Psychological and inflammatory biobehavioral mechanisms underlying the association between bereavement and cardiovascular disease

丧亲之痛与心血管疾病之间关联的心理和炎症生物行为机制

基本信息

批准号：
10152696
负责人：
Anoushka D. Shahane
金额：
$ 1.55万
依托单位：
RICE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-17 至 2021-12-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10152696
关键词：
18 year old Accounting Address Adult Age Back Bereavement Biological Biological Assay Biological Markers Blood C-reactive protein Cardiovascular Diseases Cessation of life Climacteric Clinical Dependence Development Emotional Emotions Equation Exhibits Funding Future Gender Goals Grief reaction Guilt Health Heart Heart Diseases Hematological Disease Immunologic Factors Individual Inflammation Inflammatory Inflammatory Response Interleukin-10 Interleukin-6 Intervention Interview Knowledge Language Lesion Letters Light Linguistics Link Longevity Lung Mediating Mental Depression Mental Health Methods Mission Modeling Morbidity - disease rate National Heart, Lung, and Blood Institute Negative Valence Oral Outcome Participant Persons Phase Physical activity Physiological Population Procedures Psychological Factors Psychoneuroimmunology Psychotherapy Public Health Questionnaires Reaction Research Design Risk Role Serum Sleeplessness Spouses Standardization Stimulus Stress Structure TNF gene Training Transcript Vulnerable Populations Work anakinra biobehavior blood treatment cardiovascular disorder risk cardiovascular risk factor clinically relevant clinically significant coping cytokine depressive symptoms design disorder prevention effective therapy emotion regulation emotional reaction experience immune function improved indexing lexical mortality mortality risk natural language novel perceived stress physical conditioning psychologic resilience response skills sleep quality stressor thrombotic complications

项目摘要

Project Summary The loss of a spouse is one of most stressful experiences one can encounter. In the face of such loss, people are physiologically and emotionally dysregulated. As a result, bereaved individuals are at increased risk of cardiovascular disease (CVD), morbidity, and mortality. CVD accounts for an astounding 20-53% of deaths following loss of a spouse. Highly stressed individuals, such as bereaved spouses, exhibit heightened inflammatory responses in comparison to those who are less stressed. Importantly, inflammation is a predictor of all stages of CVD from initial lesion to end-stage thrombotic complications. Therefore, as bereaved individuals are highly stressed and at increased risk of CVD, inflammation may be a key mechanism underlying this CVD risk. Further, bereavement-related stress is often manifested in emotional and physical reactions such as despair, symptoms of depression, excessive grief rumination, insomnia, and decreased physical activity. In bereavement, the ability to successfully regulate emotion is a vital skill for healthy coping, predictive of health outcomes, and may represent a key psychological mechanism accounting for varying degrees of resilience. Psychological distancing is one promising adaptive emotion regulation strategy in which an individual appraises a negative situation by taking a step back, distancing oneself, and coolly, objectively evaluates what is happening. The objective of the present work is to investigate if psychological distancing, implemented implicitly via natural language use (i.e., linguistic distancing (LD)), is related to proinflammatory cytokine biomarkers of CVD risk and bereavement-related health indicators. 160 participants who experienced the loss of their spouse within the last two months will complete questionnaires that index bereavement-related health indices (i.e., risk for mortality, general health, symptoms of depression, perceived stress, grief rumination, sleep quality, and physical activity), and undergo a blood draw to assess proinflammatory cytokine biomarkers of CVD risk. Participants will be asked to discuss their relationship with the deceased spouse for six minutes while being recorded. To assess LD, lexical assays of each participant's oral transcripts will index the extent of his or her spontaneous psychological distancing using a well-established, standardized LD metric. Greater LD scores indicate greater psychological distancing and have been associated with more adaptive emotion regulation and health indices. Primary aims include assessing (1) if LD is negatively associated with CVD- related proinflammatory cytokine responses, (2) if LD is negatively related to deleterious bereavement-related health indicators, and (3) as an exploratory aim, examining and characterizing functional interrelationships among LD, proinflammatory cytokine responses, and bereavement-related health indices. This work may explain novel dependencies among language, emotion, and CVD risk, identify resilience factors, and probe the translational value of LD in this vulnerable population to inform the future design of scalable, effective treatments to reduce risk of CVD, morbidity, and mortality.

项目概要失去配偶是一个人可能遇到的最有压力的经历之一。面对这样的损失，人们生理和情绪失调。因此，失去亲人的人面临更大的风险心血管疾病（CVD）、发病率和死亡率。 CVD 占死亡人数的 20-53%，令人震惊失去配偶后。压力大的人，例如失去亲人的配偶，表现出更高的与压力较小的人相比，炎症反应更明显。重要的是，炎症是一个预测因素 CVD 的所有阶段，从初始病变到终末期血栓并发症。因此，作为死者个体压力很大，心血管疾病风险增加，炎症可能是潜在的关键机制这种CVD风险。此外，与丧亲之痛相关的压力通常表现为情绪和身体反应，例如如绝望、抑郁症状、过度悲伤沉思、失眠和体力活动减少。在丧亲之痛，成功调节情绪的能力是健康应对、预测健康的重要技能结果，并且可能代表了解释不同程度的弹性的关键心理机制。心理疏远是一种有前途的适应性情绪调节策略，其中个体通过后退一步、保持距离、冷静、客观地评估负面情况来评价负面情况正在发生。目前工作的目的是调查是否实施了心理疏远通过自然语言使用（即语言距离（LD））隐式地与促炎细胞因子相关 CVD 风险的生物标志物和与丧亲之痛相关的健康指标。 160 名经历过损失的参与者他们的配偶在过去两个月内将完成调查问卷，以反映与丧亲之痛相关的健康状况指数（即死亡风险、总体健康状况、抑郁症状、感知压力、悲伤沉思、睡眠质量和身体活动），并进行抽血以评估促炎细胞因子生物标志物 CVD 风险。参与者将被要求讨论他们与已故配偶的关系六分钟正在录音时。为了评估 LD，对每个参与者的口头记录的词汇分析将索引他或她使用完善的标准化 LD 指标自发地进行心理疏远。更大的LD 分数表明更大的心理距离，并与更具适应性的情绪相关监管和健康指数。主要目标包括评估 (1) LD 是否与 CVD 呈负相关。相关的促炎细胞因子反应，(2) 如果 LD 与有害的丧亲相关呈负相关健康指标，以及（3）作为探索性目标，检查和表征功能相互关系 LD、促炎细胞因子反应和丧亲相关的健康指数。这项工作可能解释语言、情绪和心血管疾病风险之间的新依赖性，识别弹性因素，并探讨 LD 在这一弱势群体中的转化价值，可为未来可扩展、有效的设计提供信息降低 CVD 风险、发病率和死亡率的治疗方法。