3/3; Promoting resilience in children:Protocol Development for a Birth Cohort Study to Access Factors Impacting Neurodevelopment

3/3；

• 批准号: 9900395
• 负责人: ANDREW L ALEXANDER
• 金额: $ 26.16万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9900395
• 关键词: 10 year old; Accounting; Address; Adolescent; Affect; Age; Agreement; Alcohol or Other Drugs use; Area; Biological; Birth; Brain; Brain Mapping; Child; Child Development; Child Health; Childhood; Cognitive; Cohort Studies; Collaborations; Collection; Communities; Complex; Consultations; Data; Data Collection; Databases; Development; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Ethical Issues; Ethics; Evaluation; Exposure to; Family; Foundations; Fright; Future; Genetic; Goals; Guidelines; Health; Health Promotion; Home environment; Human; Infant; Intervention; Investigation; Knowledge; Laws; Legal; Life; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Methodology; Modeling; Mothers; Near-Infrared Spectroscopy; Neuraxis; Neurocognitive; Opioid; Outcome; Participant; Personal Satisfaction; Phase; Phase II Clinical Trials; Pilot Projects; Policies; Postpartum Women; Poverty; Pregnancy; Pregnant Women; Protocols documentation; Research; Resources; Risk; Risk Factors; Safety; Sampling; Sedation procedure; Social Interaction; Specimen; Standardization; Structure; Substance Use Disorder; Surveys; Target Populations; Techniques; Testing; Time; Vulnerable Populations; Woman; Work; addiction; adverse childhood events; brain behavior; cognitive ability; cognitive development; cognitive performance; cognitive testing; cohort; critical period; design; early childhood; early life exposure; experience; fetal; flexibility; multidisciplinary; multimodality; myelination; neurodevelopment; neuroimaging; opioid exposure; opioid use; opioid use in pregnancy; peer support; phase 2 study; postnatal period; prenatal; prenatal exposure; protocol development; public health relevance; recruit; resilience; retention rate; social; social stigma

PROMOTING RESILIENCE IN CHILDREN: PROTOCOL DEVELOPMENT FOR A BIRTH COHORT STUDY TO ASSESS FACTORS IMPACTING NEURODEVELOPMENT ABSTRACT The first ten years of life are accompanied by rapid changes to the developing brain and cognitive abilities. A multitude of complex interacting factors including genetics, early-life exposure to substances, family and social interactions, and home and community environments can affect the trajectories of brain and cognitive development. Adequate investigations of these effects and interactions have been limited by several factors, including challenges associated with the recruitment and retention of pregnant women with prenatal substance use; the legal, ethical and regulatory issues associated with studies of substance-using pregnant women and children; and the difficulties of performing neuroimaging in infants and young children without sedation. These three linked and synergistic projects aim to address these challenges by developing effective research protocols to lay a foundation for a successful future large-scale, national HEALthy Brain and Cognitive Development (HBCD) birth cohort study, which will follow the developmental trajectories for a decade. Project 1 will develop protocols for recruitment and retention of a diverse sample of pregnant and postpartum women with oversampling of mothers with prenatal opioid use. Project 2 will identify ethical, legal and regulatory challenges for investigations in this vulnerable population, and subsequently define effective solutions to enable recruitment and study of these participants. Project 3 will develop and evaluate protocols for acquiring high-quality, quantitative neuroimaging measures with magnetic resonance imaging and functional near infrared spectroscopy, as well as assess effective strategies for measuring cognitive performance in young children, including those exposed to opioids. These linked projects are essential to address the major challenges with the planned HBCD study and will leverage a highly collaborative, multidisciplinary team; leading-edge neuroimaging techniques; and outstanding institutional resources.

促进儿童的韧性：生育队列研究的协议开发 评估影响神经发育的因素 抽象的 生命的前十年伴随着发展的大脑和认知能力的快速变化。一个 多种复杂的相互作用因素，包括遗传学，早期对物质，家庭和社会的暴露 互动以及家庭和社区环境会影响大脑和认知的轨迹 发展。对这些影响和相互作用的充分研究受到了几个因素的限制， 包括与产前物质招募和保留孕妇有关的挑战 使用;与使用物质孕妇研究有关的法律，道德和法规问题以及 孩子们;以及在没有镇静的婴儿和幼儿进行神经影像的困难。这些 三个链接和协同的项目旨在通过开发有效的研究来应对这些挑战 为成功的未来大规模，国家健康的大脑和认知奠定基础的协议 发展（HBCD）出生队列研究，该研究将遵循十年的发展轨迹。项目 1将制定招募和保留多种孕妇和产后妇女样本的方案 用产前阿片类药物使用的母亲过度采样。项目2将确定道德，法律和法规 在这个脆弱人群中调查的挑战，随后定义了有效的解决方案 可以招募和研究这些参与者。项目3将制定和评估获取协议 具有磁共振成像的高质量，定量神经影像措施，在附近功能 红外光谱以及评估衡量年轻认知表现的有效策略 儿童，包括接触阿片类药物的孩子。这些链接的项目对于解决专业至关重要 计划中的HBCD研究挑战，并将利用高度协作的多学科团队； 领先的神经影像技术；和出色的机构资源。