BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10487660
• 负责人: Gayatri Vedantam
• 金额: --
• 依托单位: SOUTHERN ARIZONA VA HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10487660
• 关键词: Active Listening; Address; Age; Anaerobic Bacteria; Animal Model; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics; Arizona; Australia; Award; Bacillus; Bacteria; Bacterial Infections; Basic Science; Biological Response Modifier Therapy; Book Chapters; Canada; Carbohydrates; Cells; Cellular biology; Centers for Disease Control and Prevention (U.S.); Clinical; Clostridium difficile; Collaborations; Communicable Diseases; Communication; Communities; Disclosure; Disease; Elderly; Epidemic; Epidemiology; Escherichia coli EHEC; Faculty; Feedback; Fingerprint; First Generation College Students; Fostering; Funding; Genetic; Genomic Islands; Genomics; Goals; Health; Healthcare; Healthcare Systems; Hospitalization; Hospitals; Human; Illinois; Immunocompromised Host; Incidence; Infection; Intellectual Property; Intercellular Junctions; International; Intervention; Intestines; Investigation; Knowledge; Laboratories; Legal patent; Medical; Medical Students; Medical center; Mentors; Mentorship; Methods; Microbial Biofilms; Microscopy; Molecular; Monograph; Nature; Oral; Organism; Paper; Paris, France; Pathogenesis; Pathogenicity; Pathway interactions; Patients; Peer Review; Physicians; Population; Positioning Attribute; Postdoctoral Fellow; Preclinical Testing; Prevalence; Probiotics; Production; Program Development; Proteomics; Publications; Published Comment; Recombinants; Relationship-Building; Reporting; Research; Research Personnel; Research Project Grants; Resolution; Risk Factors; Role; Science; Scientist; Seminal; Services; Students; Techniques; Technology; Textbooks; Toxin; Training; Translational Research; Underrepresented Minority; Universities; Veterans; Virulence; Vision; Work; acute care; antibiotic-associated diarrhea; antimicrobial; biobank; capsule; career; comorbidity; cost effective; design; diarrheal disease; doctoral student; early-career faculty; frontier; healthcare-associated infections; improved; infection rate; interdisciplinary collaboration; invention; member; military health system; military veteran; mortality; novel; pathogen; pre-clinical; product development; programs; prospective; recruit; synthetic biology; systems research; tool; undergraduate student; vaccine candidate

Current Research and Intellectual Property advancement in the laboratory focuses on bacterial infections that result (paradoxically) from the use of antibiotics. Our studies are performed under a One Health strategy that aims to expand interdisciplinary collaboration in diverse aspects of healthcare for humans and other animals. Our VA and University Affiliate teams are thus focused on elucidating pathogenic mechanisms in the anaerobic human and veterinary pathogen Clostridioides difficile, as well as the diarrheal disease organisms Enteropathogenic and Enterohemorrhagic E. coli. Ongoing studies include comprehensive epidemiological and mechanistic interrogation of C. difficile infection (CDI). Specifically, we have (1) prospective CDI surveillance in Southern Arizona VA and non-VA hospitals that has resulted in one of the only curated, fingerprinted and fully- cataloged C. difficile biorepositories in the Southwestern US; (2) developed precision genomics and proteomics approaches to identify factors contributing to the heightened virulence of newer strains of C. difficile; and (3) leveraged the information from (1) and (2) to develop multiple, novel C. difficile anti-infectives including targeted and bio-controlled live biotherapeutics as well as narrow-spectrum antimicrobials. Our VA Merit awards have resulted in one issued, and two Provisional, Patents as of December 2020. There are two over-arching goals of the activities described above. The first is to improve the health of Veterans and, indeed, the elderly and immunocompromised, by developing safe, oral, cost-effective anti-infective technologies that can transition expediently from the pre-clinical pipeline and into the community. The second is to continue to partner with VA, national and international Collaborators and train mentees such that current efforts can be channeled into a legacy plan for anti-infective research both at the SAVAHCS station as well as the University Affiliate. This renewal RCS application is thus envisaged as critical to the continued building of relationships within and outside the Southern Arizona VA Healthcare System community. Our research record underscores the power of cross-disciplinary science, and the RCS platform has enabled engagement with diverse research groups and fostered new avenues of investigation. Core values that have been cultivated via these collaborations include active listening, inclusive discussion and thoughtful communication. Training and Mentoring is an integral aspect of the PIs’ professional vision, and the current RCS cycle has provided opportunities to work with diverse and outstanding trainees and mentees. These have included (and continue to include) first-generation college students, members of under-represented minorities, early-career Faculty, and Physician-Scientist trainees. Taken together, RCS activities are envisioned to continue fostering focused and substantive contributions to the betterment of Veterans’ health via the development of products and technologies aimed at ameliorating healthcare-associated infections.

目前实验室的研究和知识产权进展主要集中在细菌感染上 （矛盾的是）我们的研究是在“同一个健康”策略下进行的。 旨在扩大人类和其他动物医疗保健各个方面的跨学科合作。 因此，我们的 VA 和大学附属团队致力于阐明厌氧菌的致病机制。 人类和兽医病原体艰难梭菌，以及腹泻病微生物 正在进行的肠致病性和肠出血性大肠杆菌研究包括全面的流行病学和 具体而言，我们对艰难梭菌感染 (CDI) 进行了 (1) 前瞻性 CDI 监测。 亚利桑那州南部 VA 和非 VA 医院是唯一经过精心策划、指纹识别和全面管理的医院之一 对美国西南部的艰难梭菌生物库进行了编目；(2) 开发了精密基因组学和蛋白质组学； 确定导致艰难梭菌新菌株毒力的因素的方法；以及 (3) 利用 (1) 和 (2) 中的信息开发多种新型艰难梭菌抗感染药物，包括靶向药物 和生物控制活生物治疗药物以及窄谱抗菌药物，我们获得了 VA 优异奖。 截至 2020 年 12 月，已获得一项已发布专利和两项临时专利。 上述活动有两个总体目标，第一个目标是改善退伍军人的健康。 事实上，通过开发安全、口服、具有成本效益的抗感染药物，可以帮助老年人和免疫功能低下的人 可以方便地从临床前管道过渡到社区的技术。 继续与 VA、国内和国际合作者合作并培训受训者，以便当前的努力 可以被纳入 SAVAHCS 站以及 大学附属机构。 因此，这一更新的 RCS 应用程序被认为对于持续建立内部和外部关系至关重要。 我们的研究记录强调了亚利桑那州南部 VA 医疗系统社区之外的力量。 跨学科科学，RCS 平台使不同的研究小组和 通过这些合作培养了新的调查途径。 积极倾听、包容性讨论和深思熟虑的沟通。 培训和指导是 PI 职业愿景的一个组成部分，当前的 RCS 周期已 提供与多元化和优秀的学员和学员一起工作的机会。 继续包括）第一代大学生、代表性不足的少数族裔成员、早期职业生涯 教师和医师科学家实习生。 总而言之，RCS 活动预计将继续促进对 通过开发旨在改善退伍军人健康的产品和技术来改善退伍军人的健康 医疗保健相关感染。