Training Program in Infectious Diseases in the Immunocompromised Host

免疫功能低下宿主传染病培训计划

• 批准号: 9925732
• 负责人: MICHAEL J BOECKH
• 金额: $ 32.39万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925732
• 关键词: Communicable Diseases; Immunocompromised Host; Training Programs

PROJECT SUMMARY We seek to establish an interdisciplinary training program at the Fred Hutchinson Cancer Research Center (Fred Hutch) focused on Infectious Diseases in the Immunocompromised Host. The purpose of the program is to train physician-scientists and post-doctoral PhD scientists to perform basic, translational and clinical research in the biology, pathogenesis, diagnosis, treatment and prevention of infectious diseases in high-risk immunocompromised patients. Novel drugs and biological agents to treat autoimmune diseases, advances in transplantation techniques and cancer treatments as well as increased survival of these patients have resulted in a significant growth in the population of patients with immunosuppression in the United States. Infection remains a major cause of morbidity and mortality for immunocompromised hosts, and with millions at risk or affected by emerging and established pathogens, there is increasing demand for research training in this field. The Infectious Disease Sciences Program of the Fred Hutch has partnered with the University of Washington in training 50 Infectious Disease fellows and postdoctoral scientists in laboratory or translational research in the area of Infectious Diseases in the immunocompromised host over the last 25 years. We have an excellent track record of transitioning trainees to full career independence at the conclusion of their training with more than 80% of our trainees now working in academia, government research or industry leadership positions. There is a clear need to both expand our training program and solidify funding for trainees in this specialized area of Infectious Diseases. We are requesting funding to support two qualified trainees (MDs and/or PhDs) per year, for two years of training for each of the trainees. This funding will be utilized for training in one of 4 research tracks that represent the unique strengths of our immunocompromised host program and its mentors: 1) Epidemiology, Pathogen Dynamics, and Clinical Trials; 2) Immunology/Immunogenetics; 3) Microbiome and Pathogenesis; and 4) Infection Prevention and Hospital Epidemiology. These tracks provide training in unique aspects of this field and will assure that trainees develop expertise in epidemiology, diagnosis, management and host-pathogen interactions. All trainees will participate in a rigorous core curriculum consisting of courses, lectures, retreats, research, and targeted career development activities; trainees also have the opportunity to complete a Masters in Public Health degree at the University of Washington. The proposed training program will help to address the national need for researchers that focus their clinical and/or laboratory investigation on Infectious Diseases in the Immunocompromised Host, and will provide those trainees with the skills and expertise to successfully transition into independent research careers.

项目摘要 我们试图在弗雷德·哈钦森癌症研究中心建立跨学科培训计划 （Fred Hutch）专注于免疫功能低下的宿主中的传染病。该程序的目的是 培训医师科学家和博士后博士学位科学家，以执行基本，转化和临床 在高危中的生物学，发病机理，诊断，治疗和预防传染病的研究 免疫功能低下的患者。新型药物和生物学毒剂治疗自身免疫性疾病，进展 移植技术和癌症治疗以及这些患者的存活率增加已导致 在美国，免疫抑制患者人群的显着增长。感染 仍然是免疫功能低下宿主发病和死亡率的主要原因，数百万的风险或 受新兴和已建立的病原体的影响，该领域对研究培训的需求不断增加。 弗雷德·哈奇（Fred Hutch）的传染病科学计划与华盛顿大学合作 在培训中，在实验室或翻译研究中的50名传染病研究员和博士后科学家 过去25年中，免疫功能低下的宿主中传染病区域。我们有一个很好的 在培训结束时，过渡学员过渡到完全职业独立的记录与更多 现在，我们80％的学员现在从事学术界，政府研究或行业领导职务。 显然需要扩大我们的培训计划，并在此专业中巩固对学员的资金 传染病区域。我们要求资金支持两名合格的学员（MDS和/或PHD） 每年，为每位受训人员进行两年的培训。这笔资金将用于4个之一 代表我们免疫功能低下的宿主计划及其导师的独特优势的研究轨道： 1）流行病学，病原体动力学和临床试验； 2）免疫学/免疫遗传学； 3）微生物组和 发病; 4）预防感染和医院流行病学。这些曲目提供了独特的培训 该领域的各个方面，并将确保受训者在流行病学，诊断，管理方面发展专业知识 和宿主病原体相互作用。所有学员将参加由课程组成的严格核心课程， 讲座，务虚会，研究和针对性的职业发展活动；学员也有机会 在华盛顿大学获得公共卫生学位的硕士学位。拟议的培训计划 将有助于满足针对临床和/或实验室调查的研究人员的国家需求 免疫功能低下的宿主中的传染病，将为这些受训者提供技能和 专业知识可以成功过渡到独立的研究事业。