Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI)

南非的健康、老龄化和痴呆症：纵向研究 (HAALSI)

基本信息

批准号：
10627328
负责人：
LISA F BERKMAN
金额：
$ 479.21万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-15 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10627328
关键词：
Adopted Adult Africa Age Years Aging Alzheimer&apos s Disease Behavioral Biological Biological Factors Biological Markers Cardiometabolic Disease Chronic Disease Clinical assessments Cognition Cohort Studies Collaborations Collection Communities Complex Country Data Data Collection Dementia Development Disabled Persons Disease Economic Factors Economics Elderly Ensure Epidemiology Family Funding Genetic Population Study HIV HIV Infections Health Health Policy Health and Retirement Study Household Impaired cognition Incidence Income Individual Interview Longitudinal Studies Measures Methods Mission Outcome Participant Pattern Personal Satisfaction Persons Physical Function Policies Population Population Dynamics Population Genetics Population Research Prevalence Protocols documentation Public Health Public Policy Research Research Project Grants Rest Risk Factors Rural Rural Community Sampling Security Shapes Sister Social Policies South Africa Structure Surveys System Woman aging population cognitive function cognitive performance cognitive testing cohort dementia risk design experience follow-up healthy aging human old age (65+)improved innovation insight low and middle-income countries member men mortality neuroimaging population health programs recruit resilience response rural South Africa salt intake social social factors social health determinants socioeconomics virtual

项目摘要

Overall—Abstract Adults in South Africa are surviving to older ages, yet the burden and risk factors of aging-related diseases, particularly dementia and Alzheimer’s disease, remains poorly defined. By 2050, more than 75% of global dementia cases are projected to occur in low- and middle-income countries (LMICs). The proposed renewal of the Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI) Program includes four tightly integrated projects supported by three cores that together will reveal interrelationships among common chronic diseases and other risk factors of cognitive impairment and dementia in South Africa. Each project rests on a common platform of individual surveys, cognitive assessments, biomarker collection, and mortality ascertainment, with additional measures specific to each project. In previous funding cycles (2014-2022), we successfully collected three waves of HAALSI Agincourt data in 5059 men and women ≥40 years of age, achieving response rates of 86-94% among living cohort members. We also collected two waves of data under the Harmonized Cognitive Assessment Protocol (HCAP) at 3-year intervals. For this renewal application, the HAALSI Program will continue following the HAALSI Agincourt cohort (Aim 1), including original enrollees and a refresher sample of 1898, 40- to 49-year-olds, for a total of 13 years of longitudinal data. We will conduct a third HCAP wave on a subsample of the HAALSI Agincourt cohort, with expanded biomarker, neuroimaging, and clinical assessments to understand interactions among cognitive impairment/dementia, HIV infection, and cardiometabolic disorders (CMDs). In Aim 2, we will identify biological, social, and economic predictors of mortality and dementia, and assess disease incidence and changes in physical and cognitive function in the HAALSI Agincourt cohort. In addition, in Aim 3, we will pilot and launch a nationally representative cohort study of 4500 people ≥40 years of age and their partners (approximately 7200 total) using approaches from the HAALSI Agincourt survey; of these, approximately 624 will also undergo the HCAP. The HAALSI National survey will enable us to estimate the prevalence of dementia and other aging-related conditions, and their cross-sectional associations with socioeconomic, behavioral, and health utilization exposures. We will use innovative transportability methods to assess the alignment of diseases in the rural Agincourt community with the national level. In Aim 4, we will evaluate the health impacts of public health and social policies developed to improve healthy aging, specifically those aimed at reducing salt intake, and increasing financial security of older adults, families, and individuals with disabilities. Finally, in Aim 5, we will maximize collaborations with HRS sister studies, H3Africa and DS-I Africa projects, enabling cross-country comparisons and studies at the level of population genetics. Together, the HAALSI Program will produce valuable insights into the burden and drivers of dementia and other aging-related diseases in South Africa, which inform the development of effective policies to ensure healthy aging and wellbeing of aging populations.

总体而言 - 取样南非的成年人正在幸存到年龄较大的年龄，但是与衰老有关的疾病的烧伤和危险因素，特别是痴呆症和阿尔茨海默氏病，仍然定义很差。到2050年，超过75％的全球痴呆症病例预计将发生在低收入和中等收入国家（LMIC）。提议的续约南非的健康，衰老和痴呆症：一项纵向研究（Haalsi）计划包括四个由三个核心支持的紧密整合项目将共同揭示共同关系南非认知障碍和痴呆症的慢性疾病和其他危险因素。每个项目基于单个调查，认知评估，生物标志物收集和死亡率的共同平台确定，并采取针对每个项目的其他措施。在以前的资金周期（2014-2022）中，我们成功收集了5059名男女≥40岁的男性和女性的三波Haalsi Agincourt数据在活着的队列成员中，达到86-94％的响应率。我们还在统一的认知评估方案（HCAP）以3年的间隔。对于此续订应用程序， Haalsi计划将继续遵循Haalsi Agincourt队列（AIM 1），包括原始注册和 1898年的复习样本，40至49岁，总共有13年的纵向数据。我们将进行 Haalsi Agincourt队列子样本上的第三hcap波，具有扩展的生物标志物，神经成像，和临床评估，以了解认知障碍/痴呆，艾滋病毒感染和心脏代谢性疾病（CMD）。在AIM 2中，我们将确定生物，社会和经济预测指标死亡率和痴呆，以及评估疾病的事件以及身体和认知功能的变化 Haalsi Agincourt队列。此外，在AIM 3中，我们将试行并启动全国代表性的研究 4500名≥40岁的人，他们的伴侣（总计约7200）使用了 Haalsi Agincourt调查；其中，大约有624个将经历HCAP。 Haalsi国民调查将使我们能够估计痴呆症和其他与衰老有关的疾病的患病率及其与社会经济，行为和健康利用暴露的横断面关联。我们将使用创新的可运输方法评估了粗糙的Agincourt社区中疾病对齐的一致性国家一级。在AIM 4中，我们将评估开发到公共卫生和社会政策的健康影响改善健康的衰老，特别是那些旨在减少盐摄入量的衰老，并提高财务安全老年人，家庭和残疾人。最后，在AIM 5中，我们将最大化与 HRS姐妹研究，H3AFRICA和DS-I非洲项目，在越野比较和研究人口遗传学水平。 Haalsi计划一起将对燃烧和南非痴呆症和其他与衰老有关的疾病的驱动因素，这为有效的发展提供了信息确保衰老人群的健康衰老和福祉的政策。

项目成果

期刊论文数量（58）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Associations between cohort derived dementia and COVID-19 serological diagnosis among older Black adults in rural South Africa.

DOI：
10.3389/fpubh.2023.1304572
发表时间：
2023
期刊：
FRONTIERS IN PUBLIC HEALTH
影响因子：
5.2
作者：
Harriman, Nigel Walsh;Bassil, Darina T.;Farrell, Meagan T.;Du Toit, Jacques;Casas, F. Xavier Gomez-Olive;Tollman, Stephen M.;Berkman, Lisa F.
通讯作者：
Berkman, Lisa F.

Association of alcohol use and multimorbidity among adults aged 40 years and above in rural South Africa.