Racial Disparities in Accuracy of Pulse Oximetry

脉搏血氧饱和度准确性的种族差异

• 批准号: 10579316
• 负责人: Heather M Siefkes
• 金额: $ 6.63万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10579316
• 关键词: Accident and Emergency department; Adult; Age; Bilirubin; Blood Transfusion; Blood capillaries; Blood gas; Caring; Clinical Trials; Collaborations; Darkness; Data; Detection; Devices; Diagnosis; Disease; Disparity; Dissociation; Duct (organ) structure; Equipment and Supplies; Erythrocyte Transfusion; Erythrocytes; Future; Gender; Gestational Age; Hemoglobin; Hemoglobin A; Hypoxemia; Hypoxemic Respiratory Failure; Incidence; Individual; Infant; Infrastructure; Lead; Life; Light; Lung diseases; Measurement; Measures; Medical; Melanins; Multicenter Studies; Necrotizing Enterocolitis; Neonatal; Neonatal Intensive Care Units; Newborn Infant; Outcome; Oxygen; Packed Red Blood Cell Transfusion; Partial Pressure; Patients; Peripheral; Physiologic pulse; Physiological; Premature Infant; Prospective cohort; Pulmonary Hypertension; Pulse Oximetry; Research; Resuscitation; Risk; Severities; Skin; Skin Pigmentation; Source; Testing; Thinness; Titrations; Transfusion; United States Food and Drug Administration; clinically significant; cohort; congenital heart disorder; critically ill newborn; disease diagnosis; experience; indexing; infant monitoring; innovation; member; mortality; multidisciplinary; neonatal pulmonary hypertension; neonate; oxygen toxicity; postnatal; racial difference; racial disparity; routine care; screening; sensor; sex; skin color; standard measure; supplemental oxygen; targeted treatment

PROJECT SUMMARY/ABSTRACT We propose to assess the correlation between arterial oxygen saturation (SaO2) and peripheral oxygen saturation measured by pulse oximetry (SpO2) discrepancy and skin pigmentation. Recent data demonstrated that pulse oximetry devices overestimate SpO2 in darker skin adults. This is less understood in newborns. However, medical conditions associated with hypoxemia occur more commonly in black infants and the conditions associated with hyperoxemia occur less frequently in black infants. Thus, raising the question if pulse oximeters overestimate SpO2 in black infants and falsely putting them in the “safe” zone. We will measure simultaneous SaO2 and SpO2 among varying degrees of skin pigmentation while accounting for other physiologic variables such as gestational age, receipt of red blood cells, bilirubin, and sex, to assess the impact of skin pigmentation on the SaO2-SpO2 discrepancy. Members of our team have experience with research related to oxygen targeted therapies and pulse oximetry in newborns. Additionally, our team members have experience working with recorded pulse oximetry data and have received support from the leading pulse oximeter device company to supply equipment and sensors for this proposal. The proposed research is significant because it will answer the question if pulse oximetry bias due to skin color occurs to a degree that is clinically significant and could cause harm for newborns with darker skin. Results from this study will inform a larger trial in which we will assess the effect of postnatal age on pulse oximetry accuracy and multiple oximeters and will impact how pulse oximetry is used for infants of varying skin color in routine care such CCHD screening, SpO2 targeted care and future clinical trials. Additionally, this is innovative because it will use readily available SpO2 and SaO2 measurements from infants with varying degrees of light and dark skin to assess pulse oximeter bias and imprecision and will use a noninvasive device to measure melanin index to quantify skin pigmentation. Additionally, it will take into consideration other physiologic impacts on SpO2 such as gestational age, degree of hypoxemia, gender, and red blood cell transfusion. Through collaboration between two neonatal intensive care units, we will establish the infrastructure and necessary multidisciplinary relationships that can later be expanded to conduct future multicenter studies to evaluate the potential disparity from pulse oximeters and how it correlates with skin pigmentation.

项目摘要/摘要 我们建议评估动脉氧饱和度（SAO2）和外皮氧之间的相关性 通过脉搏血氧饱和度（SPO2）差异和皮肤色素沉着测量 脉搏血氧仪的设备高估了较深的皮肤成年人的SPO2。 但是，与低氧血症有关的医疗状况更常见于黑人婴儿和你 与黑人婴儿相关的疾病频率较低。 脉搏血氧仪高估了黑人婴儿的spo2，然后将spo2放在“安全”区域中 在不同程度的皮肤色素沉着中测量同时的SAO2和SPO2，同时考虑其他 生理变量，例如胎龄，红细胞的接受，胆红素和性别，以评估它们 皮肤色素沉着对SAO2-SPO2差异的影响。 我们团队的成员具有与Reach相关的毒品靶向疗法和脉搏的经验 新生儿中的血氧仪。 数据并已获得领先的脉搏血氧仪设备Commpany的支持，以供应设备和 该投影的传感器。 拟议的研究是重要的，因为它会遇到问题是否存在 肤色在临床上具有重要意义，可能对皮肤深色的新生儿造成伤害。 研究的结果将在较大的试验中评估产后年龄对脉搏对脉冲的影响 血氧仪准确性和多种血氧仪，并将影响脉搏血氧饱和度的使用方式 常规护理中的颜色CCHD筛查，SPO2有针对性的护理和未来的临床试验。 创新元素，因为它将可用的SPO2和SAO2测量。 轻度和深色皮肤评估脉搏血氧仪偏置和不合理的脉搏血氧仪偏置将无创设备 为了测量黑色素指数以量化皮肤色素沉着。 SPO2的生理学症 输血。 基础架构和必要的多学科关系，以后可以扩展以进行未来 多中心研究以评估脉搏血氧仪的潜在差异及其与皮肤的相关性 色素沉着。