Viral Pathogenesis Core

病毒发病机制核心

• 批准号: 10621230
• 负责人: Thomas Hope
• 金额: $ 8.05万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-09 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621230
• 关键词: AIDS prevention; Abbreviations; Acquired Immunodeficiency Syndrome; Address; Adherence; Administrative Supplement; Aging; Animal Model; Antibodies; Behavioral; Behavioral Sciences; Biological; Biological Assay; Biological Markers; Biology of Aging; Cell Culture Techniques; Cells; Chicago; Chronic Disease; Clinical; Clinical Sciences; Collaborations; Colon; Complex; Consultations; Continuity of Patient Care; Creativeness; Data; Data Set; Development; Discipline; Disease; Doctor of Philosophy; Engineering; Enzyme-Linked Immunosorbent Assay; Epidemic; Equipment; Experimental Designs; Faculty; Genes; Genetic; Glossary; HIV; Human; Image; Imaging technology; Immunologics; Immunologist; Immunology; Immunology procedure; Infection; Institution; Interdisciplinary Study; Intervention; Journals; Knowledge; Laboratories; Laboratory Scientists; Macaca; Mentorship; Methods; Mission; Molecular; Molecular Biology; Monitor; Pathogenicity; Performance; Persons; Population; Proteomics; Reagent; Research; Research Personnel; Resources; Risk; SIV; Scientist; Services; Structure; Systems Biology; Technology; Tissue Procurements; Tissues; Tonsil; Training; United States National Institutes of Health; Universities; Viral Pathogenesis; Virus; Work; biosafety level 2 facility; comorbidity; computing resources; data acquisition; design; epigenomics; experience; experimental study; genome resource; improved; in vivo; innovation; insight; instrumentation; interdisciplinary approach; interest; meetings; member; metabolomics; multidisciplinary; multiple omics; new technology; pre-exposure prophylaxis; prevent; programs; single cell technology; social; tool; translational scientist; transmission process; virology

PROJECT SUMMARY THIRD COAST CFAR CORE E: VIRAL PATHOGENESIS CORE (VPC) The Viral Pathogenesis Core (VPC) brings highly sophisticated tools, services and reagents of biological HIV research to the interdisciplinary research teams of the TC CFAR. The largest number of VPC users address Overall aim 3: to discover/develop scientific innovations that better prevent HIV and improve treatment of all conditions for persons living with HIV (PLWH). We provide, and are enhancing, consultation and training to facilitate the ability of our diverse teams spanning the breadth of HIV research disciplines at the University of Chicago and Northwestern University to contribute to development of new biological interventions that will reduce transmission of HIV, address the increased risk of chronic diseases of aging in the HIV+ population, and advance HIV cure research. VPC has already strongly grown opportunities for adding biological tools to the work of clinical and behavioral HIV researchers addressing Overall aims 1 (improving HIV prevention and care continuums) and 2 (non-AIDS co-morbidities). New activities will add engagement of laboratory researchers studying aging biology and aging-related disorders who are interested in collaborations on aging in HIV, in support of Overall aim 2. The specific aims of the VP Core are: 1) provide an expanding menu of virological, imaging and immunological assays, as well as consultation and navigation to other disciplines and technologies, that will advance innovative, interdisciplinary HIV research; 2) provide expert design/performance of HIV experiments, as well as consultation/navigation on imaging, systems biology, -omics; 3) strengthen information exchange and partnerships with other HIV research disciplines and with laboratory / translational researchers new to HIV who are interested in non-AIDS comorbidities. The VPC’s cutting edge tools for studying HIV at the molecular, cell, tissue, and organismal levels include highly sophisticated instrumentation; experienced technical support and customized training; and expert consultation / navigation for new technologies, creative experimental designs and innovative pathogenic hypotheses. A primary objective of the VPC is to make these approaches equally available to the molecular virologist, the clinical/translational researcher, and the behavioral/social scientist. VPC adds value and the necessary rigor in all experimentation, including for projects that previously had limited or no access to approaches such as multiplex biomarker assays and virologic assessments. The Data Insight Group (DIG) is expanding consultation and navigation to specialized multi-omics approaches to studies of this virus, as well. The DIG brings together an exciting group of young investigators utilizing advanced technologies in their own research programs as a mechanism to extend incorporation of these approaches into other TC CFAR members’ research. Customized mentorship, navigation and training will also build and strengthen partnerships and collaborations. In this way, the VPC will advance the mission of the TC CFAR to catalyze scientific innovations that will slow, and eventually stop, the HIV epidemic.

项目摘要 第三海岸CFAR核心E：病毒发病机理（VPC） 病毒发病机理核心（VPC）带来了高度复杂的工具，服务和试剂的生物艾滋病毒 向TC CFAR的跨学科研究团队进行研究。数量最多的VPC用户地址 总体目标3：发现/发展科学创新，以更好地防止艾滋病毒并改善所有人的治疗 患有艾滋病毒（PLWH）的人的条件。我们提供并正在加强，咨询和培训 促进我们的潜水团队在大学的艾滋病毒研究学科广度的能力 芝加哥和西北大学为开发新的生物学干预措施做出贡献 减少艾滋病毒的传播，解决艾滋病毒+人口中慢性疾病的风险增加，以及 预先艾滋病毒治愈研究。 VPC已经增加了在工作中添加生物学工具的机会 临床和行为艾滋病毒研究人员针对总体目标1（改善艾滋病毒预防和护理） 连续体）和2个（非辅助合并症）。新活动将增加实验室研究人员的参与 研究对艾滋病毒衰老的合作感兴趣的衰老生物学和与衰老有关的疾病 对总体目标2的支持。副总裁核心的具体目的是：1）提供病毒学的扩展菜单， 成像和免疫学测定，以及其他学科和技术的咨询和导航， 这将推动创新的跨学科HIV研究； 2）提供艾滋病毒的专家设计/表现 实验，以及成像，系统生物学， - 组学的咨询/导航； 3）加强信息 与其他艾滋病毒研究学科以及与实验室 /翻译研究人员的交流和伙伴关系 对非辅助合并症感兴趣的艾滋病毒的新手。 VPC的尖端工具用于研究HIV 分子，细胞，组织和有机水平包括高度复杂的仪器。经验丰富的技术 支持和定制培训；以及新技术的专家咨询 /导航 实验设计和创新的致病假设。 VPC的主要目的是使这些 分子病毒学家，临床/翻译研究人员以及 行为/社会科学家。 VPC在所有实验中增加了价值和必要的严格性，包括项目 以前的方法有限或无法访问诸如多种生物标志物测定和病毒学的方法 评估。数据洞察力组（DIG）将咨询和导航扩展到专业的多摩变 该病毒的研究方法也是如此。挖掘汇集了一群激动人心的年轻调查员 在自己的研究计划中使用高级技术来扩展这些保险 进入其他TC CFAR成员的研究。定制的Mentalship，导航和培训也将 建立和加强伙伴关系和合作。通过这种方式，VPC将推进TC的任务 CFAR催化科学创新，这将放缓并最终阻止HIV流行。