Cognitive Function, Alzheimer's Disease and Related Disorders in the HAALSI Cohort

HAALSI 队列中的认知功能、阿尔茨海默病和相关疾病

• 批准号: 10200613
• 负责人: LISA F BERKMAN
• 金额: $ 100.78万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200613
• 关键词: Affect; Africa; Africa South of the Sahara; Aging; Alleles; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Apolipoprotein E; Binding; Biological; Blood; Blood Glucose; Blood Vessels; Brain; Cerebrovascular Disorders; Cerebrovascular system; China; Clinical; Cognition; Cognitive; Cognitive aging; Collection; Communities; Country; Data Collection; Dementia; Diagnosis; Disease; Elderly; Epidemiology; Etiology; Europe; Event; Family; Frequencies; Future; Genetic; Genetic Risk; Goals; HIV; HIV Infections; Health; Health and Retirement Study; Hypertension; Impaired cognition; Incidence; India; Interview; Longitudinal Studies; Longitudinal cohort; Magnetic Resonance Imaging; Measures; Mediating; Medical; Methods; Mexico; Neurologist; Neuropsychology; Normal Range; Outcome; Participant; Physicians; Population; Population Research; Prevalence; Protocols documentation; Risk; Risk Factors; Schools; Sex Differences; Sister; Site; Social Network; South Africa; South African; Standardization; Structure; Testing; Thick; Vascular Diseases; Venous; Woman; adjudicate; age difference; aged; aging brain; base; childhood adversity; cognitive change; cognitive function; cognitive testing; cohort; dementia risk; experience; falls; follow-up; functional decline; functional outcomes; high risk; hypercholesterolemia; imaging biomarker; informant; literacy; member; men; mild cognitive impairment; neuroimaging marker; novel; polygenic risk score; population based; programs; psychosocial; rural South Africa; screening; social; social engagement; vascular risk factor

ABSTRACT: Cognitive Function, Alzheimer's Disease and Related Disorders (ADRD) in HAALSI The overarching goal of this study is to identify the incidence and prevalence of Alzheimer's Disease and Re- lated Dementias (ADRD) and associated biological and social risk factors in a population-based cohort of South African men and women aged 40 and over (n=5059) living in Agincourt, South Africa. The Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI) has completed its first wave and continues for two additional waves through 2021, providing over 6 years of follow-up. HAALSI was developed as a harmonized sister study to the US Health and Retirement Study (HRS) and other global studies. In 2016, we launched the HAALSI Dementia Study, including all probable cases of dementia within HAALSI, and a subsample of HAALSI participants with normal cognition and mild cognitive impairment (MCI) for more detailed cognitive, clinical, and functional assessments (n= 607). The approach of the currently pro- posed extension of the HAALSI Dementia Study is to field two additional waves of enriched assessments sup- plemented with MRIs to obtain more detailed information on social and biological risk factors for ADRD in the HAALSI cohort. We will add new cases of probable dementia based on cognitive screening in future HAALSI waves to gather longitudinally accurate incidence and prevalence rates over 6 years. AIM 1: Estimate the incidence and prevalence of ADRD and characterize cognitive function and change in the HAALSI cohort. With 6 years of longitudinal information, we have 3 waves of sensitive neuropsycholog- ical measures, clinical and informant assessments, and functional outcomes. We estimate prevalent and inci- dent dementia cases and describe trajectories of cognitive aging, and describe structural markers of brain ag- ing via an MRI substudy. AIM 2: Evaluate biological predictors of incident dementia, cognitive function and decline, and brain aging. We use MRI to measure regional volume, cortical thickness, and markers of small and large vessel cerebrovascular disease. We assess associations between neuroimaging biomarkers, dementia, and cognitive impairment and associations with HIV and vascular disease. Venous blood collection enables us to evaluate known genetic risks for ADRD, such as Apolipoprotein E (APOE)-E4 allele, ATP- binding cassette sub-family A member 7 (ABCA7) and AD polygenic risk scores in this novel population. AIM 3: Evaluate social risks factors for incident dementia and cognitive impairment and decline. We will administer psychosocial measures to examine the extent to which dementia, cognitive decline, and brain func- tion are affected by educational experience, social engagement and networks, and childhood adversity. We will explore mediating relationships between biological and social risk factors on outcomes. Our study makes an important contribution to understanding ADRD, cognition, and brain aging in sub-Saharan Africa where many countries are experiencing rapid demographic and epidemiologic transitions.

摘要：Haalsi的认知功能，阿尔茨海默氏病和相关疾病（ADRD） 这项研究的总体目标是确定阿尔茨海默氏病的发生率和流行率 基于人群 居住在南非阿金库特的40岁及40岁以上的南非男女。健康和 非洲的衰老：对南非一个深入社区（Haalsi）的纵向研究已完成 在2021年之前，第一波继续进行了两波，提供了超过6年的随访。海尔斯 是作为一项协调的姐妹研究开发的，用于美国健康和退休研究（HRS）和其他全球 研究。 2016年，我们启动了Haalsi痴呆研究，包括所有可能的痴呆病例 Haalsi，以及正常认知和轻度认知障碍的Haalsi参与者的子样本（MCI） 有关更详细的认知，临床和功能评估（n = 607）。当前亲 Haalsi痴呆症研究的扩展是要在两次富集评估的范围 配备MRI，以获取有关ADRD社会和生物学风险因素的更详细信息 Haalsi队列。我们将根据未来Haalsi的认知筛查添加新的可能的痴呆症病例 波浪以在6年内收集纵向准确的发病率和患病率。 目标1：估计ADRD的发病率和流行率并表征认知功能和变化 在Haalsi队列中。有6年的纵向信息，我们有3波敏感的神经心理学波 - ICAL措施，临床和线人评估以及功能结果。我们估计普遍存在 凹陷痴呆病例并描述认知衰老的轨迹，并描述脑Ag-的结构标记 通过MRI典型。目标2：评估入射痴呆，认知功能的生物学预测因子 和衰落和大脑衰老。我们使用MRI测量区域量，皮质厚度和标记 小血管脑血管疾病。我们评估神经影像学生物标志物之间的关联， 痴呆症，以及与艾滋病毒和血管疾病的认知障碍和关联。静脉血收集 使我们能够评估已知的ADRD遗传风险，例如载脂蛋白E（APOE）-e4等位基因，ATP- 在这个新的人群中，结合盒子子家庭成员7（ABCA7）和AD多基因风险评分。目的 3：评估事件痴呆和认知障碍和下降的社会风险因素。我们将 进行心理社会措施，以检查痴呆症，认知能力下降和大脑功能的程度 受教育经验，社会参与和网络以及童年逆境的影响。我们将 探索生物学和社会风险因素与结果之间的中介关系。 我们的研究为了解撒哈拉以南的ADRD，认知和大脑衰老做出了重要贡献 许多国家正在经历快速人口和流行病学转变的非洲。