Sleep, Brain Development, and Behavioral Correlates in a Longitudinal Cohort of Children at Risk for ASD

患有自闭症谱系障碍 (ASD) 风险儿童纵向队列的睡眠、大脑发育和行为相关性

• 批准号: 10612375
• 负责人: Annette Estes
• 金额: $ 63.7万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-03 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612375
• 关键词: 10 year old; Accounting; Affect; Affective; Age Months; Anxiety; Autism Diagnosis; Beds; Behavior; Behavior Disorders; Behavior assessment; Behavioral; Biological; Brain; Brain imaging; Cerebrospinal Fluid; Characteristics; Child; Childhood; Circadian Dysregulation; Clinical; Cognition; Cognitive; Communication; Data; Development; Diagnosis; Disease; Environment; Family history of; Follow-Up Studies; Foundations; Funding; Goals; Growth; Health; Hippocampus; Home; Individual; Infant; Intervention; Light; Link; Literature; Longitudinal cohort; Magnetic Resonance Imaging; Maintenance; Medical; Mental disorders; Modeling; Moods; Nature; Neurobiology; Outcome; Parents; Pathogenesis; Pattern; Phenotype; Population; Prevalence; Problem behavior; Public Health; Reporting; Research; Research Priority; Risk; Sampling; Schedule; School-Age Population; Severities; Siblings; Sleep; Sleep Deprivation; Sleep Disorders; Strategic Planning; Structure; Symptoms; Temperature; Testing; United States National Institutes of Health; Vulnerable Populations; actigraphy; adverse outcome; affective disturbance; autism spectrum disorder; autistic children; biopsychosocial; circadian; cohort; comorbidity; design; developmental disease; diaries; early childhood; endophenotype; executive function; follow-up; imaging study; improved outcome; improvement on sleep; infancy; multimodality; neural; neural correlate; novel; psychiatric comorbidity; sleep health; sound; vigilance

Project Summary Children with autism spectrum disorder (ASD) are 2-3 times more likely to suffer from sleep problems than typically developing children. Despite being a high priority population for sleep research, and despite evidence that sleep problems have pervasive negative consequences for health, behavior, mood, and cognition, the increased occurrence and clinical impact of sleep problems in individuals with a family history of ASD is not well understood. This major public health concern is the focus of our application, “Sleep, Brain Development, and Behavioral Correlates in a Longitudinal Cohort of Children at Risk for ASD”. Problems with sleep initiation, circadian timing, and inadequate amount of sleep in a high familial risk (HR) cohort of school-age children are hypothesized to be preceded by altered brain and behavioral development in early childhood. This proposal leverages a recently funded longitudinal follow-up of 7-10 year-old HR children and children with low familial risk for ASD (LR) who have had multiple MRI and behavior assessments since infancy through the NIH Autism Center of Excellence Infant Brain Imaging Study (IBIS). This sample of 300 HR children includes ~100 diagnosed with ASD at 24 months, ~200 without a diagnosis of ASD but with outcomes ranging from typical development to developmental and psychiatric disorders known to occur at high rates in siblings of children with ASD, and 100 LR children currently returning for assessment, including MRI, during school age. A biopsychosocial model of pediatric sleep problems predicts that some combination of biological, environmental, behavioral and psychiatric factors will account for the increased prevalence of sleep problems in ASD, but it is unknown whether sleep problems are familial, endophenotypic, or disorder-specific in this population. We propose to: (1) characterize circadian disturbances, sleep duration, and other sleep parameters in the home using actigraphy, validated by sleep diary, and through parent report of behavioral and medical sleep problems, (2) examine brain growth trajectories (from infancy) associated with sleep problems in school-age, and (3) examine the longitudinal behavioral and developmental trajectories and concurrent behavior associated with sleep problems in school-age. Increased understanding of the neurobiology and developmental characteristics of sleep problems in ASD has important implications for developing novel, developmentally-sensitive sleep interventions which may help to reduce behavioral and health problems exacerbated by sleep problems and improve outcomes in this vulnerable population.

项目摘要 自闭症谱系障碍（ASD）的儿童患睡眠的可能性高2-3倍 问题比通常成长的儿童。尽管睡眠的优先人口很高 研究以及目的地证据表明睡眠问题对 健康，行为，情绪和认知，睡眠的发生和临床影响增加 患有ASD家族史的人的问题尚不清楚。这个主要的公共卫生 关注的是我们应用的重点，“睡眠，大脑发育和行为与行为相关 纵向有ASD风险的儿童纵向。 在高家族风险（HR）的学龄儿童中，睡眠不足是 假设在幼儿期之前，大脑和行为发展改变了。 该提议利用了最近资助的7-10岁的人力资源儿童的纵向随访和 患有多次MRI和行为评估的ASD家庭风险低的儿童 自从NIH自闭症卓越中心婴儿脑成像研究（IBIS）以来。这 300小时儿童的样本包括〜100个诊断为24个月的ASD，〜200，没有a 诊断ASD，但结果从典型发展到发展和 心理疾病已知在ASD儿童的兄弟姐妹和100 LR的兄弟姐妹中以高率发生 目前在学龄期间返回评估的儿童，包括MRI。生物心理社会 小儿睡眠问题的模型预测，生物，环境， 行为和精神病因素将解释睡眠问题的患病率增加 ASD，但尚不清楚睡眠问题是家庭，内植物典型或特定疾病 在这个人群中。我们建议：（1）表征昼夜节律，睡眠持续时间和 使用Actiography在家中的其他睡眠参数，通过睡眠日记验证，并通过父母验证 行为和医学睡眠问题的报告，（2）检查脑生长轨迹（来自 婴儿期）与学龄的睡眠问题有关，（3）检查纵向 行为和发育轨迹以及与睡眠相关的同时行为 学龄的问题。对神经生物学和发展的了解增加 ASD中睡眠问题的特征对发展新颖， 对发育敏感的睡眠干预措施可能有助于减少行为和健康 睡眠问题加剧了问题，并改善了这一脆弱人群的结局。