Training Program in Infectious Diseases in the Immunocompromised Host

免疫功能低下宿主传染病培训计划

• 批准号: 10270735
• 负责人: MICHAEL J BOECKH
• 金额: --
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10270735
• 关键词: Communicable Diseases; Immunocompromised Host; Training Programs

PROJECT SUMMARY Our interdisciplinary training program, based at the Fred Hutchinson Cancer Research Center (Fred Hutch), focuses on Infectious Diseases in the Immunocompromised Host. Our objective is to recruit and train outstanding physician-scientists and postdoctoral PhD scientists to perform basic, translational and clinical research, using state-of-the-art methods and analytical techniques. Our overarching goal is to train the next generation of leaders in the field, who will use their expertise to advance our understanding of infectious disease biology and pathogenesis, and to develop novel strategies to prevent, treat and control infectious diseases in high-risk immunocompromised patients. There is increasing demand for research training in this field: infection remains a major cause of morbidity and mortality for immunocompromised hosts, and millions are at risk or affected by established pathogens and emerging pathogens such as SARS-CoV-2. The population of immunocompromised individuals in the United States continues to grow, driven by advances in transplantation techniques and cancer treatments, increased survival of these patients, and the development of novel drugs and biological agents to treat autoimmune diseases. As part of an NCI-designated cancer consortium whose renowned faculty have contributed landmark advances in the field of infectious diseases of the immunocompromised host for the past 40 years, and whose expertise collectively encompass all facets of this field, Fred Hutch is uniquely positioned to successfully lead this training program. In partnership with the University of Washington (UW), the Infectious Disease Sciences Program of Fred Hutch has an excellent, multi-decade track record of training physician-scientists and postdoctoral PhD scientists who launch independent research careers in academia, government research, or industry leadership positions. Our funded T32 grant has allowed us to expand our training program and solidify funding for trainees in this specialized area of infectious diseases. We seek to maintain this high standard of training; the T32 will support 2 new, qualified trainees (MDs and/or PhDs) per year, for 3 years of training each. T32 trainees pursue one of three consolidated research tracks that represent the unique strengths of our immunocompromised host program and its mentors: 1) Clinical Research, Infection Prevention, and Stewardship; 2) Immunology/Immunogenetics; and 3) Microbiome and Pathogenesis. These tracks provide training in unique aspects of this field and will assure that trainees develop expertise in epidemiology, diagnosis, management and host-pathogen interactions. All trainees participate in a rigorous core curriculum consisting of courses, lectures, retreats, research and targeted career development activities; trainees also have the opportunity to complete a master’s degree at UW. Our training program helps to address the national need for researchers that focus their clinical and/or laboratory investigation on Infectious Diseases in the Immunocompromised Host, and provides those trainees with the skills and expertise to successfully transition into independent research careers.

项目摘要 我们的跨学科培训计划，位于弗雷德·哈钦森癌症研究中心（Fred Hutch）， 专注于免疫功能低下宿主中的传染病。我们的目标是招募和培训 杰出的身体科学家和博士后博士科学家将表演基本，翻译和临床 研究，使用最先进的方法和分析技术。我们的总体目标是训练下一个 该领导者的产生产生，他们将利用他们的专业知识来促进我们对感染性的理解 疾病生物学和发病机理，并制定新的策略来预防，治疗和控制感染性 高风险免疫功能低下的患者的疾病。对研究培训的需求不断增加 现场：感染仍然是免疫功能低下宿主发病和死亡率的主要原因，数百万 有危险或受到已建立的病原体和新兴病原体（例如SARS-COV-2）的影响。这 在美国的免疫力低下个体人口继续增长，在进步的推动下 移植技术和癌症治疗，这些患者的存活率增加以及发展 治疗自身免疫性疾病的新型药物和生物学毒剂。作为NCI指定的癌症的一部分 著名教职员工在传染病领域取得了里程碑意义的进步的财团 在过去的40年中，免疫功能低下的主持人，其专业知识共同涵盖了 在这个领域，弗雷德·哈奇（Fred Hutch）的位置是成功领导该培训计划的独特位置。与 华盛顿大学（UW），弗雷德·哈奇（Fred Hutch）的传染病科学计划 培训物理科学家和博士后博士科学家的多年历史记录 学术界，政府研究或行业领导职务的独立研究职业。我们的资助 T32 Grant允许我们扩大我们的培训计划，并在此专业中为受训者提供资金 传染病区域。我们试图维持这种高标准的培训； T32将支持2个新的 每年合格的学员（MDS和/或PHD），每年进行3年的培训。 T32学员追求三个 合并的研究轨道代表了我们免疫功能低下的主机计划的独特优势 及其导师：1）临床研究，预防感染和管理； 2）免疫学/免疫遗传学； 3）微生物组和发病机理。这些轨道在该领域的独特方面提供培训，并将 确保学员在流行病学，诊断，管理和宿主病原上发展专业知识 互动。所有学员都参加了一个严格的核心课程，包括课程，讲座，务虚会， 研究和针对职业发展活动；学员也有机会完成硕士 UW学位。我们的培训计划有助于满足针对临床专注的研究人员的国家需求 和/或实验室对免疫功能低下宿主中传染病的调查，并提供这些调查 具有技能和专业知识的学员可以成功地过渡到独立的研究职业。