Multimodal Data Acquisition (MDA) Core

多模式数据采集 (MDA) 核心

基本信息

批准号：
9281578
负责人：
JULIA MARIE STEPHEN
金额：
$ 32.7万
依托单位：
THE MIND RESEARCH NETWORK
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-18 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9281578
关键词：
Algorithmic Analysis Biomedical Engineering Biometry Blood Brain Centers of Research Excellence Clinical Clinical Research Clinical assessments Communication Data Data Analyses Data Quality Development Devices Diffusion Diffusion Magnetic Resonance Imaging Dimensions Disease Education Electroencephalography Ensure Equilibrium Equipment Excision Fiber Functional Magnetic Resonance Imaging Funding Future Growth Human Resources Image Impaired cognition Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Magnetoencephalography Maintenance Maps Measurement Measures Mentors Methods Monitor Mood Disorders Morphologic artifacts Motion Multimodal Imaging Myelin Neurology Neurons Noise Phase Physics Physiologic Monitoring Physiological Pilot Projects Principal Investigator Protocols documentation Research Personnel Resolution Resources Role Series Stimulus Structure System Techniques Testing Tissues Training base data acquisition design experience experimental study gamma-Aminobutyric Acid imaging capabilities improved innovation interest investigator training lectures meetings metabolic profile method development multimodality neurochemistry neuroimaging neuroinformatics neurophysiology neuropsychiatric disorder neuropsychiatry novel quality assurance radio frequency rapid growth response temporal measurement tool white matter

项目摘要

Project Summary/Abstract The Phase III multimodal data acquisition (MDA) core provides: 1) state-of-the-art neuroimaging protocols for stable and reliable imaging; 2) training of principal investigators (PIs) and their support staff on general and practical aspects of acquiring neuroimaging data (e.g., physics of imaging, how to avoid and correct for motion artifacts); and 3) new technological development to answer questions that will lead to new core capabilities and help future users of the MDA core. Specifically, the MDA core will support neuroimaging protocols based on magnetic resonance imaging (MRI), magnetoencephalography (MEG) and electroencephalography (EEG). These protocols include high resolution structural MRI (sMRI), diffusion MRI (dMRI) to map fiber connectivity, functional MRI (fMRI) to characterize changes in blood oxygenation as a consequence of neuronal activation, MEG/EEG to directly monitor neuronal activation with high temporal resolution, and MR spectroscopy (MRS) to measure brain metabolic profiles. The emphasis is on multimodal imaging so each Project PI will acquire imaging data from some combination of the above including concurrent EEG-fMRI or MEG-EEG. Training of PIs and support personnel consists primarily of lectures embedded within weekly meetings and a formal monthly seminar series managed by the administrative, clinical assessment, and mentoring (ADM) core. New MRI protocols will be developed during Phase III that take full advantage of the 32-channel radio-frequency (RF) coil now available at MRN. New developments include: 1) examining white matter integrity (myelin maps and structural connectiv- ity); 2) attaining higher temporal resolution in concurrent EEG-fMRI experiments for studying dynamic changes in functional connectivity; 3) developing optimal methods for removal of physiological noise; and 4) optimizing three-dimensional GABA measurement methods to enable reliable measurements over smaller voxels. This core is led by Dr. Julia Stephen (MRN) with over 20 years of experience in MEG/EEG methods, along with MR phys- icists Drs. Arvind Caprihan (MRN) and Stefan Posse (UNM Neurology) who each have 20+ years of experience with MR-based methods. Drs. Larry Wald (MGH) and Matthew Brookes (Univ. Nottingham) are consultants on this core. 2

项目概要/摘要 III 期多模式数据采集 (MDA) 核心提供：1) 最先进的神经影像协议成像稳定可靠； 2) 对主要研究者 (PI) 及其支持人员进行一般性和获取神经影像数据的实际方面（例如，成像物理学、如何避免和纠正运动）文物）； 3）新技术的发展来回答将带来新的核心能力的问题帮助 MDA 核心的未来用户。具体来说，MDA 核心将支持基于磁共振成像（MRI）、脑磁图（MEG）和脑电图（EEG）。这些协议包括高分辨率结构 MRI (sMRI)、用于映射光纤连接的扩散 MRI (dMRI)、功能性 MRI (fMRI) 可表征神经元激活导致的血氧变化， MEG/EEG 以高时间分辨率直接监测神经元激活，而 MR 波谱 (MRS) 则可测量大脑代谢概况。重点是多模态成像，因此每个项目 PI 将获取成像来自上述某些组合的数据，包括并发 EEG-fMRI 或 MEG-EEG。 PI 的培训和支持人员主要包括每周会议中的讲座和每月一次的正式研讨会系列由行政、临床评估和指导 (ADM) 核心管理。新的 MRI 协议将将在第三阶段开发，充分利用现有的 32 通道射频 (RF) 线圈在 MRN。新进展包括：1）检查白质完整性（髓磷脂图和结构连接）性）; 2）在并发脑电图-功能磁共振成像实验中获得更高的时间分辨率以研究动态变化在功能连接方面； 3）开发消除生理噪声的最佳方法； 4）优化三维 GABA 测量方法可实现对较小体素的可靠测量。这个核心由 Julia Stephen 博士 (MRN) 领导，他在 MEG/EEG 方法以及 MR phys 方面拥有 20 多年的经验 icists 博士。 Arvind Caprihan (MRN) 和 Stefan Posse (UNM 神经病学) 均拥有 20 多年的经验使用基于 MR 的方法。博士。拉里·沃尔德（麻省总医院）和马修·布鲁克斯（诺丁汉大学）是以下方面的顾问：这个核心。 2