Determining the Longer-term Impact of COVID-19 Stressors, Alcohol Use and Neurobiobehavioral Decline in Older Adults Through Prospective Study

通过前瞻性研究确定 COVID-19 压力源、饮酒和神经生物行为下降对老年人的长期影响

• 批准号: 10470537
• 负责人: SARA JO NIXON
• 金额: $ 36.92万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470537
• 关键词: Accounting; Acute; Address; Age; Aging; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Black race; COVID-19; COVID-19 impact; COVID-19 pandemic; Chronic; Contracts; Data; Distress; Elderly; Emotional; Ethnic Origin; Female; Health; Health Planning; Heavy Drinking; Impaired cognition; Indigenous; Light; Link; Literature; Loneliness; Longitudinal Studies; Masks; Measures; Mediation; Mediator of activation protein; Methods; Minority; Modeling; Outcome; Pain; Pathway interactions; Patient Self-Report; Pattern; Performance; Phase; Prevention; Process; Prospective Studies; Public Health; Race; Reporting; Research; Risk; Risk Factors; Role; Severities; Sex Differences; Sleep disturbances; Social Distance; Social isolation; Stress; Time; Vaccinated; Variant; Woman; Work; aged; base; biopsychosocial; chronic pain; cognitive function; critical period; design; drinking; experience; infection rate; long term consequences of COVID-19; male; marijuana use; men; multimodality; negative affect; neurophysiology; novel; optimism; pandemic disease; people of color; prospective; psychological distress; psychological stressor; response; sex; sleep quality; social; social engagement; stressor; vaccine hesitancy

Project Summary/Abstract Although the COVID-19 pandemic is leaving no one untouched, the health of older adults and Black, Indigenous and other people of color (BIOPC) has been disproportionately impacted. Further, the emergent variants and data demonstrating that at least some variants can be contracted and transmitted by those vaccinated are accompanied by continued messaging emphasizing mask-wearing and social distancing, exacerbating concerns of social re-engagement. An extant literature demonstrates that social distancing is linked to a host of biopsychosocial consequences including psychological distress, loneliness, sleep disruption, pain severity, and of particular relevance here, escalation in alcohol use and cognitive decline. Critically, these outcomes have noted interactions and are particularly disadvantageous in the context of concurrent aging processes. Thus, there are compelling arguments for study of biopsychosocial outcomes of the COVID-19 pandemic among older adults. Additionally, given the disproportionate impact on BIOPC and studies (albethey limited) illustrating race- related differences in vulnerability to isolation related stressors, it is imperative that purposeful study of the role of race/ethnicity be conducted. Finally, although there is a large literature detailing female sex as a risk factor for increased vulnerability for psychological distress and related outcomes, the manner and degree to which such risk would be evidenced in light of the prolonged COVID-19 pandemic and as a function of age and race/ethnicity is not known. Currently emerging data address some of these issues as they were experienced in early phases of the pandemic. However, characterizing the long-term consequences of this prolonged pandemic requires conceptually-driven longitudinal study, expeditiously initiated. If delayed, information fundamental to scientific progress and public health programming will be missed. Thus, guided by RFA AA-21-002 and existing data, we propose a prospective, multi-method/multi-modal longitudinal study directed to clarifying the interactive effects of COVID-19 stressors (i.e., sleep quality, psychological distress, loneliness/negative affect and chronic pain), alcohol use and neurobiobehavioral decline/stability in 160 older (age 65-75) male and female current drinkers (n=80 each) of both majority and minority race/ ethnicity (60/40 distribution) while controlling for essential covariates such as emotional and physical proximity to COVID-19. Through longitudinal assessment across 3 years, we will define the pandemic’s evolving impact and clarify significant modulators of outcomes. Together, these data will inform both scientific questions regarding the long-term impact of COVID-19 stressors, patterns of alcohol use, and neurobiobehavioral change and public health planning and prevention efforts.

项目概要/摘要 尽管新冠肺炎 (COVID-19) 大流行没有人不受影响，但老年人和黑人、原住民的健康 和其他有色人种 (BIOPC) 受到的影响尤为严重。 数据表明，这些疫苗至少可以感染和传播某些变种 伴随着不断强调戴口罩和保持社交距离的信息，加剧了 现有文献表明，社交距离与许多因素有关。 生物心理社会后果，包括心理困扰、孤独、睡眠中断、疼痛严重程度和 与此特别相关的是，酒精使用的增加和认知能力的下降。 注意到相互作用，并且在同时老化过程的情况下特别不利。 对于老年人中 COVID-19 大流行的生物心理社会结果的研究有令人信服的论据 此外，考虑到对 BIOPC 的不成比例的影响以及说明种族的研究（尽管有限） 由于对孤立相关压力源的脆弱性存在相关差异，因此有必要对角色进行有目的的研究 最后，尽管有大量文献详细说明女性性别是一个危险因素。 心理困扰和相关结果的脆弱性增加，这种情况的方式和程度 鉴于长期的 COVID-19 大流行以及年龄和种族/民族的函数，风险将得到证明 目前尚不清楚，目前出现的数据解决了其中一些问题，因为这些问题在早期阶段就已经经历过。 然而，要描述这种长期流行病的长期后果需要 概念驱动的纵向研究，如果延迟，将获得对科学至关重要的信息。 因此，在 RFA AA-21-002 和现有数据的指导下，我们将错过进展和公共卫生规划。 提出一项前瞻性、多方法/多模式纵向研究，旨在阐明交互作用 COVID-19 压力源（即睡眠质量、心理困扰、孤独/负面情绪和慢性疼痛）， 160 名老年（65-75 岁）男性和女性当前饮酒者的饮酒和神经生物行为下降/稳定性 （n = 80 各）大多数和少数种族/族裔（60/40 分布），同时控制基本要素 通过跨 3 项的纵向评估来确定协变量，例如与 COVID-19 的情感和身体接近度。 多年来，我们将共同定义这一流行病不断变化的影响，并明确结果的重要调节因素。 这些数据将为有关 COVID-19 压力源、模式的长期影响的科学问题提供信息 酒精使用、神经生物行为变化以及公共卫生规划和预防工作。