Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)

心力衰竭 (HF) 患者的无创静脉波形分析 (NIVA)

基本信息

批准号：
10580638
负责人：
Kyle Mitchell Hocking
金额：
$ 100万
依托单位：
VOLUMETRIX, LLC
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-21 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10580638
关键词：
Academic Medical Centers Advanced Development Algorithm Design Android Awareness Blood capillaries Breakthrough device COVID-19 Cardiac Catheterization Procedures Categories Certification Clinic Clinical Collaborations Communication Companions Congestive Heart Failure Data Dehydration Development Device Designs Devices Dialysis patients Disease Durable Medical Equipment Early identification Edema Elderly Electronic Health Record Environment Evaluation Experimental Animal Model Fast Healthcare Interoperability Resources Freezing Goals Health Personnel Healthcare Heart failure Home Home environment Hospital Costs Hospitalization Hospitals Human Impairment Incidence Industry Standard Laboratories Lead Leg Legal patent Licensing Life Limb structure Longevity Lung Measurement Measures Medical Medicare Military Personnel Modification Monitor Morbidity - disease rate Outpatients Patients Peripheral Phase Physicians Physiologic Monitoring Physiological Process Provider Pulmonary Capillary Wedge Pressure Qualifying Quality of life Recurrence Shortness of Breath Signal Transduction Signs and Symptoms Small Business Innovation Research Grant Specific qualifier value Swelling Symptoms Technology Telemedicine Tissues Triage Venous Water Work commercialization design diagnostic tool effective therapy experience global health hemodynamics hospital readmission improved manufacture meetings member mobile application mortality non-invasive monitor novel older patient patient population pediatric patients pressure prevent remote monitoring telehealth trend usability validation studies virtual

项目摘要

Project Summary Volume overload (congestion) occurs in patients with heart failure (HF) and is the leading cause of hospitalization in the elderly worldwide. Unfortunately, clinical signs and symptoms; laboratory values; and existing diagnostic tools are unreliable in providing accurate assessment of volume status. Using a unique physiologic signal, Non-Invasive Venous waveform Analysis (NIVA), VoluMetrix has developed a proprietary device and algorithm designed for monitoring volume status in HF patients. Proof of concept data in humans and experimental animal models, demonstrate that NIVA provides a reliable indication of intravascular volume status (“pulmonary capillary wedge equivalent”). The work in this Phase IIB proposal will establish interface and usability studies to complete the process necessary for bridging the gap to commercialization.

项目摘要体积超负荷（拥塞）发生在心力衰竭（HF）的患者中，是主要原因在全球范围内住院。不幸的是，临床体征和符号；实验室价值；现有的诊断工具在提供准确的评估方面是不可靠的体积状态。使用独特的生理信号，非侵入性静脉波形分析（NIVA），体积已开发出一种专有设备和算法，设计用于监测 HF患者的体积状态。人类和实验动物的概念数据证明模型，证明NIVA提供了血管内体积状态的可靠指示（“肺毛细血管楔相等”）。在此阶段，IIB提案的工作将确定界面和可用性研究完成弥合差距所需的过程商业化。