Determining the Longer-term Impact of COVID-19 Stressors, Alcohol Use and Neurobiobehavioral Decline in Older Adults Through Prospective Study

通过前瞻性研究确定 COVID-19 压力源、饮酒和神经生物行为下降对老年人的长期影响

• 批准号: 10579335
• 负责人: SARA JO NIXON
• 金额: $ 37.63万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10579335
• 关键词: Accounting; Acute; Address; Age; Aging; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Black race; COVID-19; COVID-19 impact; COVID-19 pandemic; Chronic; Contracts; Data; Distress; Elderly; Emotional; Ethnic Origin; Female; Health; Health Planning; Heavy Drinking; Impaired cognition; Indigenous; Light; Link; Literature; Loneliness; Longitudinal Studies; Masks; Measures; Mediation; Mediator; Methods; Modeling; Outcome; Pain; Pathway interactions; Patient Self-Report; Pattern; Performance; Phase; Prevention; Process; Prospective Studies; Public Health; Race; Reporting; Research; Risk; Risk Factors; Role; Severities; Sex Differences; Sleep disturbances; Social Distance; Social isolation; Stress; Time; Vaccinated; Variant; Woman; Work; aged; biopsychosocial; chronic pain; cognitive function; critical period; design; drinking; experience; infection rate; long term consequences of COVID-19; longitudinal, prospective study; male; marijuana use; men; multimodality; negative affect; neurophysiology; novel; optimism; pandemic disease; pandemic potential; people of color; prospective; psychological distress; psychological stressor; racial minority; response; sex; sleep quality; social; social engagement; stressor; transmission process; vaccine hesitancy; Accounting; Acute; Address; Age; Aging; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Black race; COVID-19; COVID-19 impact; COVID-19 pandemic; Chronic; Contracts; Data; Distress; Elderly; Emotional; Ethnic Origin; Female; Health; Health Planning; Heavy Drinking; Impaired cognition; Indigenous; Light; Link; Literature; Loneliness; Longitudinal Studies; Masks; Measures; Mediation; Mediator; Methods; Modeling; Outcome; Pain; Pathway interactions; Patient Self-Report; Pattern; Performance; Phase; Prevention; Process; Prospective Studies; Public Health; Race; Reporting; Research; Risk; Risk Factors; Role; Severities; Sex Differences; Sleep disturbances; Social Distance; Social isolation; Stress; Time; Vaccinated; Variant; Woman; Work; aged; biopsychosocial; chronic pain; cognitive function; critical period; design; drinking; experience; infection rate; long term consequences of COVID-19; longitudinal, prospective study; male; marijuana use; men; multimodality; negative affect; neurophysiology; novel; optimism; pandemic disease; pandemic potential; people of color; prospective; psychological distress; psychological stressor; racial minority; response; sex; sleep quality; social; social engagement; stressor; transmission process; vaccine hesitancy

Project Summary/Abstract Although the COVID-19 pandemic is leaving no one untouched, the health of older adults and Black, Indigenous and other people of color (BIOPC) has been disproportionately impacted. Further, the emergent variants and data demonstrating that at least some variants can be contracted and transmitted by those vaccinated are accompanied by continued messaging emphasizing mask-wearing and social distancing, exacerbating concerns of social re-engagement. An extant literature demonstrates that social distancing is linked to a host of biopsychosocial consequences including psychological distress, loneliness, sleep disruption, pain severity, and of particular relevance here, escalation in alcohol use and cognitive decline. Critically, these outcomes have noted interactions and are particularly disadvantageous in the context of concurrent aging processes. Thus, there are compelling arguments for study of biopsychosocial outcomes of the COVID-19 pandemic among older adults. Additionally, given the disproportionate impact on BIOPC and studies (albethey limited) illustrating race- related differences in vulnerability to isolation related stressors, it is imperative that purposeful study of the role of race/ethnicity be conducted. Finally, although there is a large literature detailing female sex as a risk factor for increased vulnerability for psychological distress and related outcomes, the manner and degree to which such risk would be evidenced in light of the prolonged COVID-19 pandemic and as a function of age and race/ethnicity is not known. Currently emerging data address some of these issues as they were experienced in early phases of the pandemic. However, characterizing the long-term consequences of this prolonged pandemic requires conceptually-driven longitudinal study, expeditiously initiated. If delayed, information fundamental to scientific progress and public health programming will be missed. Thus, guided by RFA AA-21-002 and existing data, we propose a prospective, multi-method/multi-modal longitudinal study directed to clarifying the interactive effects of COVID-19 stressors (i.e., sleep quality, psychological distress, loneliness/negative affect and chronic pain), alcohol use and neurobiobehavioral decline/stability in 160 older (age 65-75) male and female current drinkers (n=80 each) of both majority and minority race/ ethnicity (60/40 distribution) while controlling for essential covariates such as emotional and physical proximity to COVID-19. Through longitudinal assessment across 3 years, we will define the pandemic’s evolving impact and clarify significant modulators of outcomes. Together, these data will inform both scientific questions regarding the long-term impact of COVID-19 stressors, patterns of alcohol use, and neurobiobehavioral change and public health planning and prevention efforts.

项目摘要/摘要 尽管COVID-19大流行尚未触及，但老年人和黑人，本土的健康 和其他有色人种（BIOPC）受到了不成比例的影响。此外，紧急变体和 数据表明，至少可以通过疫苗接种的人会收缩和传输一些变体 伴随着持续的消息传递强调戴面具和社会疏远，加剧 社会重新参与的担忧。扩展的文献表明，社会距离与许多 生物心理社会后果，包括心理困扰，孤独，睡眠中断，疼痛严重程度和 在这里特别相关的是，酒精使用和认知能力下降。至关重要的是，这些结果有 指出的相互作用，在并发衰老过程的背景下特别受到干扰。那， 有令人信服的论据，以研究较老的19009年大流行的生物心理社会结局 成年人。此外，鉴于对BioPC和研究的不成比例影响（Albethey Limited），说明了种族 与隔离相关的压力源的脆弱性相关差异，必须有目的地研究该角色 进行种族/种族。最后，尽管有大量的文献将女性详细介绍为危险因素 增加了心理困扰和相关结果的脆弱性，这种方式和程度 鉴于长时间的共同流行病和年龄和种族/种族的关系，风险将得到证明 不知道。目前，新兴数据解决了其中一些问题，因为它们在早期阶段经历了 大流行。但是，表征这一长期大流行的长期后果需要 以概念为导向的纵向研究，迅速启动。如果延迟，科学基础的信息 进步和公共卫生节目将被错过。在RFA AA-21-002和现有数据的指导下，我们 提议一项前瞻性，多方法/多模式纵向研究，旨在阐明互动效应 COVID-19压力源（即睡眠质量，心理困扰，孤独/负面影响和慢性疼痛）， 160岁（65-75岁）的雄性和女性饮酒者的酒精使用和神经be虫的下降/稳定性 （n = 80）多数和少数族裔/民族（60/40分布），同时控制着必需品 协变量诸如与COVID-19的情感和身体接近。通过3个纵向评估 多年来，我们将定义大流行的影响，并阐明重要的结果调节剂。一起， 这些数据将为COVID-19压力源的长期影响，模式带来两个科学问题。 饮酒，神经be虫的变化以及公共卫生计划和预防工作。