Following the Sound of Music - Comparing the Effects of Music vs. Non-Music Based Interventions on Auditory and Cognitive Processing in Older Adults

跟随音乐之声 - 比较音乐与非音乐干预对老年人听觉和认知处理的影响

• 批准号: 10273909
• 负责人: Susanne M Jaeggi
• 金额: $ 53.62万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10273909
• 关键词: Active Listening; Address; Age-associated memory impairment; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Apple; Attention; Auditory; Automobile Driving; Brain; Clinical Trials; Cognition; Cognitive; Cognitive aging; Collaborations; Communication; Data; Development; Dose; Effectiveness; Elderly; Environment; Frustration; Future; Goals; Health; Home; Impaired cognition; Individual; Intervention; Knowledge; Lead; Long-Term Effects; Measures; Mediating; Memory; Mission; Moods; Music; National Institute of Drug Abuse; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; National Institute on Alcohol Abuse and Alcoholism; Outcome; Outcome Measure; Outpatients; Performance; Personal Satisfaction; Phase; Population; Presbycusis; Prevention; Process; Psyche structure; Public Health; Quality of life; Randomized Controlled Trials; Reporting; Research; Resources; Risk; Short-Term Memory; Social Interaction; Social isolation; Speech; Stimulus; Target Populations; Taxes; Testing; Training; United States National Institutes of Health; Well in self; Work; acceptability and feasibility; active control; age effect; age related; arm; auditory processing; base; cognitive ability; cognitive function; cognitive process; cognitive skill; cost effective; cost effective intervention; disability burden; evidence base; experience; feasibility testing; fitness; follow up assessment; functional independence; hearing impairment; human old age (65+); implementation intervention; improved; innovation; instrument; mood regulation; multidisciplinary; musician; novel; preservation; programs; prototype; psychologic; response; secondary outcome; skills; sound; usability

PROJECT SUMMARY The overall objective of the proposed work is to test the benefits of a music-based intervention on speech-in- competition abilities in an older adult population that includes individuals that may be at risk of Alzheimer's disease and related dementias (ADRD). Age-related hearing difficulties are prevalent, with speech-in- competition difficulties being a common challenge amongst older adults. Critically, these difficulties and frustrations often lead to social isolation and decreased cognitive engagement, and they are associated with an increased risk of developing ADRD. There is evidence suggesting that musical training is associated with cognitive advantages in older adults, including preserved ability for speech-in-competition. However, to date, there is extremely limited knowledge and lack of experimental evidence explaining how music might benefit speech-in-competition abilities, along with more basic auditory processes and/or cognitive functions. We aim to contribute to uncovering the underlying mechanisms driving the potential effects of music and attention through an innovative, attention-based music listening intervention that cultivates auditory and attentional skills akin to those developed during formal instrumental training. To disentangle potential effects of music and attention and to get at the underlying mechanisms of music effects, we will compare outcomes of this attention-based music intervention with those of two active control interventions that consist of either passive music listening or active listening to non-music sounds. Specific aims are to develop and test the feasibility of music and control interventions and assessments targeting auditory processing and cognition (R61; Aim 1); test for intervention- specific improvements in speech-in-competition using a randomized-controlled trial (R33; Aim 2); and determine whether experimental and control interventions differentially impact measures of auditory processing, memory, and attention, and test how these may mediate performance on measures of speech-in-competition (R33; Aim 3). Long-term objectives are to understand the key mechanisms underlying the benefits of music with the overall goal to inform interventions aimed at mitigating the effects of ADRD. This proposal is transformative in that it utilizes an innovative approach to uncover potential benefits and underlying mechanisms of music by testing the added benefits of interventions and testing their benefits against a broad set of outcomes measures that can be used to further understand the malleability of auditory processes and cognition in aging. In addition, the intervention is cost-effective, easily administrable, and accessible to individuals who may not possess the physical capabilities or resources that formal instrumental practice demands. In addition, music has been shown to provide other benefits including mood regulation and psychological well-being, and as such, the intervention may have benefits that go beyond the auditory or cognitive domain. Overall, the proposed work aims to contribute to the amelioration and/or prevention of cognitive decline in individuals that may be at risk for developing ADRD.

项目摘要 拟议工作的总体目的是测试基于音乐的干预对语音中的干预的好处 老年人的竞争能力包括可能有阿尔茨海默氏症风险的人 疾病和相关痴呆症（ADRD）。与年龄相关的听力困难很普遍，语音中 竞争困难是老年人的普遍挑战。至关重要的是，这些困难和 挫败感通常会导致社会孤立和认知能力下降，它们与 增加了ADRD的风险。有证据表明音乐训练与 老年人的认知优势，包括保留竞争的能力。但是，迄今为止， 知识非常有限，缺乏实验证据，以解释音乐如何受益 竞争能力，以及更基本的听觉过程和/或认知功能。我们的目标 有助于发现通过 一种创新的，基于注意力的音乐听力干预措施，培养听觉和注意力技巧类似 那些在正式的乐器培训中开发的。消除音乐和关注的潜在影响， 要了解音乐效果的基本机制，我们将比较这种基于注意的音乐的结果 干预两种主动控制干预措施的干预措施包括被动音乐或活动 听非音乐的声音。具体目的是发展和测试音乐和控制的可行性 针对听觉处理和认知的干预和评估（R61； AIM 1）；测试干预 - 使用随机控制试验（R33; AIM 2）在竞争中的特定改进；并确定 实验和控制干预措施是否会差异地影响听觉处理，记忆， 和注意，并测试这些如何介导竞争措施的表现（R33； AIM 3）。长期目标是了解音乐带有整体益处的关键机制 旨在减轻ADRD影响的干预措施的目标。该提议具有变革性 利用一种创新的方法通过测试 干预措施的添加好处并根据一系列可能是的结果措施测试其收益 用于进一步了解听觉过程和衰老认知的锻造性。另外， 干预是具有成本效益，易于管理的，并且可能不具备的个人可以访问 正式练习需要的物理能力或资源。此外，已经显示了音乐 提供其他好处，包括情绪调节和心理健康，因此，干预 可能具有超出听觉或认知领域的好处。总体而言，拟议的工作旨在做出贡献 为了改善和/或预防可能有发展ADRD风险的个体认知能力下降。