA271033) that uses participatory implementation science to develop innovative strategies to enhance HPV services in Nigeria. C3-RISE will leverage this momentum to catalyze cutting-edge cancer research, training, community engagement, and policy translation. Our project will increase health equity, and it aligns with the Nigerian National Cancer Control Plan by focusing on participation, capacity building, and sustainment. This U54 grant application directly responds to NIH, NCI, and NIMH strategic priorities.

抽象的 尼日利亚每年有大量可预防的癌症死亡。人乳头瘤病毒（HPV） 疫苗和丙型肝炎（HBV）疫苗都是预防癌症的循证策略，但尚未 在尼日利亚广泛规模。这表明需要利用创新策略 实施科学并利用非洲人口最多的国家尼日利亚的集体智慧。我们建议 “实施科学与权益研究研究中心（C3阶层）”。我们的 总体任务是两个部分：（a）使用参与实施科学策略（即众包公开 呼叫和学徒制）扩大了HPV和HBV疫苗的吸收，以预防癌症； （b）作为 实施科学中公平和能力建设的枢纽，以提高对干预的理解 采取和维持基于证据的干预措施以预防癌症。这个项目汇集了一个 尼日利亚医学研究所（APEX）的多学科研究人员的杰出组 联邦卫生研究组织，类似于美国国民党），圣路易斯大学和北大学 卡罗来纳州教堂山。我们提出以下目的：（1）通过 制定，测试和完善参与实施策略，使疫苗分散以防止 在社区环境中的癌症； （2）通过提供总体来提高C3-Rise的科学生产率 运营和科学监督； （3）支持创新研究和学者的发展 经过培训，可以加快尼日利亚循证癌症控制干预措施的吸收和维持。 这些目标将通过两个核心的枢纽（行政，能力建设）以及 两项研究（研究1侧重于HPV疫苗接种，研究2 HBV疫苗接种）。我们的三个伙伴 四年前，机构启动了一个参与实施科学项目，该项目直接告知 尼日利亚国家卫生指南，培训了231名学生，为43位教职员工提供了精明的机会， 在WHO/TDR众包健康的实用指南中达到高潮（UHDHD096929）。这导致了最近 授予使用参与实施科学发展创新的NCI R01赠款（R01-CA271033） 增强尼日利亚HPV服务的策略。 C3-Rise将利用这一势头来催化前沿 癌症研究，培训，社区参与和政策翻译。我们的项目将增加健康 公平性，并通过专注于参与，能力来与尼日利亚国家癌症控制计划保持一致 建造和维持。该U54赠款申请直接响应NIH，NCI和NIMH策略 优先事项。