Translational Hearing Center

转化听力中心

基本信息

批准号：
10579956
负责人：
Peter Stephen Steyger
金额：
$ 211.6万
依托单位：
CREIGHTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-05 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10579956
关键词：
Academic Medical Centers Academic achievement Acceleration Achievement Address Admission activity Advisory Committees Affect Aging Attenuated Auditory Auditory Perception Award Basic Science Biological Assay Biomedical Research Biometry Center for Translational Science Activities Centers of Research Excellence Child Cities Clinical Clinical Investigator Clinical Research Clinical Trials Complement Development Drug Delivery Systems Drug Prescriptions Drug Screening Economic Burden Eligibility Determination Ensure Environment Etiology Evaluation Research Exposure to Fetal Alcohol Spectrum Disorder Fostering Foundations Functional disorder Funding Funding Mechanisms Future Genetic Polymorphism Genomics Goals Grant Great Plains Health Health system Hearing Hearing problem Hospitals Human Impaired cognition Income Individual Infant Inflammation Infrastructure Institution International Intervention Investigation Investigational Drugs Investigational New Drug Application Labyrinth Language Lead Life Longevity Malignant Neoplasms Medical Medical center Mental Depression Mentors Mentorship Military Personnel Mitochondria Multicenter Studies Nebraska Neonatal Intensive Care Units Neural Pathways Noise Noise-Induced Hearing Loss Occupational Peripheral Persons Pharmacologic Substance Phase Pilot Projects Population Production Quality of life Recreation Rehabilitation therapy Research Research Activity Research Personnel Research Project Grants Risk Secure Sensory Services Social Interaction Study Section System Technology Therapeutic Therapeutic Intervention Translating Translational Research Translations Universities Withdrawal aging population base boys candidate identification candidate validation career cisplatin induced hearing loss clinical center drug discovery efficacy study efficacy validation fall risk hearing impairment hearing loss phenotype hearing loss risk hearing preservation hearing restoration high risk lead candidate multidisciplinary neonate ototoxicity patient population pharmacologic preclinical study preservation programs psychosocial recruit safety study skills social socioeconomics success therapeutic candidate translational scientist voucher working group

项目摘要

PROJECT SUMMARY/ABSTRACT Overall Plan for the Translational Hearing Center This Center of Biomedical Research Excellence (COBRE) application is to establish the Translational Hearing Center, administered by centrally-located Creighton University, with Boys Town National Research Hospital (BTNRH) and the University of Nebraska Medical Center (UNMC), as institutional partners. Our overall goal is to build a critical mass of academic translational researchers developing therapeutic interventions to preserve or restore hearing and vestibular function from a wide range of etiologies that cause hearing loss and vestibular deficits. Hearing loss in infants and children results in delayed acquisition of listening and spoken language skills critical for academic achievement and maximal career trajectories of affected individuals. In the aging population, hearing loss and vestibular deficits without appropriate rehabilitation accelerates aging and cognitive decline. Aim 1: Develop the infrastructure and expertise base for translational auditory and vestibular research. COBRE funding will enable an Administrative Core within the Center to provide a unique, transformational research environment for junior investigators to translate their basic science discoveries into therapeutic strategies that preserve or restore hearing and vestibular function. This will establish a broader nonclinical research program. The Administrative Core will coordinate interactions between project leaders with their Mentors, and an External Advisory Committee. The Administrative Core will develop a Drug Discovery and Delivery Core that will coordinate necessary drug screen assays and production of derivatives of lead compounds and their delivery to the inner ear and associated central neural pathways, as well as an Auditory Vestibular Technology Core to validate the efficacy of lead candidate ototherapeutics hits. Aim 2: Build a critical mass of funded investigators leading translational auditory and vestibular research. We will examine both peripheral and central mechanisms of hearing loss and vestibular dysfunction, and identify pharmacotherapeutic strategies preserve or restore hearing and vestibular function, with multiple levels of research funding for investigators. We also have an outstanding Mentoring Plan for project leaders, complementing their expertise with senior investigations as Internal Mentors and biostatistical support, as well as outside investigators with translational and clinical expertise as External Mentors. Additional mentoring is provided by Research Core staff, grantsmanship classes and Mock Study Sections of proposals prior to review. Evaluations of research progress, and all other Center activities, are also key to optimize Center success. The Center will also benefit from the burgeoning translational research environment in Omaha, Nebraska. Future plans call for continued expansion of the Center to include submission of Investigational New Drug applications, safety and efficacy studies and clinical trials in partnership with patient populations served by Creighton University’s academic medical center, Catholic Health Initiatives (CHI) Health system, BTNRH and UNMC.

项目摘要/摘要翻译听证中心的总体计划这个生物医学研究卓越中心（COBRE）的应用是建立转化听证会中心，由中央位置的克雷顿大学（Creighton University）管理，男孩镇国家研究医院（BTNRH）和内布拉斯加州大学医学中心（UNMC），作为机构合作伙伴。我们的总体目标是建立大量的学术翻译研究人员，开发治疗干预措施以保存或恢复听力和前庭功能，来自多种病因，导致听力损失和前庭缺陷。婴儿和儿童的听力损失导致听力和口语技能的获取延迟对学术成就和受影响个人的最大职业轨迹至关重要。在老龄化的人口中，听力损失和前庭无适当的康复定义会加速衰老和认知能力下降。目标1：为翻译听觉和前庭研究开发基础设施和专业知识基础。毛cr融资将使中心内的行政核心能够提供独特的变革性初级研究人员的研究环境将其基础科学发现转化为治疗保留或恢复听力和前庭功能的策略。这将建立更广泛的非临床研究计划。行政核心将协调项目负责人之间的互动导师和外部咨询委员会。行政核心将开发出药物发现，并交付核心将协调必要的药物筛选分析和生产铅的衍生物化合物及其到内耳和相关的中央神经通路以及礼堂前庭技术核心，以验证铅候选术的效率。目的2：建立大量资助的研究人员，领先的翻译听觉和前庭研究。我们将检查听力丧失和前庭功能障碍的外围和中心机制，并确定药物治疗策略保留或恢复听力和前庭功能，多个研究人员的研究资金水平。我们还为项目负责人制定了出色的指导计划，通过作为内部导师和生物统计学支持的高级调查来完成他们的专业知识作为外部研究人员，具有翻译和临床专业知识为外部导师。其他指导是由研究核心人员，授予技巧课程和审查前提案的模拟研究部分提供。研究进度以及所有其他中心活动的评估也是优化中心成功的关键。该中心还将受益于内布拉斯加州奥马哈市的毛刺翻译研究环境。未来计划要求继续扩展中心，包括提交调查新药申请，与Creighton服务的患者人群合作的安全性和有效研究和临床试验大学的学术医学中心，天主教卫生计划（CHI）卫生系统，BTNRH和UNMC。