Actions for Collaborative Community Engaged Strategies for HPV (ACCESS HPV)

HPV 社区参与协作策略行动 (ACCESS HPV)

• 批准号: 10708926
• 负责人: OLIVER CHUKWUJEKWU EZECHI
• 金额: --
• 依托单位: SAINT LOUIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2023-09-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10708926
• 关键词: AIDS prevention; Address; African; Age; Applications Grants; Area; Cancer Burden; Cancer Control; Cancerous; Caregivers; Cervical Cancer Screening; Clinic; Collection; Communities; Community Health Aides; Community Participation; Country; Daughter; Development; Dissemination and Implementation; Dose; Economic Models; Elements; Female; Goals; Government; Group Structure; HIV; Health Services Accessibility; Human Papilloma Virus Vaccination; Human Papillomavirus; Human papillomavirus 6; Immunization Programs; Individual; Interdisciplinary Study; Intervention; Knowledge; Laboratories; Learning; Lesion; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Medical Research; Methods; Modeling; Morbidity - disease rate; Mothers; National Cancer Institute; Nigeria; Nigerian; Participant; Population; Prevention; Prevention strategy; Preventive measure; Primary Prevention; Problem Solving; Proctor framework; Quality-Adjusted Life Years; Randomized, Controlled Trials; Recommendation; Records; Research; Research Infrastructure; Resource-limited setting; Risk; Sampling; Secondary Prevention; Services; Specimen; State Government; Strategic Planning; Techniques; Time; United States; United States National Institutes of Health; Vaccination; Woman; Work; Youth; anticancer research; cancer prevention; cancer vaccination; community based participatory research; community clinic; community engagement; cost effectiveness; crowdsourcing; design; direct application; dissemination science; effectiveness evaluation; experience; experimental study; girls; health communication; implementation evaluation; implementation outcomes; implementation process; implementation research; implementation science; implementation strategy; improved; learning community; low and middle-income countries; mortality; mother-daughter relationship; older women; preference; premalignant; prevention service; primary outcome; programs; public health relevance; recruit; risk perception; scale up; screening; screening program; secondary outcome; self testing; social cognitive theory; treatment as usual; uptake; vaccine acceptance

ABSTRACT Cervical cancer is a major cause of morbidity and mortality in many sub-Saharan countries, including Nigeria. Expanding human papillomavirus (HPV) vaccination for young girls/women, ages 9-26 years (primary prevention) and HPV self-collection for cervical cancer screening for older women, ages 30-49 (secondary prevention) are both critical to achieving WHO and Nigerian goals for reducing the cervical cancer burden. The Nigerian government now recommends HPV vaccination and self-collection, yet uptake is poor. As such, context-specific, targeted and culturally relevant implementation strategies are needed. We focus on HPV vaccination among girls and self-collection among women because of the substantial burden of cervical cancer. Mother-daughter relationships in Nigeria can be leveraged to increase HPV vaccination uptake among young girls and HPV self-collection among mothers. Mothers (or similar female caregivers) profoundly influence decisions and preferences about young girls’ vaccine uptake in the Nigerian cultural context. At the same time, maternal choices about HPV self-collection can be reinforced in discussions with their daughters. In the proposed study, Actions for Collaborative Community-Engaged Strategies for HPV (ACCESS-HPV), we will use participatory crowdsourcing methods to drive HPV prevention among mother-daughter dyads. Crowdsourcing open calls will allow us to identify locally relevant messages and dissemination techniques to increase uptake of HPV prevention. Then, participatory learning communities will build capacity for community- led implementation of selected strategies. Informed by social learning theory and the PEN-3 cultural model, our multi-disciplinary research team proposes the following specific aims: (1) to develop a new combined campaign to increase HPV vaccination for young girls (ages 9-26) and HPV self-collection for mothers (ages 30-49) using crowdsourcing open calls and participatory learning communities; (2) to determine the effectiveness of a final combined campaign on uptake of HPV vaccination among young girls/women and HPV self-collection among their mothers using a stepped-wedge randomized controlled trial; (3) to estimate the impact and cost-effectiveness of the crowdsourced campaign. Our primary outcome will be vaccine uptake (ascertained by clinic records of vaccine uptake) among young girls and HPV self-collection (ascertained by laboratory receipt of specimens) among their mothers. The strong support of the Nigerian Institute for Medical Research (NIMR) alongside national HPV programs creates a rich research infrastructure and increases the likelihood of successful implementation. Our multi-disciplinary research team has experience organizing implementation research focused on crowdsourcing and community participation in Nigeria. This study will enhance our understanding of HPV prevention in resource-constrained settings. This grant application directly responds to strategic priorities of the United States government, the National Institutes of Health, the National Cancer Institute, and NOT-CA-20-025.

抽象的 宫颈癌是包括尼日利亚在内的许多撒哈拉以南国家发病率和死亡率的主要原因。 扩大9-26岁的年轻女孩/妇女的人类乳头瘤病毒（HPV）疫苗接种（主要 预防）和HPV自我收集，用于老年妇女的宫颈癌筛查，年龄在30-49岁（次级） 预防）对于实现谁和尼日利亚的目标是减少宫颈癌伯恩的目标至关重要。 尼日利亚政府现在建议HPV疫苗接种和自我收集，但吸收却很差。像这样， 需要特定于上下文，有针对性的和具有文化相关的实施策略。我们专注于HPV 女孩之间的疫苗接种和妇女的自我收集，因为宫颈大量燃烧 癌症。可以利用尼日利亚的母女关系，以增加HPV疫苗接种的吸收 年轻女孩和母亲之间的HPV自我收集。母亲（或类似的女性照顾者）深刻 在尼日利亚文化背景下影响对年轻女孩疫苗采用疫苗的决策和偏好。在 同时，可以在与女儿的讨论中加强有关HPV自我收集的选择。在 拟议的研究，针对HPV协作社区参与策略（Access-HPV）的行动，我们将 使用参与攀爬方法来推动母女二元组的HPV预防。 众包打开电话将使我们能够确定本地相关的信息和传播技术 增加预防HPV的吸收。然后，参与学习社区将为社区增强能力 - LED实施选定策略。由社会学习理论和Pen-3文化模型所告知，我们的 多学科研究团队提出以下特定目的：（1）开发新的合并 为增加年轻女孩的HPV疫苗接种（9-26岁）和母亲的HPV自我收集（年龄）的运动（年龄） 30-49）使用众包公开电话和参与学习社区； （2）确定 最终的合并运动对年轻女性/女性HPV疫苗接种的吸收的有效性 他的母亲之间使用阶梯式向外的随机对照试验进行自我收集； （3）估计 众包运动的影响和成本效益。我们的主要结果将是疫苗的吸收 （通过疫苗摄取的诊所记录确定）年轻女孩和HPV自我收集（确定 其母亲中的实验室收到标本。尼日利亚医学研究所的大力支持 研究（NIMR）与国家HPV计划一起创建了丰富的研究基础设施，并增加了 成功实施的可能性。我们的多学科研究团队有组织的经验 实施研究的重点是众包和社区参与尼日利亚。这项研究会 在资源约束设置中增强我们对HPV预防的理解。该赠款申请直接 对美国政府，国立卫生研究院，国家的战略重点的回应 癌症研究所和非CA-20-025。