Neurobehavioral & emotional deficits in male & female alcoholics

神经行为

• 批准号: 8562490
• 负责人: SARA JO NIXON
• 金额: $ 37万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-20 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8562490
• 关键词: Accounting; Address; Age; Alcohol abuse; Alcohol dependence; Alcohol or Other Drugs use; Alcoholism; Alcohols; Chronic; Cognitive; Communities; Data; Dependence; Drug abuse; Educational Background; Emotional; Emotions; Etiology; Exhibits; Expressed Emotion; Face; Face Processing; Female; Gender; Impairment; Individual; Knowledge; Literature; Measurement; Modeling; Neurocognitive; Outcome; Performance; Process; Process Measure; Recording of previous events; Recovery; Relative (related person); Reporting; Research; Sample Size; Sampling; Sex Characteristics; Smoking; Stimulus; Substance Use Disorder; Testing; Woman; Work; alcohol sensitivity; base; clinically relevant; drinking; emotional adjustment; emotional stimulus; experience; male; men; neurobehavior; neurobehavioral; neuropsychological; problem drinker; public health relevance; response; sex

DESCRIPTION (provided by applicant): As detailed in PA-11-047 (Women and sex/gender differences in drug and alcohol abuse/dependence), gender differences in the etiology, progression, and consequences of substance use disorders (SUDs) remain incompletely understood. The current proposal focuses on one important aspect of this gap; consequences. More specifically, it is directed to clarifying how men and women may differentially experience the neurobehavioral consequences of alcohol dependence. It is noteworthy that most research directed to neurobehavioral assessments has focused on traditionally defined neurocognitive/ neuropsychological domains. Another compromised component of neurobehavior and a key aspect of successful adaptation, emotional processing, has been examined primarily in a separate literature. To better understand the breadth of neurobehavioral compromise, concurrently assessing neurocognitive and emotional performance in men and women is required. Furthermore, although studies of community samples typically reveal a female advantage on these tasks, gender differences among alcoholics are infrequently addressed. To enhance interpretation and direct future research, it is imperative that this work be conceptually driven. In response to these issues, we propose to assess cognitive and emotional functions in sufficient samples of male and female detoxified alcoholics (n=100, 50 females) and community controls (n=100, 50 females) to address both main and interaction effects. Guiding this work is a conceptual model which directs testable hypotheses, thereby informing future research and providing clinically relevant information concerning the processes underlying alcohol-related neurobehavioral (i.e., cognitive and emotional) impairment.

描述（由申请人提供）：如PA-11-047中所述（毒品和酒精滥用/依赖性的妇女以及性别/性别差异），对物质使用障碍（SUD）的病因，进展和后果的性别差异（SUD）仍然不完全理解。当前的提案重点是这一差距的一个重要方面。结果。更具体地说，它旨在阐明男人和女人如何差异化酒精依赖的神经行为后果。值得注意的是，大多数针对神经行为评估的研究都集中在传统上定义的神经认知/神经心理学领域。神经行为的另一个妥协组成部分和成功适应的关键方面，情感处理，主要在单独的文献中进行了研究。为了更好地了解神经行为妥协的广度，需要同时评估男性和女人的神经认知和情感表现。此外，尽管对社区样本的研究通常揭示了这些任务上的女性优势，但酗酒者之间的性别差异很少得到解决。为了增强解释和指导未来的研究，必须在概念上驱动这项工作。为了应对这些问题，我们建议评估男性和女性排毒酗酒者（n = 100，50女性）和社区控制（n = 100，50女性）的足够样本中的认知和情感功能，以解决主要和相互作用的影响。指导这项工作是一种概念模型，该模型指导可检验的假设，从而为未来的研究提供了信息，并提供了有关与酒精相关的神经行为（即认知和情感）损害的临床相关信息。