The synchrony study: A randomized controlled trial of music training for children with FASD

同步研究：针对 FASD 儿童的音乐训练的随机对照试验

基本信息

批准号：
10649003
负责人：
JULIA MARIE STEPHEN
金额：
$ 31.17万
依托单位：
LOVELACE BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-05 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10649003
关键词：
16 year old Academic skills Active Listening Address Adult Age Attention Auditory Auditory Perception Behavior Behavior Therapy Behavioral Blinded Brain Child Code Cognition Cognitive Complex Cross-Over Studies Crossover Design Diffusion Magnetic Resonance Imaging Disease Dose Educational Intervention Electroencephalography Environment Evidence based intervention Exhibits Family Fetal Alcohol Exposure Fetal Alcohol Spectrum Disorder Fetal alcohol effects Future High Prevalence Individual Intervention Lifestyle-related condition Longevity Magnetic Resonance Imaging Magnetoencephalography Measurable Measures Modeling Motor Motor Skills Music National Institute on Alcohol Abuse and Alcoholism Neuronal Plasticity Neuropsychology Outcome Outcome Assessment Outcome Measure Parents Participant Perception Performance Phase Pilot Projects Play Procedures Qualifying Quality of life Questionnaires Randomized Randomized, Controlled Trials Regulation Role Sampling Schools Sensory Short-Term Memory Strategic Planning Structure Structure of supramarginal gyrus Testing Time Training United States United States National Institutes of Health Visual Perception active control age effect age group auditory discrimination behavior measurement cognitive benefits cognitive function cognitive skill cognitive training efficacy evaluation emotion regulation executive function experience frontal lobe function improved improved outcome inattention indexing innovation instrument multidisciplinary multisensory neural neuroimaging neurophysiology primary outcome reduce symptoms response sensory integration skills sound trial comparing

项目摘要

Abstract Recent estimates indicate that, conservatively, up to 5% of children in the United States have sufficient behavioral and cognitive effects due to prenatal alcohol exposure that they qualify for a fetal alcohol spectrum disorder (FASD). Children with an FASD experience a range of effects, including deficits in sensory, motor, and executive functions, which are in turn related to poor long-term outcomes. However, few evidence-based interventions are available for children with an FASD and, of these, only two target academic or cognitive skills. Music training (MT) targets a complex array of skills including auditory and visual perception, multisensory integration, attention, and working memory. These MT targets align well with the deficits experienced by children with FASD and, therefore, MT may be well-suited for improving outcomes for these children. In this project, we hypothesize that MT improves brain function and targeted skills via improvement in predictive coding. The predictive coding framework posits that a primary role of the brain is to predict the environment and optimize outcomes through identifying and correcting prediction errors. MT provides direct practice of predictive coding when participants regularly produce sounds (environment) and adjust their behavior to correct any errors (fix incorrect notes/timing). We further posit that this bottom-up training will help optimize sensory, motor, and cognitive function relative to top-down strategies, leading to better outcomes. Our pilot MT intervention in children with an FASD provided exciting evidence for acceptance of MT by children and parents and for the occurrence of pre-/post-MT changes at the neural and behavioral level in children with MT vs. those without MT. In the R61 phase, we will conduct a randomized cross-over study of a 12-week MT intervention relative to a music listening (ML) control period in a larger sample to examine neurophysiological changes in predictive coding and behavioral effects due to MT in FASD in children 8-16 years of age. We will assess changes in 1) brain function using magnetoencephalography and electroencephalography, 2) brain structure using structural magnetic resonance imaging and diffusion tensor imaging, and 3) cognition and behavior using neuropsychological assessment and questionnaires at three time points (pre-trial (week 1), cross-over (week 13), and post-trial (week 28)). In the R33 phase, we will again implement a randomized cross-over design in 8-16 year-olds with an FASD to: a) compare MT effects relative to a cognitive training (CT) control and b) evaluate dose effects by comparing 12- vs. 24-weeks of intervention. We hypothesize that the bottom-up approach of MT, which improves sensory (auditory) and motor functioning, will lead to changes in brain connectivity, which in turn will improve cognitive functioning relative to the top- down approach of CT. We have assembled a strong multidisciplinary team to implement a music training intervention and assess the outcomes using objective neuroimaging, cognitive, and behavioral measures. Future studies will explore how MT can contribute to a strengths-based intervention approach for FASD.

抽象的最近的估计表明，在美国，多达5％的儿童有足够的儿童由于产前酒精暴露而导致的行为和认知作用，它们有资格获得胎儿酒精谱系障碍（FASD）。具有FASD的儿童经历了一系列效果，包括感觉，电动机的缺陷，和执行功能，这反过来又与长期不良结果有关。但是，很少有证据具有FASD的儿童可供干预，其中只有两个目标学术或认知技能。音乐培训（MT）针对一系列复杂的技能，包括听觉和视觉感知，多感官集成，注意力和工作记忆。这些MT目标与因此，患有FASD的孩子，因此MT可能非常适合改善这些孩子的结果。在这个项目，我们假设MT通过改善预测性来提高大脑功能和目标技能编码。预测编码框架认为大脑的主要作用是预测环境并通过识别和纠正预测错误来优化结果。 MT提供直接实践当参与者定期产生声音（环境）并将其行为调整为更正任何错误（修复了不正确的说明/计时）。我们进一步认为，这种自下而上的培训将有助于优化相对于自上而下的策略，感觉，运动和认知功能可带来更好的结果。我们对患有FASD的儿童的飞行员MT干预为接受MT接受MT提供了令人兴奋的证据儿童和父母，以及在神经和行为层面上发生前/MT的发生前/后发生变化有MT的孩子与没有MT的孩子。在R61阶段，我们将对A进行随机交叉研究在较大样本中，相对于音乐听力（ML）控制期的12周MT干预以检查在FASD中，儿童MT引起的预测性编码和行为影响的神经生理学变化8-16 年龄。我们将评估1）使用磁脑电图和大脑功能的变化脑电图，2）使用结构磁共振成像和扩散张量的大脑结构成像，以及3）三次使用神经心理学评估和问卷调查的认知和行为积分（预审（第1周），交叉（第13周）和审判后（第28周））。在R33阶段，我们将再次在8-16岁的FASD中实施随机跨界设计进行认知训练（CT）控制和B）通过比较12-24周的干预措施来评估剂量效应。我们假设MT的自下而上的方法可以改善感觉（听觉）和电动机功能，将导致大脑连通性的变化，这反过来将改善相对于顶部的认知功能 CT的下降方法。我们已经组建了一个强大的多学科团队来实施音乐培训干预并使用客观神经影像，认知和行为措施评估结果。未来的研究将探讨MT如何为FASD的基于优势的干预方法做出贡献。