Training in Pharmacological Sciences

药理学培训

• 批准号: 10612401
• 负责人: DAVID E. GOLAN
• 金额: $ 41.34万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10612401
• 关键词: Science; Training; pharmacologic

Project Abstract: We seek eight training slots to support students during their first and/or second year of training in pharmacological sciences. The Therapeutics Graduate Program (TGP) recruits students from multiple Harvard PhD programs to build a diverse and inclusive community focused on therapeutic science, with a strong focus on professional skills development and career mentoring. The TGP provides rigorous training in the science of drug discovery, evaluation, and clinical use through a required core curriculum, paracurricular activities focused on professional skills development, and a signature required internship, where students spend 2–4 months in an industrial or regulatory science setting before the end of their 4th year. Recruitment: The TGP will recruit students and faculty from multiple HMS and Harvard programs, including Biological and Biomedical Sciences (BBS), Chemical Biology, and Systems Biology graduate programs at Harvard Medical School (HMS), Harvard University, and the HMS-affiliated teaching hospitals. Faculty will be evaluated for scientific relevance and mentoring skills, and openness to student-centric training experiences. Diversity/inclusion: We are committed to building a diverse, inclusive, and supportive training community. Intellectual diversity will benefit by recruitment from multiple PhD programs. We will boost social and ethnic diversity by emphasizing how the TGP prepares students for careers with direct societal impact and provides clear and direct career preparation through internships. Professional skills and career development: We involve industry professionals in teaching 1st year classes and co-organizing paracurricular activities focused on skills development. Our required internship experience provides trainees with hands-on exposure to industrial or regulatory science work environments, and provides strong networking opportunities. Internships also help mentors understand the benefit of our commitment to student-centric training. Scientific rigor and responsible conduct: These components are emphasized throughout the curriculum, and reinforced by mentorships where students are exposed to team-based science in a professional setting. Training benefit: There is a strong demand for PhD-level scientists who have been rigorously trained in the core concepts of drug discovery. Demographic trends are increasing the need for drug treatments, and there is optimism for treating the most feared diseases based on recent progress and emergence of new drug modalities such as antibodies and oligonucleotides. Many research schools and hospitals are building translational research centers, often in collaboration with local industry, and these need to recruit faculty and PhD-level staff. The pharma/biotech industry has exploded in Massachusetts in the last decade, and many PhD-level positions remain unfilled. TGP trainees will lead in this growing field.

项目摘要： 我们寻求八个培训插槽，以支持学生在他们的第一年和/或第二年的培训中 药理学科学。 Therapeutics研究生课程（TGP）报告了来自多个哈佛大学的学生 博士计划建立一个专注于热科学的多元化和包容性社区，重点很重 关于专业技能发展和职业指导。 TGP在科学方面提供了严格的培训 通过所需的核心课程，旁课活动的药物发现，评估和临床使用 专注于专业技能发展和签名所需的实习，学生花费2-4 在第四年结束前的工业或监管科学环境中的几个月。招聘：TGP 将招募多个HM和哈佛计划的学生和教职员工，包括生物学和生物医学 哈佛医学院的科学（BBS），化学生物学和系统生物学研究生课程 （HMS），哈佛大学和HMS附属教学医院。教师将进行科学评估 相关性和指导能力，以及以学生为中心的培训经验的开放性。多样性/包容性：我们 智力多样性将致力于建立多样性，包容和支持性培训社区。 从多个博士学位课程中招募受益。我们将通过强调社会和种族多样性来促进社会和种族多样性 TGP如何为学生做好直接影响的职业准备，并提供清晰而直接的职业 通过实习做准备。专业技能和职业发展：我们参与行业 教学第一年课程的专业人士和共同组织的校园活动集中在技能上 发展。我们所需的实习经验为培训提供了动手实践的工业或 监管科学工作环境，并提供强大的网络机会。实习也有帮助 导师了解我们对以学生为中心培训的承诺的好处。科学严谨和 负责任的行为：这些组件在整个课程中都得到了强调，并加强了 在专业环境中，学生会接触到基于团队的科学的遗产。培训好处： 对博士学位的科学家的需求很大 药物发现。人口趋势正在增加对药物治疗的需求，并且对 基于最近的进展和新药物形式的出现（例如 抗体和寡核苷酸。许多研究学校和医院正在建立转化研究 中心通常与当地工业合作，这些中心需要招募教职员工和博士学位的员工。 在过去的十年中，Pharma/Biotech行业在马萨诸塞州进行了探索 保持毫无用处。 TGP学员将领导这个成长的领域。

项目成果

Base Editor Scanning Reveals Activating Mutations of DNMT3A.

• DOI: 10.1021/acschembio.3c00257
• 发表时间: 2023-09-15
• 期刊: ACS CHEMICAL BIOLOGY
• 影响因子: 4
• 作者: Garcia, Emma M.;Lue, Nicholas Z.;Liang, Jessica K.;Lieberman, Whitney K.;Hwang, Derek D.;Woods, James C.;Liau, Brian B.
• 通讯作者: Liau, Brian B.

An in silico method to assess antibody fragment polyreactivity.

• DOI: 10.1038/s41467-022-35276-4
• 发表时间: 2022-12-07
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Harvey, Edward P.;Shin, Jung-Eun;Skiba, Meredith A.;Nemeth, Genevieve R.;Hurley, Joseph D.;Wellner, Alon;Shaw, Ada Y.;Miranda, Victor G.;Min, Joseph K.;Liu, Chang C.;Marks, Debora S.;Kruse, Andrew C.
• 通讯作者: Kruse, Andrew C.