Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)

心力衰竭 (HF) 患者的无创静脉波形分析 (NIVA)

基本信息

批准号：
9789448
负责人：
Kyle Mitchell Hocking
金额：
$ 80.37万
依托单位：
VOLUMETRIX, LLC
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-21 至 2021-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9789448
关键词：
Advanced Development Algorithm Design Algorithmic Analysis Algorithms Ambulatory Monitoring Animals Blood Volume Cardiac Cardiac Catheterization Procedures Clinical Clinical Data Congestive Crystallization Custom Data Devices Diagnostic Elderly Experimental Animal Model Freezing Frequencies Goals Gold Health Personnel Heart failure Hospital Costs Hospitalization Human Intellectual Property Laboratories Leg Linux Lung Measurement Measures Mechanical ventilation Methods Monitor Numerical value Operating System Outpatients Patients Phase Physiological Pulmonary Capillary Wedge Pressure Records Research Shortness of Breath Signal Transduction Signs and Symptoms Small Business Innovation Research Grant Swelling System Tablets Technology Therapeutic Tissues Venous Venous Pressure level Venous system Water Wrist base design hemodynamics hospital readmission improved indexing mortality phase 1 study phase 2 study pressure prevent prototype radiotracer tool trend

Advanced Development Algorithm Design Algorithmic Analysis Algorithms Ambulatory Monitoring Animals Blood Volume Cardiac Cardiac Catheterization Procedures Clinical Clinical Data Congestive Crystallization Custom Data Devices Diagnostic Elderly Experimental Animal Model Freezing Frequencies Goals Gold Health Personnel Heart failure Hospital Costs Hospitalization Human Intellectual Property Laboratories Leg Linux Lung Measurement Measures Mechanical ventilation Methods Monitor Numerical value Operating System Outpatients Patients Phase Physiological Pulmonary Capillary Wedge Pressure Records Research Shortness of Breath Signal Transduction Signs and Symptoms Small Business Innovation Research Grant Swelling System Tablets Technology Therapeutic Tissues Venous Venous Pressure level Venous system Water Wrist base design hemodynamics hospital readmission improved indexing mortality phase 1 study phase 2 study pressure prevent prototype radiotracer tool trend

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项目摘要

Volume overload (congestion) occurs in patients with heart failure (HF) and is the leading cause of hospitalization in the elderly worldwide. Unfortunately, clinical signs and symptoms; laboratory values; and existing diagnostic tools are unreliable in providing accurate assessment of volume status. Using a unique physiologic signal, Non-Invasive Venous waveform Analysis (NIVA), VoluMetrix has developed a proprietary device (“VasaWatch”) and algorithm designed for monitoring volume status in HF patients. Proof of concept data in humans and experimental animal models, demonstrate that VasaWatch provides a reliable indication of intravascular volume status. The studies in this Fast Track SBIR will establish that VasaWatch is a safe, sensitive, inexpensive method for non-invasive volume status monitoring in patients with HF.

体积超负荷（拥塞）发生在心力衰竭（HF）的患者中，是主要原因在全球范围内住院。不幸的是，临床体征和符号；实验室价值；现有的诊断工具在提供准确的评估方面是不可靠的体积状态。使用独特的生理信号，非侵入性静脉波形分析（NIVA），体积已开发了专有设备（“ Vasawatch”）和算法设计用于监测HF患者的体积状态。人类和实验中的概念数据证明动物模型表明，Vasawatch提供了血管内的可靠指示音量状态。在这一快速轨道上的研究将确定vasawatch是一个安全的， HF患者的非侵入性体积状态监测的敏感，廉价的方法。