Multimodal Data Acquisition (MDA) Core

多模式数据采集 (MDA) 核心

基本信息

批准号：
9281578
负责人：
JULIA MARIE STEPHEN
金额：
$ 32.7万
依托单位：
THE MIND RESEARCH NETWORK
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-18 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9281578
关键词：
Algorithmic Analysis Biomedical Engineering Biometry Blood Brain Centers of Research Excellence Clinical Clinical Research Clinical assessments Communication Data Data Analyses Data Quality Development Devices Diffusion Diffusion Magnetic Resonance Imaging Dimensions Disease Education Electroencephalography Ensure Equilibrium Equipment Excision Fiber Functional Magnetic Resonance Imaging Funding Future Growth Human Resources Image Impaired cognition Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Magnetoencephalography Maintenance Maps Measurement Measures Mentors Methods Monitor Mood Disorders Morphologic artifacts Motion Multimodal Imaging Myelin Neurology Neurons Noise Phase Physics Physiologic Monitoring Physiological Pilot Projects Principal Investigator Protocols documentation Research Personnel Resolution Resources Role Series Stimulus Structure System Techniques Testing Tissues Training base data acquisition design experience experimental study gamma-Aminobutyric Acid imaging capabilities improved innovation interest investigator training lectures meetings metabolic profile method development multimodality neurochemistry neuroimaging neuroinformatics neurophysiology neuropsychiatric disorder neuropsychiatry novel quality assurance radio frequency rapid growth response temporal measurement tool white matter

项目摘要

Project Summary/Abstract The Phase III multimodal data acquisition (MDA) core provides: 1) state-of-the-art neuroimaging protocols for stable and reliable imaging; 2) training of principal investigators (PIs) and their support staff on general and practical aspects of acquiring neuroimaging data (e.g., physics of imaging, how to avoid and correct for motion artifacts); and 3) new technological development to answer questions that will lead to new core capabilities and help future users of the MDA core. Specifically, the MDA core will support neuroimaging protocols based on magnetic resonance imaging (MRI), magnetoencephalography (MEG) and electroencephalography (EEG). These protocols include high resolution structural MRI (sMRI), diffusion MRI (dMRI) to map fiber connectivity, functional MRI (fMRI) to characterize changes in blood oxygenation as a consequence of neuronal activation, MEG/EEG to directly monitor neuronal activation with high temporal resolution, and MR spectroscopy (MRS) to measure brain metabolic profiles. The emphasis is on multimodal imaging so each Project PI will acquire imaging data from some combination of the above including concurrent EEG-fMRI or MEG-EEG. Training of PIs and support personnel consists primarily of lectures embedded within weekly meetings and a formal monthly seminar series managed by the administrative, clinical assessment, and mentoring (ADM) core. New MRI protocols will be developed during Phase III that take full advantage of the 32-channel radio-frequency (RF) coil now available at MRN. New developments include: 1) examining white matter integrity (myelin maps and structural connectiv- ity); 2) attaining higher temporal resolution in concurrent EEG-fMRI experiments for studying dynamic changes in functional connectivity; 3) developing optimal methods for removal of physiological noise; and 4) optimizing three-dimensional GABA measurement methods to enable reliable measurements over smaller voxels. This core is led by Dr. Julia Stephen (MRN) with over 20 years of experience in MEG/EEG methods, along with MR phys- icists Drs. Arvind Caprihan (MRN) and Stefan Posse (UNM Neurology) who each have 20+ years of experience with MR-based methods. Drs. Larry Wald (MGH) and Matthew Brookes (Univ. Nottingham) are consultants on this core. 2

项目摘要/摘要 III阶段多模式数据采集（MDA）核心提供：1）最新的神经影像协议用于稳定可靠的成像； 2）对总体调查人员（PIS）培训一般和支持人员获取神经影像数据的实际方面（例如，成像的物理学，如何避免和纠正运动文物）; 3）回答将导致新核心功能的问题的新技术发展和帮助MDA核心的未来用户。具体而言，MDA核心将基于磁共振成像（MRI），磁性摄影（MEG）和脑电图（EEG）。这些方案包括高分辨率结构MRI（SMRI），扩散MRI（DMRI）以绘制纤维连接性，功能性MRI（fMRI）表征由于神经元激活而导致血液氧合的变化， MEG/EEG直接以高时间分辨率监测神经元激活，MR光谱法（MRS）至测量大脑代谢谱。重点是多模式成像，因此每个项目PI都会获取成像来自上述某种组合的数据，包括并发的EEG-FMRI或MEG-EEG。培训PI和支持人员主要由每周会议中嵌入的讲座和正式的每月研讨会组成由行政，临床评估和指导（ADM）核心管理的系列。新的MRI协议将可以在第三阶段中开发，以充分利用32通道射频（RF）线圈在MRN。新的发展包括：1）检查白质完整性（髓磷脂图和结构连接 - 性）; 2）在研究动态变化的并发EEG-FMRI实验中达到较高的时间分辨率在功能连接中； 3）开发去除生理噪声的最佳方法； 4）优化三维GABA测量方法可在较小的体素上实现可靠的测量。这个核心由朱莉娅·斯蒂芬（Julia Stephen）博士（MRN）领导，拥有超过20年的MEG/EEG方法经验，以及Phys-Phys- 伊斯特博士。 Arvind Caprihan（MRN）和Stefan Posse（UNM神经病学）都有20年以上的经验使用基于M的方法。博士。拉里·瓦尔德（MGH）和马修·布鲁克斯（MATTHEW BROOKES）（诺丁汉大学）是这个核心。 2