Health and Aging in Africa: Longitudinal Studies of INDEPTH Communities

非洲的健康与老龄化：INDEPTH 社区的纵向研究

• 批准号: 8734308
• 负责人: LISA F BERKMAN
• 金额: $ 90.95万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8734308
• 关键词: AIDS/HIV problem; Adult; Africa; Africa South of the Sahara; Age; Aging; Algorithms; Area; Autopsy; Baseline Surveys; Behavioral; Cardiovascular Diseases; Cardiovascular system; Censuses; Characteristics; China; Chronic; Chronic Disease; Clinical; Clinical assessments; Cognitive; Communicable Diseases; Communities; Complex; Country; Data; Data Collection; Demographic Transitions; Disease; Economic Conditions; Economics; Elderly; Elements; Epidemiologic Studies; Epidemiology; Event; Expenditure; Family; Ghana; Goals; HIV; Health; Health Policy; Health Transition; Health system; Household; Incidence; Income; India; Intervention; Labor Forces; Longitudinal Studies; Longitudinal Surveys; Monitor; Mortality Decline; Nature; Nomads; Participant; Personal Satisfaction; Physical Function; Policies; Population; Prevalence; Productivity; Resources; Respondent; Rest; Retirement; Risk; Risk Factors; Sampling; Sister; Site; Social Conditions; Social Environment; Social Policies; Source; South Africa; Staging; Surveys; Tanzania; Time; Validity and Reliability; Visit; Woman; aged; base; cognitive function; cohort; disability; disorder risk; evidence base; experience; field study; follow-up; functional decline; functional outcomes; improved; information gathering; interdisciplinary approach; longitudinal analysis; men; mortality; population based; programs; research study; social; trend

DESCRIPTION (provided by the applicant): Over the last decades, countries in Sub-Saharan Africa (SSA) have experienced a demographic and epidemiological transition with declines in mortality from infectious diseases and increases in the prevalence of non-communicable disease. Many adults in SSA are now surviving with chronic diseases whether they are communicable or non-communicable. While we have data resources to understand the challenges of aging in the context of high income countries, little is understood of the nature of aging in the SSA context. Our project aims to establish longitudinal surveys of health, aging, and well-being allowing estimation of the prevalence and incidence of major chronic conditions in 3 population-based health and demographic surveillance sites (HDSS) at different stages of health transitions (in South Africa, Ghana and Tanzania) in adults age 50 and over (n=12,000). Participants are surveyed in each year 2014 to 2017 with continuous mortality monitoring. Baseline surveys are introduced in one country per year, with South Africa in year 2, Ghana in year 3 and Tanzania in year 4. A 3 year follow up occurs in South Africa in year 5. Through intensive monitoring and follow up, migrants will be maintained in the cohort at very high levels. Our survey is comparable to that of the Health and Retirement Study (HRS) and sister surveys, yet is adapted to capture characteristics specific to SSA. With 4 subprojects on 1.physical and cognitive function, 2.cardiometabolic disorders, 3.HIV, and 4.economic well-being, our goal is to understand the determinants of health in the elderly and in turn find the consequences of health for productivity and well-being. Our specific aims are: 1. To establish three cohorts of 4,000 men and women aged 50 and over based on random stratified samples of the HDSS populations in the INDEPTH sites of Agincourt in South Africa, Navrongo in Ghana and Ifakara in Tanzania (n=12,000). A clinical substudy is conducted in a 10% subsample to look intensively at HIV and CVD. 2. To identify social, economic and biologic predictors of mortality, the incidence of disease (particularly cardiovascular disease and HIV) and changes in physical and cognitive function over three years. 3. To identify the effects of ill health on the economic well-being and productivity of the three cohorts. We aim to identify the ways in which behavioral and biologic risks are embedded in the social and policy context and are driven by social and economic conditions. Health policies, in the broadest sense, will need to rest on a strong evidence base and our study will provide valid and reliable assessments of phenotypic disorders and risk factors.

描述（由申请人提供）：在过去的几十年中，撒哈拉以南非洲（SSA）的国家经历了人口统计学和流行病学转变，传染病的死亡率下降，并增加了非可传染病的患病率。 SSA中的许多成年人现在都在慢性疾病中幸存下来，无论他们是传染性的还是不可传播的。尽管我们有数据资源来了解在高收入国家中衰老的挑战，但在SSA背景下衰老的性质几乎没有理解。我们的项目旨在建立对健康，衰老和福祉的纵向调查，允许估计3个基于人群的健康和人口统计学监测地点（HDS）在健康过渡的不同阶段（在南非，加纳，加纳和坦桑尼亚）中的3个基于人群的健康和人口监测地点（HDS）的患病率和发生率。通过持续的死亡率监测，在2014年至2017年每年对参与者进行调查。基准调查是每年一个国家进行的，南非在第2年，加纳在第3年和4年级进行坦桑尼亚。第5年在南非进行了3年的随访。通过密集的监测和跟进，将在同伙中保持移民的水平很高。我们的调查与健康和退休研究（HRS）和姊妹调查相当，但适应于捕获SSA特定的特征。有4个对生理学和认知功能的次要标准，2。金属代谢性疾病，3.HIV和4.经济福祉，我们的目标是了解老年人中健康的决定因素，进而发现健康对生产力和福祉的后果。我们的具体目的是：1。基于南非阿金库特（Agincourt）在阿金库特（Agincourt）内部的HDSS人群的随机分层样本，加纳的加纳（Navrongo）和坦桑尼亚的ifakara，建立30名及50岁及50岁的男女队列（n = 12,000）。在10％的子样本中进行临床典型，以对HIV和CVD进行密切关注。 2。确定死亡率的社会，经济和生物学预测因素，疾病的发病率（尤其是心血管疾病和艾滋病毒）以及三年来身体和认知功能的变化。 3。确定健康状况对三个队列的经济福祉和生产力的影响。我们旨在确定行为和生物学风险嵌入社会和政策环境中的方式，并由社会和经济状况驱动。从广义上讲，健康政策将需要基于强大的证据基础，我们的研究将对表型疾病和危险因素进行有效可靠的评估。