Preterm Infants' Mu-rhythm Suppression Evaluation Study (PrIMES)

早产儿多节律抑制评估研究（PriIMES）

• 批准号: 8427274
• 负责人: JULIA MARIE STEPHEN
• 金额: $ 19.58万
• 依托单位: THE MIND RESEARCH NETWORK
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8427274
• 关键词: Age; Area; Brain; Characteristics; Child; Clinical; Cognitive; Deformity; Development; Early Intervention; Effectiveness; Electroencephalography; Emotions; Evaluation Studies; Frequencies; Gestational Age; Goals; Hand; Impaired cognition; Impairment; Incidence; Infant; Infant Development; Instruction; Intervention; Lead; Learning; Lesion; Link; Literature; Longitudinal Studies; Low Birth Weight Infant; Magnetic Resonance Imaging; Magnetoencephalography; Measures; Methods; Mind; Mission; Monitor; Motor; Motor Activity; Movement; Neonatal; Outcome; Participant; Periventricular Leukomalacia; Play; Premature Birth; Premature Infant; Public Health; Publishing; Relative (related person); Reporting; Research; Research Personnel; Rest; Risk; Risk Factors; Role; Sensory; Sleep; Techniques; Testing; Time; Translating; Ultrasonography; United States National Institutes of Health; Very Low Birth Weight Infant; base; cognitive function; experience; follow-up; high risk; improved; innovation; intraventricular hemorrhage; mirror neuron system; neuroimaging; neuron development; novel; postnatal; premature; response; skills; standardize measure; theories; Age; Area; Brain; Characteristics; Child; Clinical; Cognitive; Deformity; Development; Early Intervention; Effectiveness; Electroencephalography; Emotions; Evaluation Studies; Frequencies; Gestational Age; Goals; Hand; Impaired cognition; Impairment; Incidence; Infant; Infant Development; Instruction; Intervention; Lead; Learning; Lesion; Link; Literature; Longitudinal Studies; Low Birth Weight Infant; Magnetic Resonance Imaging; Magnetoencephalography; Measures; Methods; Mind; Mission; Monitor; Motor; Motor Activity; Movement; Neonatal; Outcome; Participant; Periventricular Leukomalacia; Play; Premature Birth; Premature Infant; Public Health; Publishing; Relative (related person); Reporting; Research; Research Personnel; Rest; Risk; Risk Factors; Role; Sensory; Sleep; Techniques; Testing; Time; Translating; Ultrasonography; United States National Institutes of Health; Very Low Birth Weight Infant; base; cognitive function; experience; follow-up; high risk; improved; innovation; intraventricular hemorrhage; mirror neuron system; neuroimaging; neuron development; novel; postnatal; premature; response; skills; standardize measure; theories

DESCRIPTION (provided by applicant): Prematurity as a risk factor for long-term cognitive impairment is increasingly important, as the rate of prematurity has risen and infants are surviving at progressively lower gestational ages. Although anatomical abnormalities, identified with ultrasound and MRI, have been shown to lead to poor long-term outcomes, it is not clear why infants with an uncomplicated course and no brain lesions after premature birth are still at higher risk for cognitive impairment relative to infants born at term, and conversely why some infants with brain lesions do not suffer from impaired abilities. Therefore, the long-term goal is o identify a complimentary set of functional brain markers to help clinicians recognize which infants will need additional intervention to achieve improved outcomes. Sensorimotor mu rhythm activity has been associated with a cortical network which is important for imitation skills, understanding other's intentions, and additional theory of mind abilities. The objective of the current project is to characterize the sensorimotor mu rhythm and mu rhythm suppression in preterm relative to term infants longitudinally, at 3 and 6 months adjusted age. The central hypothesis is that infants with atypical brain development will present with impaired sensorimotor mu rhythm development and these delays will correspond with impaired cognitive development. This hypothesis was developed based on literature demonstrating motor delays and anatomical abnormalities in the sensorimotor region in prematurely born infants. Furthermore, our published results provide evidence for a rapid progression of the frequency of the mu rhythm at very young ages providing a measure to track brain development. This hypothesis will be tested through the following specific aim: To characterize and compare the development of the mu rhythm associated with motor activity in young infants at 3 and 6 months corrected-age in two participant groups: a) healthy full-term infants and b) premature infants (<28 weeks gestational age) without evidence of brain abnormalities or lesions. This project will use simultaneous magnetoencephalography (MEG) and electroencephalography (EEG), to monitor spontaneous mu rhythm activity and mu rhythm suppression using three conditions: rest, infant hand squeeze, and infant observation of investigator hand squeeze. The preliminary results provide evidence that this paradigm can be performed quickly and without the need for infants to understand task instruction. Comparison of the three conditions allows one to: a) identify the frequency of mu rhythm activity; and b) quantify mu rhythm suppression in the action (squeeze) and observation conditions. This approach is innovative because we are using a multimodal functional neuroimaging approach, drawing on the strengths of each technique, to test a novel paradigm for preterm infants, which has been linked to imitation and higher cognitive abilities. This project is significant because it will evaluate a characteristic of the preterm brain that develops rapidly in term infants, providing a potential marker of atypical brain development in preterm infants, to help identify children in need of early intervention.

描述（由申请人提供）：早产作为长期认知障碍的危险因素越来越重要，因为早产速度的上升速度已经上升，婴儿在逐渐较低的妊娠年龄中生存。尽管已证明具有超声和MRI的解剖异常已导致长期结局不佳，但尚不清楚为什么过早出生后没有简单的病例并且没有脑部病变的婴儿仍然对相对于婴儿出生的婴儿的认知障碍风险较高，而对某些婴儿出生的婴儿的患者的身份不受脑膜的影响，为什么有些人会遭受Absimaigair abimair abimair abimair abimair abiage abiair absiage abimair absimage。因此，长期目标是o确定一套免费的功能性脑标记，以帮助临床医生认识到哪些婴儿需要额外的干预才能提高预后。感觉运动MU节奏活动与皮质网络有关，这对于模仿技能，理解他人的意图和其他心理能力理论很重要。当前项目的目的是表征早产的感觉运动MU节奏和MU节律抑制，相对于纵向婴儿，在3个月和6个月调整后的年龄。中心假设是，具有非典型大脑发育的婴儿将出现感官MU节律发育受损，这些延迟将与认知发展受损相对应。该假设是基于文献，该文献证明了早产婴儿的感觉运动区域的运动延迟和解剖异常。此外，我们发表的结果提供了证据表明，很年轻的MU节奏频率的快速发展提供了跟踪脑发育的措施。该假设将通过以下具体目的进行检验：在两个参与者组中，在3和6个月校正时期与年轻婴儿的运动活动相关的MU节奏的发展和比较：a）健康的完整婴儿和b）早产儿（<28周<28周的Gestational Gestational年龄），而没有脑部异常或脑部异常的证据。该项目将使用同时使用磁脑电图（MEG）和脑电图（EEG）来监测自发的MU节律活性和使用三个条件：休息，婴儿手动挤压和婴儿手动挤压的婴儿观察。初步结果提供了证据，表明可以快速执行此范式，而无需婴儿以了解任务指令。这三个条件的比较允许一个：a）确定MU节奏活性的频率； b）在动作（挤压）和观察条件下量化MU节奏抑制。这种方法具有创新性，因为我们使用的是一种多模式功能性神经影像学方法，借鉴了每种技术的优势，以测试早产儿的新型范式，该方法与模仿和更高的认知能力有关。该项目很重要，因为它将评估早产大脑的特征，该特征在学期婴儿中迅速发展，从而提供了非典型大脑的潜在标志 早产儿的发展，以帮助确定需要早期干预的儿童。